Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 4
Submit an article Journal homepage
26
Views
14
CrossRef citations to date
0
Altmetric
Research Article

Extension of a predictive substrate model for human cytochrome P4502D6

M. J. DE GROOT Leiden Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemist ry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam and Department of Theoretical Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands
,
G. J. BIJLOO Leiden Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemist ry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam and Department of Theoretical Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands
,
F. A. A. VAN ACKER Leiden Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemist ry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam and Department of Theoretical Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands
,
C. FONSECA GUERRA Leiden Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemist ry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam and Department of Theoretical Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands
&
J. G. SNIJDERS Leiden Amsterdam Center for Drug Research (LACDR), Department of Pharmacochemist ry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam and Department of Theoretical Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081HV, Amsterdam, The Netherlands
Pages 357-368 | Published online: 22 Sep 2008

Citations (14)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Keneuoe Cecilia Nthontho, Andrew Khulekani Ndlovu, Kirthana Sharma, Ishmael Kasvosve, Daniel Louis Hertz & Giacomo Maria Paganotti. (2022) Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective. Pharmacogenomics and Personalized Medicine 15, pages 613-652.
Read now
Bo Wang, Li-Ping Yang, Xiao-Zhuang Zhang, Shui-Qing Huang, Mark Bartlam & Shu-Feng Zhou. (2009) New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme. Drug Metabolism Reviews 41:4, pages 573-643.
Read now
Patricia Neafsey, Gary Ginsberg, Dale Hattis & Babasaheb Sonawane. (2009) Genetic Polymorphism in Cytochrome P450 2D6 (CYP2D6): Population Distribution of CYP2D6 Activity. Journal of Toxicology and Environmental Health, Part B 12:5-6, pages 334-361.
Read now

Articles from other publishers (11)

Ping-ping Lin, Xue-ning Li, Fei Yuan, Wei-li Chen, Meng-jie Yang & Hong-rong Xu. (2016) Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A. Biochemical and Biophysical Research Communications 480:2, pages 248-253.
Crossref
Marcel J. de Groot, Florian Wakenhut, Gavin Whitlock & Ruth Hyland. (2009) Understanding CYP2D6 interactions. Drug Discovery Today 14:19-20, pages 964-972.
Crossref
Larry J. Jolivette & Sean Ekins. 2007. 131 176 .
Chungang Gu, Roxane Collins, Daniel D. Holsworth, Gregory S. Walker & Richard L. Voorman. (2006) Metabolic Aromatization of N -Alkyl-1,2,3,4-Tetrahydroquinoline Substructures to Quinolinium by Human Liver Microsomes and Horseradish Peroxidase . Drug Metabolism and Disposition 34:12, pages 2044-2055.
Crossref
Peter Hlavica. (2006) Functional interaction of nitrogenous organic bases with cytochrome P450: A critical assessment and update of substrate features and predicted key active-site elements steering the access, binding, and orientation of amines. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1764:4, pages 645-670.
Crossref
Chris de Graaf, Nico P. E. Vermeulen & K. Anton Feenstra. (2005) Cytochrome P450 in Silico:  An Integrative Modeling Approach. Journal of Medicinal Chemistry 48:8, pages 2725-2755.
Crossref
Shahriar Haji-Momenian, Jayson M Rieger, Timothy L Macdonald & Milton L Brown. (2003) Comparative molecular field analysis and QSAR on substrates binding to cytochrome P450 2D6. Bioorganic & Medicinal Chemistry 11:24, pages 5545-5554.
Crossref
Marcel J. de Groot & Sean Ekins. (2002) Pharmacophore modeling of cytochromes P450. Advanced Drug Delivery Reviews 54:3, pages 367-383.
Crossref
Sean Ekins, Chris L Waller, Peter W Swaan, Gabriele Cruciani, Steven A Wrighton & James H Wikel. (2000) Progress in predicting human ADME parameters in silico. Journal of Pharmacological and Toxicological Methods 44:1, pages 251-272.
Crossref
Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne, Alexander A. Alex & Barry C. Jones. (1999) A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6. Journal of Medicinal Chemistry 42:20, pages 4062-4070.
Crossref
Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne, Alexander A. Alex & Barry C. Jones. (1999) Novel Approach To Predicting P450-Mediated Drug Metabolism:  Development of a Combined Protein and Pharmacophore Model for CYP2D6. Journal of Medicinal Chemistry 42:9, pages 1515-1524.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.