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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 4
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Research Article

Assessment of rat liver slices as a suitable model system for studying the simultaneous sulphation and glucuronidation of phenolic xenobiotics

E. A. ODDY Department of Molecular & Cellular Pathology, University of Dundee , Ninewells Hospital and Medical School , Dundee DD1 9SY, UK Research BioMet Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
G. R. MANCHEE Department of Molecular & Cellular Pathology, University of Dundee , Ninewells Hospital and Medical School , Dundee DD1 9SY, UK Research BioMet Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
&
M. W. H. COUGHTRIE Department of Molecular & Cellular Pathology, University of Dundee , Ninewells Hospital and Medical School , Dundee DD1 9SY, UK Research BioMet Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
Pages 369-378 | Published online: 22 Sep 2008

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Z. Riches, J. Bloomer, A. Patel, A Nolan & M. Coughtrie. (2009) Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation. Xenobiotica 39:5, pages 374-381.
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D. M. CROSS & M. K. BAYLISS. (2000) A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*. Drug Metabolism Reviews 32:2, pages 219-240.
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Articles from other publishers (13)

Michele M. Skopec & M. Denise Dearing. (2011) Differential expression and activity of catechol-O-methyl transferase (COMT) in a generalist (Neotoma albigula) and juniper specialist (Neotoma stephensi) woodrat. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 154:4, pages 383-390.
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Van T. Ly & Barry Brock. (2011) Effects of CYP inhibitors on precocene I metabolism and toxicity in rat liver slices. Chemico-Biological Interactions 193:2, pages 109-118.
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Valérie Wauthier, Roger K. Verbeeck & Pedro Buc Calderon. (2004) The use of precision-cut liver slices from male Wistar rats as a tool to study age related changes in CYP3A induction and in formation of paracetamol conjugates. Toxicology in Vitro 18:6, pages 879-885.
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Michael Coughtrie & Michael Fisher. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 541 575 .
E Evdokimova, H Taper & P Buc Calderon. (2002) Effects of bacterial endotoxin (lipopolysaccharides) on survival and metabolism of cultured precision-cut rat liver slices. Toxicology in Vitro 16:1, pages 47-54.
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E. Evdokimova, H. Taper & P. Buc Calderon. (2001) Role of ATP and glycogen reserves in both paracetamol sulfation and glucuronidation by cultured precision-cut rat liver slices. Toxicology in Vitro 15:6, pages 683-690.
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Norbert Staimer, Shirley J Gee & Bruce D Hammock. (2001) Development of a class-selective enzyme immunoassay for urinary phenolic glucuronides. Analytica Chimica Acta 444:1, pages 27-36.
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Jennifer L. Donovan, Vanessa Crespy, Claudine Manach, Christine Morand, Catherine Besson, Augustin Scalbert & Christian Rémésy. (2001) Catechin Is Metabolized by Both the Small Intestine and Liver of Rats. The Journal of Nutrition 131:6, pages 1753-1757.
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U.D. Kuhn, M. Rost & D. Müller. (2001) Para-nitrophenol glucuronidation and sulfation in rat and human liver slices. Experimental and Toxicologic Pathology 53:1, pages 81-88.
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Andrea J Day, Yongping Bao, Michael R.A Morgan & Gary Williamson. (2000) Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biology and Medicine 29:12, pages 1234-1243.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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G.D Bowers, M.K Bayliss, M.C Donnelly, I Fellows, I.M Ismail & C.R Mookherjee. (1998) The characterisation of the major metabolite of salmeterol in the dog. Journal of Pharmaceutical and Biomedical Analysis 18:3, pages 461-470.
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Michael W.H Coughtrie, Sheila Sharp, Kaera Maxwell & Nicola P Innes. (1998) Biology and function of the reversible sulfation pathway catalysed by human sulfotransferases and sulfatases. Chemico-Biological Interactions 109:1-3, pages 3-27.
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