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Xenobiotica
the fate of foreign compounds in biological systems
Volume 27, 1997 - Issue 1
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Research Article

Metabolism of amitriptyline with CYP2D6 expressed in a human cell line

R. T. Coutts Neurochemical Research Unit, Faculty of Pharmacy and Pharmaceutical Sciences, and Department of Psychiatry, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
,
Mimi V. Bach Neurochemical Research Unit, Faculty of Pharmacy and Pharmaceutical Sciences, and Department of Psychiatry, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
&
G. B. Baker Neurochemical Research Unit, Faculty of Pharmacy and Pharmaceutical Sciences, and Department of Psychiatry, University of Alberta, Edmonton, Alberta T6G 2N8, Canada
Pages 33-47 | Published online: 22 Sep 2008

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Włladyslława Anna Daniel. (2005) The influence of long-term treatment with psychotropic drugs on cytochrome P450: the involvement of different mechanisms. Expert Opinion on Drug Metabolism & Toxicology 1:2, pages 203-217.
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Ai‐Ming Yu, Jeffrey R. Idle & Frank J. Gonzalez. (2004) Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates. Drug Metabolism Reviews 36:2, pages 243-277.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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MIMI V. BACH, R. T. COUTTS & G. B. BAKER. (1999) Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica 29:7, pages 719-732.
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Articles from other publishers (14)

Albert P. Li. 2021. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity. Transporters and Drug‐Metabolizing Enzymes in Drug Toxicity 79 137 .
Amitava Dasgupta & Matthew D. Krasowski. 2020. Therapeutic Drug Monitoring Data. Therapeutic Drug Monitoring Data 199 227 .
Jeffrey P. Walterscheid & Terry J. Danielson. 2012. Handbook of Drug Interactions. Handbook of Drug Interactions 193 214 .
Grzegorz Nałęcz-Jawecki. (2007) In Vitro Biotransformation of Amitriptyline and Imipramine with Rat Hepatic S9 Fraction: Evaluation of the Toxicity with Spirotox and Thamnotoxkit F™ Tests. Archives of Environmental Contamination and Toxicology 54:2, pages 266-273.
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K. A. Rittenbach & G. B. Baker. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 1 16 .
Yona Amitai & Henri Frischer. (2004) Excess Fatality from Desipramine and Dosage Recommendations. Therapeutic Drug Monitoring 26:5, pages 468-473.
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Terry J. Danielson. 2004. Handbook of Drug Interactions. Handbook of Drug Interactions 149 173 .
E. Tanaka. (2003) Toxicological interactions involving psychiatric drugs and alcohol: an update. Journal of Clinical Pharmacy and Therapeutics 28:2, pages 81-95.
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F. Peter Guengerich, Imad H. Hanna, Martha V. Martin & Elizabeth M. J. Gillam. (2003) Role of Glutamic Acid 216 in Cytochrome P450 2D6 Substrate Binding and Catalysis. Biochemistry 42:5, pages 1245-1253.
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Kazutaka Shimoda, Toshiyuki Someya, Aya Yokono, Sachiyo Morita, Genta Hirokane, Saburo Takahashi & Masako Okawa. (2002) The Impact of CYP2C19 and CYP2D6 Genotypes on Metabolism of Amitriptyline in Japanese Psychiatric Patients. Journal of Clinical Psychopharmacology 22:4, pages 371-378.
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Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne, Alexander A. Alex & Barry C. Jones. (1999) A Novel Approach to Predicting P450 Mediated Drug Metabolism. CYP2D6 Catalyzed N-Dealkylation Reactions and Qualitative Metabolite Predictions Using a Combined Protein and Pharmacophore Model for CYP2D6. Journal of Medicinal Chemistry 42:20, pages 4062-4070.
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Marcel J. de Groot, Mark J. Ackland, Valerie A. Horne, Alexander A. Alex & Barry C. Jones. (1999) Novel Approach To Predicting P450-Mediated Drug Metabolism:  Development of a Combined Protein and Pharmacophore Model for CYP2D6. Journal of Medicinal Chemistry 42:9, pages 1515-1524.
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Susan Rotzinger, Jian Fang, Ronald T Coutts & Glen B Baker. (1998) Human CYP2D6 and metabolism of m-chlorophenylpiperazine. Biological Psychiatry 44:11, pages 1185-1191.
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Karthik Venkatakrishnan, David J. Greenblatt, Lisa L. von Moltke, Jürgen Schmider, Jerold S. Harmatz & Richard I. Shader. (2013) Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro : Dominance of CYP 2C19 and 3A4 . The Journal of Clinical Pharmacology 38:2, pages 112-121.
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