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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 2
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Research Article

Metabolism and pharmacokinetics of barnidipine hydrochloride, a calcium channel blocker, in man following oral administration of its sustained release formulation

T. TERAMURA* Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd, 1-8, Azusawa 1- chome, Itabashi - ku, Tokyo 174, Japan
,
T. WATANABE Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd, 1-8, Azusawa 1- chome, Itabashi - ku, Tokyo 174, Japan
,
S. HIGUCHI Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd, 1-8, Azusawa 1- chome, Itabashi - ku, Tokyo 174, Japan
&
K. HASHIMOTO Drug Metabolism Department, Clinical Pharmacology Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd, 1-8, Azusawa 1- chome, Itabashi - ku, Tokyo 174, Japan
Pages 203-216 | Published online: 22 Sep 2008

Citations (8)

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Read on this site (2)

Chiau-Suong Liau. (2005) Barnidipine: a new calcium channel blocker for hypertension treatment. Expert Review of Cardiovascular Therapy 3:2, pages 207-213.
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T. TERAMURA*Y. FUKUNAGA, E. J. VAN HOOGDALEM, T. WATANABE & S. HIGUCHI. (1997) Examination of metabolic pathways and identification of human liver cytochrome P450 isozymes responsible for the metabolism of barnidipine, a calcium channel blocker. Xenobiotica 27:9, pages 885-900.
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Articles from other publishers (6)

Ruina Gao. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 4 .
Dezhi Kong, Sanni Li, Xiaowei Zhang, Jianmin Gu, Man Liu, Yan Meng, Yan Fu, Xiaojin La, Gangqiang Xue, Lantong Zhang & Qiao Wang. (2010) Simultaneous determination of m-nisoldipine and its three metabolites in rat plasma by liquid chromatography–mass spectrometry. Journal of Chromatography B 878:29, pages 2989-2996.
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S Bohlooli, M Mahmoudian, G G Skellern, M H Grant & J N A Tettey. (2004) Metabolism of the dihydropyridine calcium channel blockers mebudipine and dibudipine by isolated rat hepatocytes. Journal of Pharmacy and Pharmacology 56:11, pages 1469-1475.
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Yune-Jung Yoon, Kwon-Bok Kim, Hyunmi Kim, Kyung-Ah Seo, Ho-Sook Kim, In-June Cha, Eun-Young Kim, Kwang-Hyeon Liu & Jae-Gook Shin. (2007) Characterization of Benidipine and Its Enantiomers' Metabolism by Human Liver Cytochrome P450 Enzymes. Drug Metabolism and Disposition 35:9, pages 1518-1524.
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W Zhu, T Li, C Ni, H Liu, L Fang, M Shang, T Kikkawa, H Katoh & M Yamamoto. (2016) Comparative Study of Barnidipine and Felodipine in Chinese Patients with Essential Hypertension. Journal of International Medical Research 34:4, pages 406-412.
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M. Pawula, D. Watson, T. Teramura, T. Watanabe, S. Higuchi & K.N. Cheng. (1998) Sensitive and specific liquid chromatographic–tandem mass spectrometric assay for barnidipine in human plasma. Journal of Chromatography B: Biomedical Sciences and Applications 719:1-2, pages 113-123.
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