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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 1
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Research Article

Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line

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Pages 1-9 | Published online: 22 Sep 2008

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S. Krusekopf, I. Roots, A. G. Hildebrandt & U. Kleeberg. (2003) Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+-ATPase inhibitors and other xenobiotics. Xenobiotica 33:2, pages 107-118.
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Q. Feng, T. Kumagai, Y. Nakamura, K. Uchida & T. Osawa. (2002) Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells. Xenobiotica 32:11, pages 1033-1043.
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ULLRICH KLEEBERG, ROLAND FRÖTSCHL, SOLVEIGH KRUSEKOPF, JÜRGEN BROCKMÖLLER, IVAR ROOTS, KLAUS RUCKPAUL & ALFRED G. HILDEBRANDT. (1999) INDUCTION OF CYP1A BY VARIOUS BENZIMIDAZOLES AND ITS SIGNIFICANCE IN ADMINISTRATIVE DRUG REGULATION. Drug Metabolism Reviews 31:2, pages 381-392.
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Articles from other publishers (28)

Carolina Nicolau, Alyson Prorock, Yongde Bao, Ana Neves-Ferreira, Richard Valente & Jay Fox. (2018) Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping. Toxins 10:2, pages 69.
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Kazuhiro Shiizaki, Masanobu Kawanishi & Takashi Yagi. (2014) Microbial Metabolites of Omeprazole Activate Murine Aryl Hydrocarbon Receptor In Vitro and In Vivo. Drug Metabolism and Disposition 42:10, pages 1690-1697.
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Kazuhiro Shiizaki, Seiichiroh Ohsako, Masanobu Kawanishi & Takashi Yagi. (2014) Identification of Amino Acid Residues in the Ligand-Binding Domain of the Aryl Hydrocarbon Receptor Causing the Species-Specific Response to Omeprazole: Possible Determinants for Binding Putative Endogenous Ligands. Molecular Pharmacology 85:2, pages 279-289.
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Alexander V. LyubimovJiunn H. Lin & Jianjun Guo. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 21 .
Issa E.A. Amara & Ayman O.S. El-Kadi. (2011) Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells. Free Radical Biology and Medicine 51:9, pages 1675-1685.
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Binoy Shivanna, Weiwu Jiang, Lihua Wang, Xanthi I. Couroucli & Bhagavatula Moorthy. (2011) Omeprazole Attenuates Hyperoxic Lung Injury in Mice via Aryl Hydrocarbon Receptor Activation and Is Associated with Increased Expression of Cytochrome P4501A Enzymes. Journal of Pharmacology and Experimental Therapeutics 339:1, pages 106-114.
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Kevin C. Brown & Angela D. M. Kashuba. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 11 41 .
Issa E.A. Amara, Anwar Anwar-Mohamed & Ayman O.S. El-Kadi. (2010) Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells. Toxicology Letters 199:3, pages 225-233.
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Ghada Abdelhamid, Anwar Anwar-Mohamed, Osama A. Badary, Adel A. Moustafa & Ayman O.S. El-Kadi. (2010) Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells. Cell Biology and Toxicology 26:5, pages 421-434.
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Kazuaki Matsuoka-Kawano, Kouichi Yoshinari, Sekio Nagayama & Yasushi Yamazoe. (2010) TSU-16, (Z)-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone, is a potent activator of aryl hydrocarbon receptor and increases CYP1A1 and CYP1A2 expression in human hepatocytes. Chemico-Biological Interactions 185:1, pages 33-41.
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V Baliharová, L Skálová, R F M Maas, G de Vrieze, S Bull & J Fink-Gremmels. (2003) The effects of mebendazole on P4501A activity in rat hepatocytes and HepG2 cells. Comparison with tiabendazole and omeprazole. Journal of Pharmacy and Pharmacology 55:6, pages 773-781.
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Jiunn H. Lin. (2006) CYP Induction-Mediated Drug Interactions: in Vitro Assessment and Clinical Implications. Pharmaceutical Research 23:6, pages 1089-1116.
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Xin-jiang Wu, Wen-qing Lu, Peter H. Roos & Volker Mersch-Sundermann. (2005) Vinclozolin, a widely used fungizide, enhanced BaP-induced micronucleus formation in human derived hepatoma cells by increasing CYP1A1 expression. Toxicology Letters 159:1, pages 83-88.
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Ralph Menzel, Matthias Rödel, Jana Kulas & Christian E.W. Steinberg. (2005) CYP35: Xenobiotically induced gene expression in the nematode Caenorhabditis elegans. Archives of Biochemistry and Biophysics 438:1, pages 93-102.
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P.F. Dehn, S. Allen-Mocherie, J. Karek & A. Thenappan. (2005) Organochlorine insecticides: impacts on human HepG2 cytochrome P4501A, 2B activities and glutathione levels. Toxicology in Vitro 19:2, pages 261-273.
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Jiřı́ Vrba, Pavel Kosina, Jitka Ulrichová & Martin Modrianský. (2004) Involvement of cytochrome P450 1A in sanguinarine detoxication. Toxicology Letters 151:2, pages 375-387.
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J Velı́k, V Baliharová, J Fink-Gremmels, S Bull, J Lamka & L Skálová. (2004) Benzimidazole drugs and modulation of biotransformation enzymes. Research in Veterinary Science 76:2, pages 95-108.
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Sue Hyung Choi, Osamu Fukuda, Akiyoshi Sakoda & Yasuyuki Sakai. (2004) Enhanced cytochrome P450 capacities of Caco-2 and Hep G2 cells in new coculture system under the static and perfused conditions: evidence for possible organ-to-organ interactions against exogenous stimuli. Materials Science and Engineering: C 24:3, pages 333-339.
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V. Baliharová, L. Skálová, R.F.M. Maas, G. De Vrieze, S. Bull & J. Fink-Gremmels. (2003) The effects of benzimidazole anthelmintics on P4501A in rat hepatocytes and HepG2 cells. Research in Veterinary Science 75:1, pages 61-69.
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Solveigh Krusekopf, Ivar Roots & Ullrich Kleeberg. (2003) Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43. European Journal of Pharmacology 466:1-2, pages 7-12.
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Volker Mersch-Sundermann, Heidi Schneider, Christian Freywald, Cornelia Jenter, Wolfram Parzefall & Siegfried Knasmüller. (2001) Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 495:1-2, pages 89-96.
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Angela D. M. Kashuba & Joseph S. Bertino. 2001. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 13 38 .
Dennis L. Avner. (2000) Clinical experience with pantoprazole in gastroesophageal reflux disease. Clinical Therapeutics 22:10, pages 1169-1185.
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E Alexandre, P David, C Viollon, P Wolf, D Jaeck, A Azimzadeh, L Nicod, K Boudjema & L Richert. (1999) Expression of Cytochromes P-450 2E1, 3A4 and 1A1/1A2 in Growing and Confluent Human HepG2 Hepatoma Cells—Effect of Ethanol. Toxicology in Vitro 13:3, pages 427-435.
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Karl-Uwe Petersen. 1999. Proton Pump Inhibitors. Proton Pump Inhibitors 143 157 .
Roland Frötschl, Lubomir Chichmanov, Ullrich Kleeberg, Alfred G. Hildebrandt, Ivar Roots & Jürgen Brockmöller. (1998) Prediction of Aryl Hydrocarbon Receptor-Mediated Enzyme Induction of Drugs and Chemicals by mRNA Quantification. Chemical Research in Toxicology 11:12, pages 1447-1452.
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Noriko Masubuchi, Albert P Li & Osamu Okazaki. (1998) An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Chemico-Biological Interactions 114:1-2, pages 1-13.
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David F.V. Lewis & Brian G. Lake. (1998) Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes. Toxicology 125:1, pages 31-44.
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