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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 11
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Research Article

Induction of CYP3A isoforms in cultured precisioncut human liver slices

B. G. LAKE BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
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S. E. BALL BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
,
A. B. RENWICK BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
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J. M. TREDGER BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
,
J. KAO BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
,
J. A. BEAMAND BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
&
R. J. PRICE BIBRA International,Woodmansterne Road, Carshalton SM5 4DS, UK OE Wyeth-Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543- 8000, USA Institute of Liver Studies, King’s College of Medicine and Dentistry, London SE5 9PJ, UK
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Pages 1165-1173 | Published online: 22 Sep 2008

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Saeed Alqahtani, Loqman A Mohamed & Amal Kaddoumi. (2013) Experimental models for predicting drug absorption and metabolism. Expert Opinion on Drug Metabolism & Toxicology 9:10, pages 1241-1254.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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Rolf Gebhardt, Jan G. Hengstler, Dieter Müller, Reinhild Glöckner, Peter Buenning, Britta Laube, Eva Schmelzer, Martina Ullrich, Dietmar Utesch, Nicola Hewitt, Michael Ringel, Beate Reder Hilz, Augustinus Bader, Angelika Langsch, Thomas Koose, Hans-Jörg Burger, Jochen Maas & Franz Oesch. (2003) New Hepatocyte In Vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures. Drug Metabolism Reviews 35:2-3, pages 145-213.
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B. G. Lake, S. E. Ball, J. Kao, A. B. Renwick, R. J. Price & J. A. Scatina. (2002) Metabolism of zaleplon by human liver: evidence for involvement of aldehyde oxidase. Xenobiotica 32:10, pages 835-847.
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O. Pelkonen, P. Myllynen, P. Taavitsainen, A. R. Boobis, P. Watts, B. G. Lake, R. J. Price, A. B. Renwick, M.-J. Gómez-Lechón, J. V. Castell, M. Ingelman-Sundberg, M. Hidestrand, A. Guillouzo, L. Corcos, P. S. Goldfarb & D. F. V. Lewis. (2001) Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems. Xenobiotica 31:6, pages 321-343.
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Alexander V. LyubimovCostas Ioannides & Brian G. Lake. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Jason R. Catania, Barbara P. McGarrigle, Kate Rittenhouse-Olson & James R. Olson. (2007) Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium. Toxicology in Vitro 21:1, pages 109-115.
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Xiaoming Cui, Ann Thomas, Yi Han, Jairam Palamanda, Diana Montgomery, Ronald E. White, Richard A. Morrison & K.-C. Cheng. (2005) Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: Correlation study with induction in vivo. Journal of Pharmacological and Toxicological Methods 52:2, pages 234-243.
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Oladipo Kukoyi, Tami R. Argo & Ryan M. Carnahan. (2005) Exacerbation of Panic Disorder with Rifampin Therapy in a Patient Receiving Citalopram. Pharmacotherapy 25:3, pages 435-437.
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Graham Somers, Peter Mutch & Amanda Woodrooffe. 2004. A Handbook of Bioanalysis and Drug Metabolism. A Handbook of Bioanalysis and Drug Metabolism.
Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, R. Scott Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh & Steven A. Wrighton. (2003) THE CONDUCT OF IN VITRO AND IN VIVO DRUG-DRUG INTERACTION STUDIES: A PHARMACEUTICAL RESEARCH AND MANUFACTURERS OF AMERICA (PhRMA) PERSPECTIVE. Drug Metabolism and Disposition 31:7, pages 815-832.
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Esther F.A Brandon, Christiaan D Raap, Irma Meijerman, Jos H Beijnen & Jan H.M Schellens. (2003) An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicology and Applied Pharmacology 189:3, pages 233-246.
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Thorir D. Bjornsson, John T. Callaghan, Heidi J. Einolf, Volker Fischer, Lawrence Gan, Scott Grimm, John Kao, S. Peter King, Gerald Miwa, Lan Ni, Gondi Kumar, James McLeod, Scott R. Obach, Stanley Roberts, Amy Roe, Anita Shah, Fred Snikeris, John T. Sullivan, Donald Tweedie, Jose M. Vega, John Walsh & Steven A. Wrighton. (2003) The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective. The Journal of Clinical Pharmacology 43:5, pages 443-469.
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Robert J. Edwards, Roger J. Price, Patricia S. Watts, Anthony B. Renwick, J. Michael Tredger, Alan R. Boobis & Brian G. Lake. (2003) Induction of Cytochrome P450 Enzymes in Cultured Precision-Cut Human Liver Slices. Drug Metabolism and Disposition 31:3, pages 282-288.
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Reinhild Glöckner, Juliane Wagener, Angelika Lieder & Dieter Müller. (2003) In vitro induction of cytochrome P4503A1-mRNA and testosterone hydroxylation in precision-cut liver slices from male and female rats. Experimental and Toxicologic Pathology 54:5-6, pages 411-415.
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David C. Evans, Dylan P. Hartley & Raymond Evers. 2003. 315 331 .
Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans & Jan van Eijkeren. (2002) Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency. Drug Metabolism and Disposition 30:3, pages 307-313.
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B.G Lake, A.J Edwards, R.J Price, B.J Phillips, A.B Renwick, J.A Beamand & T.B Adams. (2001) Lack of effect of furfural on unscheduled DNA synthesis in the in vivo rat and mouse hepatocyte DNA repair assays and in precision-cut human liver slices. Food and Chemical Toxicology 39:10, pages 999-1011.
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A Lupp, M Danz & D Müller. (2001) Morphology and cytochrome P450 isoforms expression in precision-cut rat liver slices. Toxicology 161:1-2, pages 53-66.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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John S. Markowitz & C. Lindsay DeVane. (2000) Rifampin-Induced Selective Serotonin Reuptake Inhibitor Withdrawal Syndrome in a Patient Treated With Sertraline. Journal of Clinical Psychopharmacology 20:1, pages 109-110.
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K Walton, R Walker, J.J.M van de Sandt, J.V Castell, A.G.A.A Knapp, G Kozianowski, M Roberfroid & B Schilter. (1999) The application of in vitro data in the derivation of the Acceptable Daily Intake of food additives. Food and Chemical Toxicology 37:12, pages 1175-1197.
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R Glöckner, P Steinmetzer, C Drobner & D Müller. (1999) Use of Fresh and Cryopreserved Human Liver Slices in Toxicology with Special Reference to In vitro Induction of Cytochrome P450. Toxicology in Vitro 13:4-5, pages 531-535.
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He Zhang, Edward LeCulyse, Lan Liu, Maowen Hu, Lynn Matoney, Weizhu Zhu & Bingfang Yan. (1999) Rat Pregnane X Receptor: Molecular Cloning, Tissue Distribution, and Xenobiotic Regulation. Archives of Biochemistry and Biophysics 368:1, pages 14-22.
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Sandra CoeckeVera RogiersMartin BaylissJosé CastellJohannes DoehmerGérard FabreJeffrey FryArmin Kern & Carl Westmoreland. (2019) The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status. Alternatives to Laboratory Animals 27:4, pages 579-638.
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Adam T. Drahushuk, Barbara P. McGarrigle, Brian P. Slezak, John J. Stegeman & James R. Olson. (1999) Time- and Concentration-Dependent Induction of CYP1A1 and CYP1A2 in Precision-Cut Rat Liver Slices Incubated in Dynamic Organ Culture in the Presence of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Toxicology and Applied Pharmacology 155:2, pages 127-138.
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Peter Stärkel, Christine Sempoux, Véronique Van Den Berge, Martine Stevens, Christine De Saeger, Jean Pierre Desager & Yves Horsmans. (1999) CYP 3A proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin. Life Sciences 64:8, pages 643-653.
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G. Neupert, R. Glöckner & D. Müller. (1998) Immunohistochemical localization of cytochrome P450 1A1 in precision-cut rat liver slices after in vitro exposure to β-naphthoflavone. Experimental and Toxicologic Pathology 50:4-6, pages 514-518.
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D. Müller, R. Glöckner, M. Rost & P. Steinmetzer. (1998) Monooxygenation, cytochrome P450-mRNA expression and other functions in precision-cut rat liver slices. Experimental and Toxicologic Pathology 50:4-6, pages 507-513.
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