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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 1
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Research Article

Biological fate of sulphur mustard : in vitro alkylation of human haemoglobin by sulphur mustard

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Pages 11-32 | Published online: 22 Sep 2008

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Gemechu Yigezu Ofgeha & Muluneh Woldetsadik Abshire. (2022) Structural land use dynamics and its implications on the local community’s access to land resources in Anger watershed, Southwestern Ethiopia. African Geographical Review 41:4, pages 516-530.
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Leila Etemad, Mohammad Moshiri & Mahdi Balali-Mood. (2019) Advances in treatment of acute sulfur mustard poisoning – a critical review. Critical Reviews in Toxicology 49:3, pages 191-214.
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ChristopherM. Timperley, RobinM. Black, Michael Bird, Ian Holden, JoannaL. Mundy & RobertW. Read. (2003) Hydrolysis and Oxidation Products of the Chemical Warfare Agents 1,2-Bis[(2-chloroethyl)thio]ethane Q and 2,2′-Bis(2-chloroethylthio)diethyl Ether T. Phosphorus, Sulfur, and Silicon and the Related Elements 178:9, pages 2027-2046.
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Articles from other publishers (33)

Bo Chen, Zhe Ren, Tao Zhang, Huilan Yu, ZhiBin Shu, Changcai Liu, Yang Yang, Ping Xu & Shilei Liu. (2022) Simultaneous quantification of multiple amino acid adducts from sulfur mustard-modified human serum albumin in plasma at trace exposure levels by ultra-high performance liquid chromatography–triple quadrupole mass spectrometry after propionyl derivatization. Journal of Chromatography A 1678, pages 463354.
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Bo Chen, Qiaoli Zhang, Zhe Ren, Tao Zhang, Huilan Yu, Changcai Liu, Yang Yang, Ping Xu & Shilei Liu. (2022) A proteomics strategy for the identification of multiple sites in sulfur mustard–modified HSA and screening potential biomarkers for retrospective analysis of exposed human plasma. Analytical and Bioanalytical Chemistry 414:14, pages 4179-4188.
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Florine Hallez, Audrey Combès, Charlotte Desoubries, Anne Bossée & Valérie Pichon. (2022) Analysis of long-lived sulfur mustard-human hemoglobin adducts in blood samples by red blood cells lysis and on-line coupling of digestion on an immobilized-trypsin reactor with liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1665, pages 462830.
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Florine Hallez, Audrey Combès, Charlotte Desoubries, Anne Bossée & Valérie Pichon. (2021) Development of an immobilized-trypsin reactor coupled to liquid chromatography and tandem mass spectrometry for the analysis of human hemoglobin adducts with sulfur mustard. Journal of Chromatography B 1186, pages 123031.
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Dirk Steinritz, Robin Lüling, Markus Siegert, Julia Herbert, Harald Mückter, Christian D. Taeger, Thomas Gudermann, Alexander Dietrich, Horst Thiermann & Harald John. (2021) Alkylated epidermal creatine kinase as a biomarker for sulfur mustard exposure: comparison to adducts of albumin and DNA in an in vivo rat study. Archives of Toxicology 95:4, pages 1323-1333.
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Florine Hallez, Audrey Combès, Charlotte Desoubries, Anne Bossée & Valérie Pichon. (2021) Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the analysis of tryptic digest of human hemoglobin exposed to sulfur mustard. Journal of Chromatography B 1163, pages 122518.
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Daan Noort, Marcel J. van der Schans & Robin M. Black. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry 1 21 .
M.J. van der Schans. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 969 981 .
Harald John, Frank Balszuweit, Dirk Steinritz, Kai Kehe, Franz Worek & Horst Thiermann. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 875 919 .
Bo Chen, Hui-Lan Yu, Shi-Lei Liu, Chang-Cai Liu, Long-Hui Liang, Xin-Hai Li, Xiao-Sen Li, Ji-Na Wu & Yang Yang. (2019) A sensitive quantification approach for detection of HETE-CP adduct after benzyl chloroformate derivatization using ultra-high-pressure liquid chromatography tandem mass spectrometry. Analytical and Bioanalytical Chemistry 411:15, pages 3405-3415.
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Andreas Bielmann, Nicolas Sambiagio, Nathalie Wehr, Sandrine Gerber-Lemaire, Christian G. Bochet & Christophe Curty. (2018) Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers. RSC Advances 8:42, pages 23881-23890.
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Hua Xu, Zhongcai Gao, Peng Wang, Bin Xu, Yajiao Zhang, Long Long, Cheng Zong, Lei Guo, Weijian Jiang, Qinong Ye, Lili Wang & Jianwei Xie. (2018) Biological effects of adipocytes in sulfur mustard induced toxicity. Toxicology 393, pages 140-149.
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Bin Xu, Cheng Zong, Yajiao Zhang, Tianhong Zhang, Xiaoying Wang, Meiling Qi, Jianfeng Wu, Lei Guo, Peng Wang, Jia Chen, Qin Liu, Hua Xu, Jianwei Xie & Zhenqing Zhang. (2016) Accumulation of intact sulfur mustard in adipose tissue and toxicokinetics by chemical conversion and isotope-dilution liquid chromatography–tandem mass spectrometry. Archives of Toxicology 91:2, pages 735-747.
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Dirk Steinritz & Horst Thiermann. 2017. Critical Care Toxicology. Critical Care Toxicology 2683 2712 .
Harald John, Markus Siegert, Felix Gandor, Michael Gawlik, Andreas Kranawetvogl, Konstantin Karaghiosoff & Horst Thiermann. (2016) Optimized verification method for detection of an albumin-sulfur mustard adduct at Cys34 using a hybrid quadrupole time-of-flight tandem mass spectrometer after direct plasma proteolysis. Toxicology Letters 244, pages 103-111.
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Dirk Steinritz & Horst Thiermann. 2016. Critical Care Toxicology. Critical Care Toxicology 1 30 .
Jin Young Lee & Yong Han Lee. (2015) Solid-Phase Extraction of Sulfur Mustard Metabolites Using an Activated Carbon Fiber Sorbent. Journal of Analytical Toxicology, pages bkv112.
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Harald John, Frank Balszuweit, Kai Kehe, Franz Worek & Horst Thiermann. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 817 856 .
D. Thavaselvam & Swaran S. Flora. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 521 538 .
O. I. Orlova, E. I. Savel’eva & N. S. Khlebnikova. (2012) Methods for the detection of sulfur mustard metabolites in biological materials: An analytical review. Journal of Analytical Chemistry 68:1, pages 1-11.
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Mia Halme, Maaret Karjalainen, Harri Kiljunen & Paula Vanninen. (2011) Development and validation of efficient stable isotope dilution LC–HESI–MS/MS method for the verification of β-lyase metabolites in human urine after sulfur mustard exposure. Journal of Chromatography B 879:13-14, pages 908-914.
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Robert W. Read. 2011. Detection of Biological Agents for the Prevention of Bioterrorism. Detection of Biological Agents for the Prevention of Bioterrorism 201 219 .
J. Richard Smith & Benedict R. Capacio. 2011. Detection of Biological Agents for the Prevention of Bioterrorism. Detection of Biological Agents for the Prevention of Bioterrorism 181 199 .
Robin M. Black. (2010) History and perspectives of bioanalytical methods for chemical warfare agent detection. Journal of Chromatography B 878:17-18, pages 1207-1215.
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Harald John, Frank Balszuweit, Kai Kehe, Franz Worek & Horst Thiermann. 2009. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 755 790 .
Julian Haigh, Richard Gordon, Benedict Capacio, John Barr, Brian Lukey & J Richard Smith. 2007. Chemical Warfare Agents. Chemical Warfare Agents.
Barbora Papoušková, Petr Bednář, Petr Barták, Petr Fryčák, Juraj Ševčík, Zdeněk Stránský & Karel Lemr. (2006) Utilisation of separation methods in the analysis of chemical warfare agents. Journal of Separation Science 29:11, pages 1531-1538.
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Shigeyuki Hanaoka. 2005. Drugs and Poisons in Humans. Drugs and Poisons in Humans 69 90 .
Kouichiro Tsuge & Yasuo Seto. (2002) Analysis of organophosphorus compound adducts of serine proteases by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 776:1, pages 79-88.
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Daan Noort & Robin M. Black. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry 1 18 .
Robin M. Black & Robert W. Read. 2007. Encyclopedia of Analytical Chemistry. Encyclopedia of Analytical Chemistry.
Daan Noort, Albert G. Hulst, Leo P. A. de Jong & Hendrik P. Benschop. (1999) Alkylation of Human Serum Albumin by Sulfur Mustard in Vitro and in Vivo:  Mass Spectrometric Analysis of a Cysteine Adduct as a Sensitive Biomarker of Exposure. Chemical Research in Toxicology 12:8, pages 715-721.
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R. Bakbtiar, K.H. Leung, R.A. Stearns & C.E.C.A. Hop. (1997) Evidence for a novel heme adduct generated by the in vitro reaction of 2,4,6-trinitrotoluene with human hemoglobin using electrospray ionization mass spectrometry. Journal of Inorganic Biochemistry 68:4, pages 273-278.
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