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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 2
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Research Article

Cytochrome P4501A(CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan

A. P. BERESFORD* Bioanalysis and Metabolism Division, Clinical Pharmacology Department, GlaxoWellcome Research and Development, Ware SG12 0DP, UK Molecular Toxicology Group , School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
,
W. J. ELLIS Bioanalysis and Metabolism Division, Clinical Pharmacology Department, GlaxoWellcome Research and Development, Ware SG12 0DP, UK Molecular Toxicology Group , School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
,
J. AYRTON Bioanalysis and Metabolism Division, Clinical Pharmacology Department, GlaxoWellcome Research and Development, Ware SG12 0DP, UK Molecular Toxicology Group , School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
,
M. A. JOHNSON Bioanalysis and Metabolism Division, Clinical Pharmacology Department, GlaxoWellcome Research and Development, Ware SG12 0DP, UK Molecular Toxicology Group , School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
&
D. F. V. LEWIS Bioanalysis and Metabolism Division, Clinical Pharmacology Department, GlaxoWellcome Research and Development, Ware SG12 0DP, UK Molecular Toxicology Group , School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
Pages 159-173 | Published online: 22 Sep 2008

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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (4)

Liwei Hu, Wen Xu, Xi Zhang, Juan Su, Xinru Liu, Haiyun Li & Weidong Zhang. (2010) In-vitro and in-vivo evaluations of cytochrome P450 1A2 interactions with nuciferine. Journal of Pharmacy and Pharmacology 62:5, pages 658-662.
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Shaoyu Zhang, Naining Song, Quansheng Li, Huirong Fan & Changxiao Liu. (2008) Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats. Journal of Chromatography B 871:1, pages 78-89.
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D FV LewisM G Bird & M N Jacobs. (2016) Human carcinogens: an evaluation study via the COMPACT and HazardExpert procedures. Human & Experimental Toxicology 21:3, pages 115-122.
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David F.V. Lewis, Brian G. Lake, Stephen G. George, Maurice Dickins, Peter J. Eddershaw, Michael H. Tarbit, Alan P. Beresford, Peter S. Goldfarb & F.Peter Guengerich. (1999) Molecular modelling of CYP1 family enzymes CYP1A1, CYP1A2, CYP1A6 and CYP1B1 based on sequence homology with CYP102. Toxicology 139:1-2, pages 53-79.
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