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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 9
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Research Article

Metabolism of 2,4,5,2′,4′,5′-hexachlorobiphenyl (PCB153) in guinea pig

N. ARIYOSHI Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82, Japan OE Department of Food and Nutrition, Nakamura Gakuen University, Johnan-ku, Fukuoka 814-01, Japan
,
N. KOGA Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82, Japan OE Department of Food and Nutrition, Nakamura Gakuen University, Johnan-ku, Fukuoka 814-01, Japan
,
H. YOSHIMURA Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82, Japan OE Department of Food and Nutrition, Nakamura Gakuen University, Johnan-ku, Fukuoka 814-01, Japan
&
K. OGURI* Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-82, Japan OE Department of Food and Nutrition, Nakamura Gakuen University, Johnan-ku, Fukuoka 814-01, Japan
Pages 973-983 | Published online: 22 Sep 2008

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C. Ohta, K. Haraguchi, Y. Kato & N. Koga. (2005) In vitro metabolism of 2,2′,3,4′,5,5′,6-heptachlorobiphenyl (CB187) by liver microsomes from rats, hamsters and guinea pigs. Xenobiotica 35:4, pages 319-330.
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K. Haraguchi, Y Kato, N Koga & M Degawa. (2005) Species differences in the tissue distribution of catechol and methylsulphonyl metabolites of 2,4,5,2',5'-penta- and 2,3,4,2',3',6'-hexachlorobiphenyls in rats, mice, hamsters and guinea pigs. Xenobiotica 35:1, pages 85-96.
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Articles from other publishers (17)

Amanda J. Bullert, Xueshu Li, Binita Gautam, Hui Wang, Andrea Adamcakova-Dodd, Kai Wang, Peter S. Thorne & Hans-Joachim Lehmler. (2024) Distribution of 2,2′,5,5′-Tetrachlorobiphenyl (PCB52) Metabolites in Adolescent Rats after Acute Nose-Only Inhalation Exposure. Environmental Science & Technology 58:14, pages 6105-6116.
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Chun-Yun Zhang, Xueshu Li, Susanne Flor, Patricia Ruiz, Anneli Kruve, Gabriele Ludewig & Hans-Joachim Lehmler. (2022) Metabolism of 3-Chlorobiphenyl (PCB 2) in a Human-Relevant Cell Line: Evidence of Dechlorinated Metabolites. Environmental Science & Technology 56:17, pages 12460-12472.
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Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Gabriele Ludewig & Hans-Joachim Lehmler. (2021) Characterization of the Metabolic Pathways of 4-Chlorobiphenyl (PCB3) in HepG2 Cells Using the Metabolite Profiles of Its Hydroxylated Metabolites. Environmental Science & Technology 55:13, pages 9052-9062.
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Xueshu Li, Yanna Liu, Jonathan W. Martin, Julia Yue Cui & Hans-Joachim Lehmler. (2021) Nontarget analysis reveals gut microbiome-dependent differences in the fecal PCB metabolite profiles of germ-free and conventional mice. Environmental Pollution 268, pages 115726.
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Chun-Yun Zhang, Susanne Flor, Patricia Ruiz, Ram Dhakal, Xin Hu, Lynn M. Teesch, Gabriele Ludewig & Hans-Joachim Lehmler. (2020) 3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells. Environmental Science & Technology 54:19, pages 12345-12357.
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Chiho Ohta, Koichi Haraguchi, Yoshihisa Kato, Tetsuya Endo, Osamu Kimura & Nobuyuki Koga. (2015) Distribution and excretion of 2,2′,3,4′,5,5′,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs. Chemosphere 118, pages 5-11.
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Gabriele Ludewig & Larry W. Robertson. (2013) Polychlorinated biphenyls (PCBs) as initiating agents in hepatocellular carcinoma. Cancer Letters 334:1, pages 46-55.
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Piotr Bernatowicz & Joanna Pijanowska. (2011) Daphnia response to biotic stress is modified by PCBs. Ecotoxicology and Environmental Safety 74:4, pages 711-718.
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A. Baumann, W. Lohmann, T. Rose, K. C. Ahn, B. D. Hammock, U. Karst & N. H. Schebb. (2010) Electrochemistry-Mass Spectrometry Unveils the Formation of Reactive Triclocarban Metabolites. Drug Metabolism and Disposition 38:12, pages 2130-2138.
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Jonathan Verreault, Robert J. Letcher, Christian Sonne & Rune Dietz. (2009) In vitro metabolism of polychlorinated biphenyls and cytochrome P450 monooxygenase activities in dietary-exposed Greenland sledge dogs. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 150:1, pages 91-100.
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Koichi Haraguchi, Nobuyuki Koga & Yoshihisa Kato. (2005) COMPARATIVE METABOLISM OF POLYCHLORINATED BIPHENYLS AND TISSUE DISTRIBUTION OF PERSISTENT METABOLITES IN RATS, HAMSTERS, AND GUINEA PIGS. Drug Metabolism and Disposition 33:3, pages 373-380.
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Hai Pham‐Tuan, Christina Larsson, Frank Hoffmann, Åke Bergman, Michael Fröba & Heinrich Hühnerfuss. (2005) Enantioselective semipreparative HPLC separation of PCB metabolites and their absolute structure elucidation using electronic and vibrational circular dichroism. Chirality 17:5, pages 266-280.
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Prasada Rao S Kodavanti, Thomas R Ward, Ethel C Derr-Yellin, James D McKinney & Hugh A Tilson. (2003) Increased [3H]Phorbol Ester Binding in Rat Cerebellar Granule Cells and Inhibition of 45Ca2+ Buffering in Rat Cerebellum by Hydroxylated Polychlorinated Biphenyls. NeuroToxicology 24:2, pages 187-198.
Crossref
Anders Ruus, Morten Sandvik, Karl I Ugland & Janneche U Skaare. (2002) Factors influencing activities of biotransformation enzymes, concentrations and compositional patterns of organochlorine contaminants in members of a marine food web. Aquatic Toxicology 61:1-2, pages 73-87.
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Alice C. Layton, John Sanseverino, Betsy W. Gregory, James P. Easter, Gary S. Sayler & T.Wayne Schultz. (2002) In Vitro Estrogen Receptor Binding of PCBs: Measured Activity and Detection of Hydroxylated Metabolites in a Recombinant Yeast Assay. Toxicology and Applied Pharmacology 180:3, pages 157-163.
Crossref
Hans-Joachim Lehmler & Larry W. Robertson. (2001) Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling. Chemosphere 45:8, pages 1119-1127.
Crossref
Robert J. Letcher, Eva Klasson-Wehler & Ake Bergman. 2000. Volume 3 Anthropogenic Compounds Part K. Volume 3 Anthropogenic Compounds Part K 315 359 .

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