Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 3
18
Views
24
CrossRef citations to date
0
Altmetric
Research Article

A hypothetical model for the active site of human cytochrome P4502E1

, , &
Pages 287-299 | Published online: 22 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Yasushi Yamazoe, Kazumi Ito & Kouichi Yoshinari. (2011) Construction of a CYP2E1-template system for prediction of the metabolism on both site and preference order. Drug Metabolism Reviews 43:4, pages 409-439.
Read now
Grover P Miller. (2008) Advances in the interpretation and prediction of CYP2E1 metabolism from a biochemical perspective. Expert Opinion on Drug Metabolism & Toxicology 4:8, pages 1053-1064.
Read now
Jose M Jimenez-Lopez & Arthur I Cederbaum. (2005) CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 1:4, pages 671-685.
Read now

Articles from other publishers (19)

Samuel L. Collom, Ryan M. Laddusaw, Amber M. Burch, Petr Kuzmic, Martin D. PerryJr.Jr. & Grover P. Miller. (2008) CYP2E1 Substrate Inhibition. Journal of Biological Chemistry 283:6, pages 3487-3496.
Crossref
Jack Uetrecht & William Trager. 2007. Drug Metabolism. Drug Metabolism 33 108 .
I. M. Danko & N. A. Chaschin. (2007) Structure-functional characterization of cytochrome P4502E1 (CYP2E1). Biopolymers and Cell 23:2, pages 67-85.
Crossref
Samuel L. Collom, Arvind P. Jamakhandi, Alan J. Tackett, Anna Radominska-Pandya & Grover P. Miller. (2007) CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling. Archives of Biochemistry and Biophysics 459:1, pages 59-69.
Crossref
Yong Wang, Chuanlu Yang , Hongming Wang, Keli Han  & Sason Shaik. (2007) A New Mechanism for Ethanol Oxidation Mediated by Cytochrome P450 2E1: Bulk Polarity of the Active Site Makes a Difference. ChemBioChem 8:3, pages 277-281.
Crossref
Anna L. Blobaum. (2006) MECHANISM-BASED INACTIVATION AND REVERSIBILITY: IS THERE A NEW TREND IN THE INACTIVATION OF CYTOCHROME P450 ENZYMES?. Drug Metabolism and Disposition 34:1, pages 1-7.
Crossref
Destiny M. Davenport & Michael J. Wargovich. (2005) Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. Food and Chemical Toxicology 43:12, pages 1753-1762.
Crossref
Carol A. Kemp, Jean-Didier Maréchal & Michael J. Sutcliffe. (2005) Progress in cytochrome P450 active site modeling. Archives of Biochemistry and Biophysics 433:2, pages 361-368.
Crossref
F. Peter Guengerich. 2005. Cytochrome P450. Cytochrome P450 377 530 .
Brad Reisfeld & Raymond S.H. Yang. (2004) A reaction network model for CYP2E1-mediated metabolism of toxicant mixtures. Environmental Toxicology and Pharmacology 18:2, pages 173-179.
Crossref
A. L. Blobaum. (2004) Novel Reversible Inactivation of Cytochrome P450 2E1 T303A by tert-Butyl Acetylene: The Role of Threonine 303 in Proton Delivery to the Active Site of Cytochrome P450 2E1. Journal of Pharmacology and Experimental Therapeutics 310:1, pages 281-290.
Crossref
D.F.V Lewis, B.G Lake, M.G Bird, G.D Loizou, M Dickins & P.S Goldfarb. (2003) Homology modelling of human CYP2E1 based on the CYP2C5 crystal structure: investigation of enzyme–substrate and enzyme–inhibitor interactions. Toxicology in Vitro 17:1, pages 93-105.
Crossref
Stewart B Kirton, Carol A Baxter & Michael J Sutcliffe. (2002) Comparative modelling of cytochromes P450. Advanced Drug Delivery Reviews 54:3, pages 385-406.
Crossref
David Lewis. 2001. Guide to Cytochromes P450. Guide to Cytochromes P450 164 210 .
Rosa L. Moreno, Theunis Goosen, Ute M. Kent, Fung-Lung Chung & Paul F. Hollenberg. (2001) Differential Effects of Naturally Occurring Isothiocyanates on the Activities of Cytochrome P450 2E1 and the Mutant P450 2E1 T303A. Archives of Biochemistry and Biophysics 391:1, pages 99-110.
Crossref
F Adas, F Berthou, J.P Salaün, Y Dréano & Y Amet. (1999) Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A. Toxicology Letters 110:1-2, pages 43-55.
Crossref
Renke Dai, Suoping Zhai, Xiaoxiong Wei, Matthew R. Pincus, Robert E. Vestal & Fred K. Friedman. (1998) Inhibition of human cytochrome P450 1A2 by flavones: A molecular modeling study. Journal of Protein Chemistry 17:7, pages 643-650.
Crossref
Fadi Adas, François Berthou, Daniel Picart, Patrick Lozac'h, Françoise Beaugé & Yolande Amet. (1998) Involvement of cytochrome P450 2E1 in the (ω–1)-hydroxylation of oleic acid in human and rat liver microsomes. Journal of Lipid Research 39:6, pages 1210-1219.
Crossref
F.Peter Guengerich. (1997) Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species. Chemico-Biological Interactions 106:3, pages 161-182.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.