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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 7
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Research Article

Diethanolamine absorption, metabolism and disposition in rat and mouse following oral, intravenous and dermal administration

J. M. MATHEWS* Center for Bioorganic Chemistry, Research Triangle Institute and OE National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
,
C. E. GARNER Center for Bioorganic Chemistry, Research Triangle Institute and OE National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
,
S. L. BLACK Center for Bioorganic Chemistry, Research Triangle Institute and OE National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
&
H. B. MATTHEWS Center for Bioorganic Chemistry, Research Triangle Institute and OE National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Pages 733-746 | Published online: 22 Sep 2008

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Duck Soo Lim, Tae Hyun Roh, Min Kook Kim, Yong Chan Kwon, Seul Min Choi, Seung Jun Kwack, Kyu Bong Kim, Sungpil Yoon, Hyung Sik Kim & Byung-Mu Lee. (2018) Risk assessment of N-nitrosodiethylamine (NDEA) and N-nitrosodiethanolamine (NDELA) in cosmetics. Journal of Toxicology and Environmental Health, Part A 81:12, pages 465-480.
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Hugh A. Barton, Timothy P. Pastoor, Karl Baetcke, Janice E. Chambers, Janet Diliberto, Nancy G. Doerrer, Jeffrey H. Driver, Charles E. Hastings, Seshadri Iyengar, Robert Krieger, Bernhard Stahl & Charles Timchalk. (2006) The Acquisition and Application of Absorption, Distribution, Metabolism, and Excretion (ADME) Data in Agricultural Chemical Safety Assessments. Critical Reviews in Toxicology 36:1, pages 9-35.
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Articles from other publishers (24)

Olubusayo Alofe, Edwina Kisanga, Salmaan H. Inayat-Hussain, Masao Fukumura, Rolando Garcia-Milian, Lalith Perera, Vasilis Vasiliou & Shannon Whirledge. (2019) Determining the endocrine disruption potential of industrial chemicals using an integrative approach: Public databases, in vitro exposure, and modeling receptor interactions. Environment International 131, pages 104969.
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K.A. Shipkowski, J.M. Sanders, J.D. McDonald, C.E. Garner, M. Doyle-Eisele, C.J. Wegerski & S. Waidyanatha. (2019) Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration. Toxicology and Applied Pharmacology 378, pages 114592.
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Nancy B. Hopf, Philipp Spring, Gregory Plateel & Aurelie Berthet. (2019) Ethanolamines permeate slowly across human skin ex vivo, but cause severe skin irritation at low concentrations. Archives of Toxicology 93:9, pages 2555-2564.
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Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. MarksJrJr, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder & F. Alan Andersen. (2017) Safety Assessment of Diethanolamine and Its Salts as Used in Cosmetics. International Journal of Toxicology 36:5_suppl2, pages 89S-110S.
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C.R. Kirman, B. Hughes, R.A. Becker & S.M. Hays. (2016) Derivation of a No-significant-risk-level (NSRL) for dermal exposures to diethanolamine. Regulatory Toxicology and Pharmacology 76, pages 137-151.
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P. Robinan Gentry, Tamara House-Knight, Angela Harris, Tracy Greene & Sharan Campleman. (2013) Potential occupational risk of amines in carbon capture for power generation. International Archives of Occupational and Environmental Health 87:6, pages 591-606.
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Bingxuan Wang, David E. Amacher & Margaret H. Whittaker. (2014) Derivation of a No-Significant-Risk-Level (NSRL) for diethanolamine (DEA). Regulatory Toxicology and Pharmacology 68:1, pages 76-84.
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A.O. Gamer, R. Rossbacher, W. Kaufmann & B. van Ravenzwaay. (2008) The Inhalation toxicity of di- and triethanolamine upon repeated exposure. Food and Chemical Toxicology 46:6, pages 2173-2183.
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W.T. Stott & K.M. Kleinert. (2008) Effect of diisopropanolamine upon choline uptake and phospholipid synthesis in Chinese hamster ovary cells. Food and Chemical Toxicology 46:2, pages 761-766.
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S.A. Saghir, S.W. Frantz, M.W. Spence, R.J. Nolan, E.R. Lowe, D.L. Rick & M.J. Bartels. (2007) Pharmacokinetics and bioavailability of diisopropanolamine (DIPA) in rats following intravenous or dermal application. Food and Chemical Toxicology 45:10, pages 2047-2056.
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K.A. Johnson, M.D. Dryzga, K.J. Brooks, E.W. Carney, B. Tornesi & W.T. Stott. (2007) Repeated dose toxicity and developmental toxicity of diisopropanolamine to rats. Food and Chemical Toxicology 45:10, pages 1838-1845.
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John N. Zvimba & Graham E. Jackson. (2007) Solution equilibria of copper(II) complexation with N,N′-(2,2′-azanediylbis(ethane-2,1-diyl))dipicolinamide: A bio-distribution and dermal absorption study. Journal of Inorganic Biochemistry 101:8, pages 1120-1128.
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Steven H. Zeisel. (2007) Response to: DEA in consumer products is safe. The FASEB Journal 21:1, pages 296-297.
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John Bailey. (2007) DEA in consumer products is safe. The FASEB Journal 21:1, pages 295-295.
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Małgorzata Kupczewska-Dobecka & Sławomir Czerczak. (2006) The Skin Notation in the Mac List and Classification of Dangerous Chemicals. International Journal of Occupational Medicine and Environmental Health 19:2.
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Hon-Wing Leung, Lisa M. Kamendulis & William T. Stott. (2005) Review of the carcinogenic activity of diethanolamine and evidence of choline deficiency as a plausible mode of action. Regulatory Toxicology and Pharmacology 43:3, pages 260-271.
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Lisa M. Kamendulis & James E. Klaunig. (2005) Species Differences in the Induction of Hepatocellular DNA Synthesis by Diethanolamine. Toxicological Sciences 87:2, pages 328-336.
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Catherine J. Price, Melissa C. Marr, Christina B. Myers & Gloria D. Jahnke. (2005) Postnatal development of rat pups after maternal exposure to diethanolamine. Birth Defects Research Part B: Developmental and Reproductive Toxicology 74:3, pages 243-254.
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W. Mellert, W. Kaufmann, R. Rossbacher & B. van Ravenzwaay. (2004) Investigations on cell proliferation in B6C3F 1 mouse liver by diethanolamine. Food and Chemical Toxicology 42:1, pages 127-134.
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Lois D Lehman-McKeeman. (2002) Incorporating mechanistic data into risk assessment. Toxicology 181-182, pages 271-274.
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L. D. Lehman-McKeeman, E. A. Gamsky, S. M. Hicks, J. D. Vassallo, M.-H. Mar & S. H. Zeisel. (2002) Diethanolamine Induces Hepatic Choline Deficiency in Mice. Toxicological Sciences 67:1, pages 38-45.
Crossref
A.L Mendrala, J.M WaechterJr.Jr., G.A Bormett, M.J Bartels & W.T Stott. (2001) The pharmacokinetics of diethanolamine in Sprague–Dawley rats following intravenous administration. Food and Chemical Toxicology 39:9, pages 931-939.
Crossref
W.T Stott, J.M WaechterJrJr, D.L Rick & A.L Mendrala. (2000) Absorption, distribution, metabolism and excretion of intravenously and dermally administered triethanolamine in mice. Food and Chemical Toxicology 38:11, pages 1043-1051.
Crossref
W.T Stott, M.J Bartels, K.A Brzak, M.-H Mar, D.A Markham, C.M Thornton & S.H Zeisel. (2000) Potential mechanisms of tumorigenic action of diethanolamine in mice. Toxicology Letters 114:1-3, pages 67-75.
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