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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 11
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Research Article

Metabolic disposition of [14C]-trimethylamine N-oxide in rat: variation with dose and route of administration

S. C. MITCHELL Pharmacology and Toxicology, Imperial College School of Medicine at St Mary’s, Norfolk Place, London W2 1PG, UK
,
A. Q. ZHANG Pharmacology and Toxicology, Imperial College School of Medicine at St Mary’s, Norfolk Place, London W2 1PG, UK
,
J. M. D. NOBLET Pharmacology and Toxicology, Imperial College School of Medicine at St Mary’s, Norfolk Place, London W2 1PG, UK
,
S. GILLESPIE Pharmacology and Toxicology, Imperial College School of Medicine at St Mary’s, Norfolk Place, London W2 1PG, UK
,
N. JONES Pharmacology and Toxicology, Imperial College School of Medicine at St Mary’s, Norfolk Place, London W2 1PG, UK
&
R. L. SMITH Pharmacology and Toxicology, Imperial College School of Medicine at St Mary’s, Norfolk Place, London W2 1PG, UK
Pages 1187-1197 | Published online: 22 Sep 2008

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Shiva Kalantari & Mohsen Nafar. (2019) An Update of Urine and Blood Metabolomics in Chronic Kidney Disease. Biomarkers in Medicine 13:7, pages 577-596.
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Klaudia M. Maksymiuk, Mateusz Szudzik, Emilia Samborowska, Dawid Chabowski, Marek Konop & Marcin Ufnal. (2024) Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases. PLOS ONE 19:1, pages e0297474.
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Yongning Gao, Jingyu Zhang, Hui Chen, Zhu Wang, Jingjing Hou & Lihua Wang. (2021) Dimethylamine enhances platelet hyperactivity in chronic kidney disease model. Journal of Bioenergetics and Biomembranes 53:5, pages 585-595.
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Hiroyuki Takashima, Takashi Maruyama & Masanori Abe. (2021) Significance of Levocarnitine Treatment in Dialysis Patients. Nutrients 13:4, pages 1219.
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Dimitrios Tsikas. (2020) Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond. Journal of Clinical Medicine 9:6, pages 1843.
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Carlee I. Oakley, Julian A. Vallejo, Derek Wang, Mark A. Gray, LeAnn M. Tiede-Lewis, Tilitha Shawgo, Emmanuel Daon, George Zorn3rd3rd, Jason R. Stubbs & Michael J. Wacker. (2020) Trimethylamine- N -oxide acutely increases cardiac muscle contractility . American Journal of Physiology-Heart and Circulatory Physiology 318:5, pages H1272-H1282.
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Wendy A. Teft, Bridget L. Morse, Brenda F. Leake, Aze Wilson, Sara E. Mansell, Robert A. Hegele, Richard H. Ho & Richard B. Kim. (2016) Identification and Characterization of Trimethylamine- N -oxide Uptake and Efflux Transporters . Molecular Pharmaceutics 14:1, pages 310-318.
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Takashi Maruyama, Terumi Higuchi, Toshio Yamazaki, Erina Okawa, Hideyuki Ando, Osamu Oikawa, Atsushi Inoshita, Kazuyoshi Okada & Masanori Abe. (2017) Levocarnitine Injections Decrease the Need for Erythropoiesis-Stimulating Agents in Hemodialysis Patients with Renal Anemia. Cardiorenal Medicine 7:3, pages 188-197.
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Aki Mafune, Takeo Iwamoto, Yusuke Tsutsumi, Akio Nakashima, Izumi Yamamoto, Keitaro Yokoyama, Takashi Yokoo & Mitsuyoshi Urashima. (2015) Associations among serum trimethylamine-N-oxide (TMAO) levels, kidney function and infarcted coronary artery number in patients undergoing cardiovascular surgery: a cross-sectional study. Clinical and Experimental Nephrology 20:5, pages 731-739.
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Jason R. Stubbs, John A. House, A. Jacob Ocque, Shiqin Zhang, Cassandra Johnson, Cassandra Kimber, Kyle Schmidt, Aditi Gupta, James B. Wetmore, Thomas D. Nolin, John A. Spertus & Alan S. Yu. (2016) Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden. Journal of the American Society of Nephrology 27:1, pages 305-313.
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Ioannis Drosos, Anna Tavridou & George Kolios. (2015) New Aspects on the Metabolic role of Intestinal Microbiota in the Development of Atherosclerosis. Metabolism 64:4, pages 476-481.
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Joseph Loscalzo. (2013) Gut Microbiota, the Genome, and Diet in Atherogenesis. New England Journal of Medicine 368:17, pages 1647-1649.
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Suresh K. Balani, Lisa J. Christopher & Donglu Zhang. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 291 298 .
Xiaohong Sun, Lili Niu, Xiaoqin Li, Xiumei Lu & Famei Li. (2009) Characterization of metabolic profile of mosapride citrate in rat and identification of two new metabolites: Mosapride N-oxide and morpholine ring-opened mosapride by UPLC–ESI-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 50:1, pages 27-34.
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Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbraith, Donald P. Reitberg, Kan He, Anthony BarrosJr.Jr., Anne Blackwood-Chirchir, W. Griffith Humphreys & Ramaswamy A. Iyer. (2008) Metabolism and Disposition of Dasatinib after Oral Administration to Humans. Drug Metabolism and Disposition 36:7, pages 1357-1364.
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Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony BarrosJr.Jr., Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A. Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys & Ramaswamy A. Iyer. (2008) Biotransformation of [ 14 C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys . Drug Metabolism and Disposition 36:7, pages 1341-1356.
Crossref
S.C. Mitchell, A.Q. Zhang & R.L. Smith. (2008) Dimethylamine and diet. Food and Chemical Toxicology 46:5, pages 1734-1738.
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Stephen C. Mitchell, Mary E. Bollard & AiQin Zhang. (2007) Short-chain aliphatic amines in human urine: a mathematical examination of metabolic interrelationships. Metabolism 56:1, pages 19-23.
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S Kenyon, P.L Carmichael, S Khalaque, S Panchal, R Waring, R Harris, R.L Smith & S.C Mitchell. (2004) The passage of trimethylamine across rat and human skin. Food and Chemical Toxicology 42:10, pages 1619-1628.
Crossref
A.Q Zhang, S.C Mitchell & R.L Smith. (1998) Dimethylamine Formation in the Rat from Various Related Amine Precursors. Food and Chemical Toxicology 36:11, pages 923-927.
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