Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P₁ modulator ponesimod

Alexander Treibera Department of Non-Clinical Drug Metabolism and Pharmacokinetics (AT, SS, JS), Idorsia Pharmaceuticals Ltd, Allschwil, SwitzerlandCorrespondence[email protected]
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Swen Seelanda Department of Non-Clinical Drug Metabolism and Pharmacokinetics (AT, SS, JS), Idorsia Pharmaceuticals Ltd, Allschwil, SwitzerlandView further author information

Jérôme Segrestaaa Department of Non-Clinical Drug Metabolism and Pharmacokinetics (AT, SS, JS), Idorsia Pharmaceuticals Ltd, Allschwil, SwitzerlandView further author information

Cyrille Lescopb Drug Discovery Chemistry (CL, MHB), Idorsia Pharmaceuticals Ltd, Allschwil, SwitzerlandView further author information

Martin H. Bollib Drug Discovery Chemistry (CL, MHB), Idorsia Pharmaceuticals Ltd, Allschwil, SwitzerlandView further author information

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Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P₁ modulator ponesimod

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Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P1 modulator ponesimod

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Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P₁ modulator ponesimod