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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 6
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Research Article

The isoflavones equol and genistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells

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Pages 587-596 | Published online: 22 Sep 2008

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Mailin Gan, Dongli Yang, Yuan Fan, Jingjing Du, Linyuan Shen, Qiang Li, Yanzhi Jiang, Guoqing Tang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang & Li Zhu. (2020) Bidirectional regulation of genistein on the proliferation and differentiation of C2C12 myoblasts. Xenobiotica 50:11, pages 1352-1358.
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Isha Taneja, Kanumuri Siva Rama Raju & Muhammad Wahajuddin. (2016) Dietary Isoflavones as Modulators of Drug Metabolizing Enzymes and Transporters: Effect on Prescription Medicines. Critical Reviews in Food Science and Nutrition 56:sup1, pages S95-S109.
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Bruce P Burnett, Lakshmi Pillai, Alessandra Bitto, Francesco Squadrito & Robert M Levy. (2011) Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women. International Journal of Women's Health 3, pages 139-150.
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Anni R. Thomsen, Alicja Mortensen, Vibeke M. Breinholt, Rikke H. Lindecrona, Jose L. Penalvo & Ilona K. Sorensen. (2005) Influence of Prevastein®, an Isoflavone-Rich Soy Product, on Mammary Gland Development and Tumorigenesis in Tg.NK (MMTV/c-neu) Mice. Nutrition and Cancer 52:2, pages 176-188.
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Taro KISHIDA, Manabu NAGAMOTO, Yohhei OHTSU, Miho WATAKABE, Daisuke OHSHIMA, Kunitaka NASHIKI, Takafumi MIZUSHIGE, Tohru IZUMI, Akio OBATA & Kiyoshi EBIHARA. (2004) Lack of an Inducible Effect of Dietary Soy Isoflavones on the mRNA Abundance of Hepatic Cytochrome P-450 Isozymes in Rats. Bioscience, Biotechnology, and Biochemistry 68:3, pages 508-515.
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Franziska Kramer, Pia S. Jensen, Anne M. Vinggaard, Erik H. Larsen & Vibeke M. Breinholt. (2003) Effect of In Utero-Administered Coumestrol, Equol, and Organic Selenium on Biomarkers for Phase 2 Enzyme Capacity and Redox Status. Nutrition and Cancer 46:1, pages 73-81.
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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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Taro Kishida, Mami Beppu, Kunitaka Nashiki, Toru Izumi & Kiyoshi Ebihara. (2000) Effect of Dietary Soy Isoflavone Aglycones on the Urinary 16α-to-2-Hydroxyestrone Ratio in C3H/HeJ Mice. Nutrition and Cancer 38:2, pages 209-214.
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Articles from other publishers (27)

Tianjiao Zhou, Chengzhen Meng & Pingli He. (2019) Soy Isoflavones and their Effects on Xenobiotic Metabolism. Current Drug Metabolism 20:1, pages 46-53.
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Zhe Wang, Li Wang, Meng-ming Xia, Wei Sun, Cheng-ke Huang, Xiao Cui, Guo-xin Hu, Qing-quan Lian & Zeng-shou Wang. (2015) Pharmacokinetics Interaction between Imatinib and Genistein in Rats. BioMed Research International 2015, pages 1-7.
Crossref
Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre & Neal M. Davies. 2012. FLAVONOID PHARMACOKINETICS. FLAVONOID PHARMACOKINETICS 281 319 .
Kerstin Gross-Steinmeyer & David L. Eaton. (2012) Dietary modulation of the biotransformation and genotoxicity of aflatoxin B1. Toxicology 299:2-3, pages 69-79.
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Madhavan Shenbagam & Namasivayam Nalini. (2011) Dose response effect of rutin a dietary antioxidant on alcohol-induced prooxidant and antioxidant imbalance - a histopathologic study. Fundamental & Clinical Pharmacology 25:4, pages 493-502.
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Svjetlana Medjakovic, Monika Mueller & Alois Jungbauer. (2010) Potential Health-modulating Effects of Isoflavones and Metabolites via Activation of PPAR and AhR. Nutrients 2:3, pages 241-279.
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Erik B. Froyen, Jaime L. Rudolf Reeves, Alyson E. Mitchell & Francene M. Steinberg. (2009) Regulation of Phase II Enzymes by Genistein and Daidzein in Male and Female Swiss Webster Mice. Journal of Medicinal Food 12:6, pages 1227-1237.
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Thérèse Sergent, Isabelle Dupont, Edwige Van Der Heiden, Marie-Louise Scippo, Luc Pussemier, Yvan Larondelle & Yves-Jacques Schneider. (2009) CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells. Toxicology Letters 191:2-3, pages 216-222.
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S. Aranganathan, J. Panneer Selvam, N. Sangeetha & N. Nalini. (2009) Modulatory efficacy of hesperetin (citrus flavanone) on xenobiotic-metabolizing enzymes during 1,2-dimethylhydrazine-induced colon carcinogenesis. Chemico-Biological Interactions 180:2, pages 254-261.
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Hesham A. El-Beshbishy, Abdel Nasser B. Singab, Jari Sinkkonen & Kalevi Pihlaja. (2006) Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sciences 78:23, pages 2724-2733.
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Young Jin Moon, Xiaodong Wang & Marilyn E. Morris. (2006) Dietary flavonoids: Effects on xenobiotic and carcinogen metabolism. Toxicology in Vitro 20:2, pages 187-210.
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Martin J. Ronis, Ying Chen, Jamie Badeaux, Elizabeth Laurenzana & Thomas M. Badger. (2016) Soy Protein Isolate Induces CYP3A1 and CYP3A2 in Prepubertal Rats. Experimental Biology and Medicine 231:1, pages 60-69.
Crossref
Mokhtar I. Yousef, Kamel I. Kamel, Alshaimaa M. Esmail & Hoda H. Baghdadi. (2004) Antioxidant activities and lipid lowering effects of isoflavone in male rabbits. Food and Chemical Toxicology 42:9, pages 1497-1503.
Crossref
Gail D. Anderson, Gina Rosito, Michael A. Mohustsy & Gary W. Elmer. (2013) Drug Interaction Potential of Soy Extract and Panax Ginseng. The Journal of Clinical Pharmacology 43:6, pages 643-648.
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W. Scheppach, B. Pool-Zobel & J. Stein. 2003. Praxishandbuch klinische Ernährung und Infusionstherapie. Praxishandbuch klinische Ernährung und Infusionstherapie 870 891 .
Bent H Havsteen. (2002) The biochemistry and medical significance of the flavonoids. Pharmacology & Therapeutics 96:2-3, pages 67-202.
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Petr Hodek, Pavel Trefil & Marie Stiborová. (2002) Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chemico-Biological Interactions 139:1, pages 1-21.
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Shiu-Ming Kuo. 2002. Flavonoids in Cell Function. Flavonoids in Cell Function 191 200 .
Lynnette R. Ferguson. (2001) Role of plant polyphenols in genomic stability. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 475:1-2, pages 89-111.
Crossref
Nuala A Helsby, Shuotun Zhu, Amira E Pearson, Malcolm D Tingle & Lynnette R Ferguson. (2000) Antimutagenic effects of wheat bran diet through modification of xenobiotic metabolising enzymes. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 454:1-2, pages 77-88.
Crossref
Taro Kishida, Kunitaka Nashiki, Toru Izumi & Kiyoshi Ebihara. (2000) Soy Isoflavonoid Aglycons Genistein and Daidzein Do Not Increase the Cytochrome P-450 Content of the Liver Microsomes of Mice. Journal of Agricultural and Food Chemistry 48:9, pages 3872-3875.
Crossref
C.L Miranda, G.L.M Aponso, J.F Stevens, M.L Deinzer & D.R Buhler. (2000) Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells. Cancer Letters 149:1-2, pages 21-29.
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Martin J Ronis, J.Craig Rowlands, Reza Hakkak & Thomas M. Badger. (1999) Altered Expression and Glucocorticoid-Inducibility of Hepatic CYP3A and CYP2B Enzymes in Male Rats Fed Diets Containing Soy Protein Isolate. The Journal of Nutrition 129:11, pages 1958-1965.
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Lisa C. Appelt & Marla M. Reicks. (1999) Soy Induces Phase II Enzymes But Does Not Inhibit Dimethylbenz[a]anthracene-Induced Carcinogenesis in Female Rats. The Journal of Nutrition 129:10, pages 1820-1826.
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HUGH L.J. MAKIN, JANE INCE, CAROLINE TAHOURDIN & ANDREW DUNN. (1999) Government-Funded Phytoestrogen Research in the United Kingdom. Journal of Medicinal Food 2:3-4, pages 275-277.
Crossref
N.A Helsby, J.K Chipman, A Gescher & D Kerr. (1998) Inhibition of Mouse and Human CYP 1A- and 2E1-dependent Substrate Metabolism by the Isoflavonoids Genistein and Equol. Food and Chemical Toxicology 36:5, pages 375-382.
Crossref
CA Musonda, N. Helsby & JK Chipman. (2016) Effects of quercetin on drug metabolizing enzymes and oxidation of 2', 7-dichlorofluorescin in HepG2 cells. Human & Experimental Toxicology 16:12, pages 700-708.
Crossref

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