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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 7
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Research Article

Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A

L. NADELMANN* Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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J. TJORNELUND Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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S. H. HANSEN Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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C. CORNETT Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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U. G. SIDELMANN Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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U. BRAUMANN Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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E. CHRISTENSEN Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
&
S. B. CHRISTENSEN Department of Analytical and Pharmaceutical Chemistry, OE Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100 Copenhagen, Denmark Bruker Analytische Messteknik GmbH, Silberstreifen D-76287, Rheinstetten, Germany . Mullegaard Breeding and Research Centre A} S, Tornbjergvej 40, DK-4623 Lille Skensved, Denmark
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Pages 667-680 | Published online: 22 Sep 2008

Citations (11)

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Lívia Mara Silva, Danielle Gomes Marconato, Marcos Paulo Nascimento da Silva, Nádia Rezende Barbosa Raposo, Gabriela de Faria Silva Facchini, Gilson Costa Macedo, Fernanda de Sá Teixeira, Maria Cecília Barbosa da Silveira Salvadori, Priscila de Faria Pinto, Josué de Moraes, Frederico Pittella & Ademar Alves Da Silva Filho. (2021) Licochalcone A-Loaded Solid Lipid Nanoparticles Improve Antischistosomal Activity In Vitro and In Vivo. Nanomedicine 16:19, pages 1641-1655.
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Yang-Liu Xia, Tong-Yi Dou, Xia Lv & Guang-Bo Ge. (2019) In vitro characterization of the glucuronidation pathways of licochalcone A mediated by human UDP-glucuronosyltransferases. Xenobiotica 49:6, pages 671-677.
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Articles from other publishers (9)

Fubo Han, Yina Xiao & Ik-Soo Lee. (2021) Microbial Conjugation Studies of Licochalcones and Xanthohumol. International Journal of Molecular Sciences 22:13, pages 6893.
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Lingyi Huang, Dejan Nikolic & Richard B. van Breemen. (2017) Hepatic metabolism of licochalcone A, a potential chemopreventive chalcone from licorice (Glycyrrhiza inflata), determined using liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry 409:30, pages 6937-6948.
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Rudi Oliveira, Daniela Miranda, Joana Magalhães, Rita Capela, Maria J. Perry, Paul M. O’Neill, Rui Moreira & Francisca Lopes. (2015) From hybrid compounds to targeted drug delivery in antimalarial therapy. Bioorganic & Medicinal Chemistry 23:16, pages 5120-5130.
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Zvi RappoportPaul M. O'Neill, James Chadwick & Sarah L. Rawe. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Mike Clifford & J Brown. 2005. Flavonoids. Flavonoids 319 370 .
Paul M. O'Neill, Amira Mukhtar, Stephen A. Ward, Jamie F. Bickley, Jill Davies, Mario D. Bachi & Paul A. Stocks. (2004) Application of Thiol−Olefin Co-oxygenation Methodology to a New Synthesis of the 1,2,4-Trioxane Pharmacophore. Organic Letters 6:18, pages 3035-3038.
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Paul M. O'Neill, Paul A. Stocks, Matthew D. Pugh, Nuna C. Araujo, Edward E. Korshin, Jamie F. Bickley, Stephen A. Ward, Patrick G. Bray, Erica Pasini, Jill Davies, Edite Verissimo & Mario D. Bachi. (2004) Design and Synthesis of Endoperoxide Antimalarial Prodrug Models. Angewandte Chemie International Edition 43:32, pages 4193-4197.
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Paul M. O'Neill, Paul A. Stocks, Matthew D. Pugh, Nuna C. Araujo, Edward E. Korshin, Jamie F. Bickley, Stephen A. Ward, Patrick G. Bray, Erica Pasini, Jill Davies, Edite Verissimo & Mario D. Bachi. (2004) Design and Synthesis of Endoperoxide Antimalarial Prodrug Models. Angewandte Chemie 116:32, pages 4289-4293.
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Lynda Nadelmann, Jette Tjørnelund, Egon Christensen & Steen Honoré Hansen. (1997) High-performance liquid chromatographic determination of licochalcone A and its metabolites in biological fluids. Journal of Chromatography B: Biomedical Sciences and Applications 695:2, pages 389-400.
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