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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 7
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Research Article

Irgasan®DP 300 (5-chloro-2-(2,4-dichlorophenoxy)phenol) induces cytochrome P450s and inhibits haembiosynthesis in rat hepatocytes cultured on Matrigel

H. JINNO* Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan OE Faculty of Pharmaceutical Sciences, Science University of Tokyo, 1-3 Kagurazaka, Shinjyuku-ku, Tokyo, 163, Japan
,
N. HANIOKA Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan OE Faculty of Pharmaceutical Sciences, Science University of Tokyo, 1-3 Kagurazaka, Shinjyuku-ku, Tokyo, 163, Japan
,
S. ONODERA Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan OE Faculty of Pharmaceutical Sciences, Science University of Tokyo, 1-3 Kagurazaka, Shinjyuku-ku, Tokyo, 163, Japan
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T. NISHIMURA Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan OE Faculty of Pharmaceutical Sciences, Science University of Tokyo, 1-3 Kagurazaka, Shinjyuku-ku, Tokyo, 163, Japan
&
M. ANDO Division of Environmental Chemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158, Japan OE Faculty of Pharmaceutical Sciences, Science University of Tokyo, 1-3 Kagurazaka, Shinjyuku-ku, Tokyo, 163, Japan
Pages 681-692 | Published online: 22 Sep 2008

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Gwendolyn W. Louis, Daniel R. Hallinger, M. Janay Braxton, Alaa Kamel & Tammy E. Stoker. (2017) Effects of chronic exposure to triclosan on reproductive and thyroid endpoints in the adult Wistar female rat. Journal of Toxicology and Environmental Health, Part A 80:4, pages 236-249.
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Raphael J. Witorsch. (2014) Critical analysis of endocrine disruptive activity of triclosan and its relevance to human exposure through the use of personal care products. Critical Reviews in Toxicology 44:6, pages 535-555.
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Susan S. Schiffman & Kristina I. Rother. (2013) Sucralose, A Synthetic Organochlorine Sweetener: Overview Of Biological Issues. Journal of Toxicology and Environmental Health, Part B 16:7, pages 399-451.
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JIA-LONG Fang, ROBINL. STINGLEY, FREDERICKA. BELAND, WAFA HARROUK, DEBBIEL. LUMPKINS & PAUL HOWARD. (2010) Occurrence, Efficacy, Metabolism, and Toxicity of Triclosan. Journal of Environmental Science and Health, Part C 28:3, pages 147-171.
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Articles from other publishers (15)

L. W. B. Olaniyan, N. Mkwetshana & A. I. Okoh. (2016) Triclosan in water, implications for human and environmental health. SpringerPlus 5:1.
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Mei-Fei YuehRobert H. Tukey. (2016) Triclosan: A Widespread Environmental Toxicant with Many Biological Effects. Annual Review of Pharmacology and Toxicology 56:1, pages 251-272.
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Alba Quesada-García, Ana Valdehita, Iván del Olmo, M. José Gómez & José M. Navas. (2015) Detection of Effects Caused by Very Low Levels of Contaminants in Riverine Sediments Through a Combination of Chemical Analysis, In Vitro Bioassays, and Farmed Fish as Sentinel. Archives of Environmental Contamination and Toxicology 68:4, pages 663-677.
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Katie B. Paul, Joan M. Hedge, Daniel M. Rotroff, Michael W. Hornung, Kevin M. Crofton & Steven O. Simmons. (2014) Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening. Chemical Research in Toxicology 27:3, pages 387-399.
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Katie B. Paul, Jerry T. Thompson, Steven O. Simmons, John P. Vanden Heuvel & Kevin M. Crofton. (2013) Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors. Toxicology in Vitro 27:7, pages 2049-2060.
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Alice Hontela & Hamid R. Habibi. 2013. Organic Chemical Toxicology of Fishes. Organic Chemical Toxicology of Fishes 411 437 .
Andrea B. Dann & Alice Hontela. (2011) Triclosan: environmental exposure, toxicity and mechanisms of action. Journal of Applied Toxicology 31:4, pages 285-311.
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Katie B. Paul, Joan M. Hedge, Michael J. DeVito & Kevin M. Crofton. (2010) Short-term Exposure to Triclosan Decreases Thyroxine In Vivo via Upregulation of Hepatic Catabolism in Young Long-Evans Rats. Toxicological Sciences 113:2, pages 367-379.
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Mats Allmyr, Georgios Panagiotidis, Erik Sparve, Ulf Diczfalusy & Gunilla Sandborgh-Englund. (2009) Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones. Basic & Clinical Pharmacology & Toxicology 105:5, pages 339-344.
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Todd R. MillerJochen HeidlerSteven N. ChillrudAmelia DeLaquilJerry C. RitchieJana N. MihalicRichard BoppRolf U. Halden. (2008) Fate of Triclosan and Evidence for Reductive Dechlorination of Triclocarban in Estuarine Sediments. Environmental Science & Technology 42:12, pages 4570-4576.
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Kevin M. Crofton, Katie B. Paul, Michael J. DeVito & Joan M. Hedge. (2007) Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine. Environmental Toxicology and Pharmacology 24:2, pages 194-197.
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Merete Grung, Rainer Lichtenthaler, Marijan Ahel, Knut-Erik Tollefsen, Katherine Langford & Kevin V. Thomas. (2007) Effects-directed analysis of organic toxicants in wastewater effluent from Zagreb, Croatia. Chemosphere 67:1, pages 108-120.
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Miriam N. Jacobs, Gail T. Nolan & Steven R. Hood. (2005) Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicology and Applied Pharmacology 209:2, pages 123-133.
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Hideto Jinno, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Seiich Ishida, Mayumi Saeki, Akiko Soyama, Masaya Itoda, Tetsuji Nishimura, Yoshiro Saito, Shogo Ozawa, Masanori Ando & Jun-ichi Sawada. (2004) Identification of Novel Alternative Splice Variants of Human Constitutive Androstane Receptor and Characterization of Their Expression in the Liver. Molecular Pharmacology 65:3, pages 496-502.
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H Jinno, N Hatakeyama, N Hanioka, R Yoda, T Nishimura & M Ando. (1999) Cytotoxic and porphyrinogenic effects of diphenyl ethers in cultured rat hepatocytes: chlornitrofen (CNP), CNP-amino, chlomethoxyfen and bifenox. Food and Chemical Toxicology 37:1, pages 69-74.
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