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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 11
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Research Article

NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat

A. W. NICHOLLS Department of Chemistry, Birkbeck College, 29 Gordon Square, London WC1H 0PP, UK OE School of Molecular and Pharm aceutical Science, University of Sussex, Falmer BN1, UK Physical Sciences Research Unit, GlaxoWellcomeMedicines Research Centre, Stevenage SG1 2NY, UK . Department of Safety of Medicines, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK
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J. C. LINDON Department of Chemistry, Birkbeck College, 29 Gordon Square, London WC1H 0PP, UK OE School of Molecular and Pharm aceutical Science, University of Sussex, Falmer BN1, UK Physical Sciences Research Unit, GlaxoWellcomeMedicines Research Centre, Stevenage SG1 2NY, UK . Department of Safety of Medicines, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK
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S. CADDICK Department of Chemistry, Birkbeck College, 29 Gordon Square, London WC1H 0PP, UK OE School of Molecular and Pharm aceutical Science, University of Sussex, Falmer BN1, UK Physical Sciences Research Unit, GlaxoWellcomeMedicines Research Centre, Stevenage SG1 2NY, UK . Department of Safety of Medicines, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK
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R. D. FARRANT Department of Chemistry, Birkbeck College, 29 Gordon Square, London WC1H 0PP, UK OE School of Molecular and Pharm aceutical Science, University of Sussex, Falmer BN1, UK Physical Sciences Research Unit, GlaxoWellcomeMedicines Research Centre, Stevenage SG1 2NY, UK . Department of Safety of Medicines, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK
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I. D. WILSON Department of Chemistry, Birkbeck College, 29 Gordon Square, London WC1H 0PP, UK OE School of Molecular and Pharm aceutical Science, University of Sussex, Falmer BN1, UK Physical Sciences Research Unit, GlaxoWellcomeMedicines Research Centre, Stevenage SG1 2NY, UK . Department of Safety of Medicines, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK
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J. K. NICHOLSON Department of Chemistry, Birkbeck College, 29 Gordon Square, London WC1H 0PP, UK OE School of Molecular and Pharm aceutical Science, University of Sussex, Falmer BN1, UK Physical Sciences Research Unit, GlaxoWellcomeMedicines Research Centre, Stevenage SG1 2NY, UK . Department of Safety of Medicines, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK
Pages 1175-1186 | Published online: 22 Sep 2008

Citations (14)

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Read on this site (3)

A. W. Nicholls, I. D. Wilson, M. Godejohann, J. K. Nicholson & J. P. Shockcor. (2006) Identification of phenacetin metabolites in human urine after administration of phenacetin-C2H3: Measurement of futile metabolic deacetylation via HPLC/MS-SPE-NMR and HPLC-ToF MS. Xenobiotica 36:7, pages 615-629.
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G. B. Scarfe, J. K. Nicholson, J. C. Lindon, I. D. Wilson, S. Taylor, E. Clayton & B. Wright. (2002) Identification of the urinary metabolites of 4-bromoaniline and 4-bromo- [carbonyl - 13 C]-acetanilide in rat. Xenobiotica 32:4, pages 325-337.
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G. B. Scarfe, J. C. Lindon, J. K. Nicholson, P. Martin, B. Wright, S. Taylor, E. Lenz & I. D. Wilson. (2000) Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS. Xenobiotica 30:7, pages 717-729.
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Articles from other publishers (11)

Dandan Wei, Shanting Liao, Junsong Wang, Minghua Yang & Lingyi Kong. (2015) Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling. RSC Advances 5:81, pages 66200-66211.
Crossref
Alexander V. LyubimovScott R. Obach, Deepak K. Dalvie & Gregory S. Walker. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 55 .
Bernard Testa & Stefanie D. Krämer. (2007) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 4:9, pages 2031-2122.
Crossref
A.O. Lawal .A. Ologundudu .F.O. Obi .I.V. Ogungbe .A.O. Olakanye .A.R. Agbetuyi .O.F. Kayode .T. Medale .. (2005) Antioxidant Effects of Aqueous Extract of Sweet Potato and Ascorbic Acid on Paracetamol Induced Damage. Journal of Medical Sciences 6:1, pages 87-92.
Crossref
M Tugnait, E.M Lenz, P Phillips, M Hofmann, M Spraul, J.C Lindon, J.K Nicholson & I.D Wilson. (2002) The metabolism of 4-trifluoromethoxyaniline and [13C]-4-trifluoromethoxyacetanilide in the rat: detection and identification of metabolites excreted in the urine by NMR and HPLC-NMR. Journal of Pharmaceutical and Biomedical Analysis 28:5, pages 875-885.
Crossref
Norbert Staimer, Shirley J Gee & Bruce D Hammock. (2001) Development of a class-selective enzyme immunoassay for urinary phenolic glucuronides. Analytica Chimica Acta 444:1, pages 27-36.
Crossref
Roger M. Smith, Orapin Chienthavorn, Ian D. Wilson, Brian Wright & Stephen D. Taylor. (1999) Superheated Heavy Water as the Eluent for HPLC-NMR and HPLC-NMR-MS of Model Drugs. Analytical Chemistry 71:20, pages 4493-4497.
Crossref
Andrew W Nicholls, John C Lindon, R.Duncan Farrant, John P Shockcor, Ian D Wilson & Jeremy K Nicholson. (1999) Directly-coupled HPLC-NMR spectroscopic studies of metabolism and futile deacetylation of phenacetin in the rat. Journal of Pharmaceutical and Biomedical Analysis 20:6, pages 865-873.
Crossref
U. Holzgrabe. 1999. NMR Spectroscopy in Drug Development and Analysis. NMR Spectroscopy in Drug Development and Analysis 119 134 .
I Wilson, J Nicholson & J Lindon. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 523 550 .
John C. Lindon, Jeremy K. Nicholson & Jeremy R. Everett. 1999. Annual Reports on NMR Spectroscopy Volume 38. Annual Reports on NMR Spectroscopy Volume 38 1 88 .

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