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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 9
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Research Article

Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam

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Pages 913-922 | Published online: 22 Sep 2008

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David J. Greenblatt, Karthik Venkatakrishnan, Jerold S. Harmatz, Sarah J. Parent & Lisa L. von Moltke. (2010) Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro. Xenobiotica 40:10, pages 713-720.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (20)

Kentaro SakaiKazuyuki SaitoAya TakadaWakako HikijiYosuke KikuchiTatsushige Fukunaga. (2018) Deaths Associated With Brotizolam Poisoning From a Single Drug Overdose. American Journal of Forensic Medicine & Pathology 39:1, pages 82-84.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 173 201 .
Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 387 430 .
Na Le Dang, Tyler B. Hughes, Grover P. Miller & S. Joshua Swamidass. (2017) Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes. Chemical Research in Toxicology 30:4, pages 1046-1059.
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Masahisa Sugihara, Susumu Takeuchi, Masaru Sugita, Kazutaka Higaki, Makoto Kataoka & Shinji Yamashita. (2015) Analysis of Intra- and Intersubject Variability in Oral Drug Absorption in Human Bioequivalence Studies of 113 Generic Products. Molecular Pharmaceutics 12:12, pages 4405-4413.
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David E. Moody. 2012. Handbook of Drug Interactions. Handbook of Drug Interactions 25 116 .
Siamak Cyrus Khojasteh, Saileta Prabhu, Jane R. Kenny, Jason S. Halladay & Anthony Y. H. Lu. (2011) Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. European Journal of Drug Metabolism and Pharmacokinetics 36:1, pages 1-16.
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Justas Dapkunas, Andrius Sazonovas & Pranas Japertas. (2009) Probabilistic Prediction of the Human CYP3A4 and CYP2D6 Metabolism Sites. Chemistry & Biodiversity 6:11, pages 2101-2106.
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Arun K. Tiwari, Renan P. Souza & Daniel J. Müller. (2009) Pharmacogenetics of anxiolytic drugs. Journal of Neural Transmission 116:6, pages 667-677.
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T. Fukasawa, A. Suzuki & K. Otani. (2007) Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. Journal of Clinical Pharmacy and Therapeutics 32:4, pages 333-341.
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Yukihiro Ujiie, Takashi Fukasawa, Norio Yasui-Furukori, Akihito Suzuki, Tomonori Tateishi & Koichi Otani. (2006) Rifampicin Markedly Decreases Plasma Concentration and Hypnotic Effect of Brotizolam. Therapeutic Drug Monitoring 28:3, pages 299-302.
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Takaki Tokairin, Takashi Fukasawa, Norio Yasui-Furukori, Toshiaki Aoshima, Akihito Suzuki, Yoshimasa Inoue, Tomonori Tateishi & Koichi Otani. (2005) Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism. British Journal of Clinical Pharmacology 60:2, pages 172-175.
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T. Osanai, T. Ohkubo, N. Yasui, T. Kondo & S. Kaneko. (2004) Effect of itraconazole on the pharmacokinetics and pharmacodynamics of a single oral dose of brotizolam. British Journal of Clinical Pharmacology 58:5, pages 476-481.
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David E. Moody. 2004. Handbook of Drug Interactions. Handbook of Drug Interactions 3 88 .
M. Teresa Donato & Jos?? V. Castell. (2003) Strategies and Molecular Probes to Investigate the Role of Cytochrome P450 in Drug Metabolism. Clinical Pharmacokinetics 42:2, pages 153-178.
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Yohei Otsuji, Naoyuki Okuyama, Toshiaki Aoshima, Takashi Fukasawa, Kimiyasu Kato, Gisa Gerstenberg, Masatomo Miura, Tadashi Ohkubo, Kazunobu Sugawara & Koichi Otani. (2002) No Effect of Itraconazole on the Single Oral Dose Pharmacokinetics and Pharmacodynamics of Estazolam. Therapeutic Drug Monitoring 24:3, pages 375-378.
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Larry C. Wienkers. (2002) Factors confounding the successful extrapolation of in vitro CYP3A inhibition information to the in vivo condition. European Journal of Pharmaceutical Sciences 15:3, pages 239-242.
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R. Hyland, E. G. H. Roe, B. C. Jones & D. A. Smith. (2008) Identification of the cytochrome P450 enzymes involved in the N ‐demethylation of sildenafil . British Journal of Clinical Pharmacology 51:3, pages 239-248.
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Takayuki ASANOHirotaka KUSHIDAChiharu SADAKANEKazuhisa ISHIHARAYoko WAKUIToshihiko YANAGISAWAMasayuki KIMURAHideo KAMEITakemi YOSHIDA. (2001) Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities.. Biological and Pharmaceutical Bulletin 24:6, pages 678-682.
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Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (2000) Effects of the Antifungal Agents on Oxidative Drug Metabolism. Clinical Pharmacokinetics 38:2, pages 111-180.
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