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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 11
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Research Article

Trimethadione metabolism by human liver cytochrome P450: evidence for the involvement of CYP2E1

N. KURATA Department of Pharmacology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan OE Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto M5S 1A8, Canada
Pages 1041-1047 | Published online: 22 Sep 2008

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Katherine Walker, Dale Hattis, Abel Russ, Bob Sonawane & Gary Ginsberg. (2007) Approaches to Acrylamide Physiologically Based Toxicokinetic Modeling for Exploring Child–adult Dosimetry Differences. Journal of Toxicology and Environmental Health, Part A 70:24, pages 2033-2055.
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M. D. Lee, E. Ayanoglu & L. Gong. (2006) Drug-induced changes in P450 enzyme expression at the gene expression level: A new dimension to the analysis of drug–drug interactions. Xenobiotica 36:10-11, pages 1013-1080.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Xiao-Ping Chen, Xing-Mei Han, Chang-Hong Jiang, Song-Lin Huang, Zhao-Qian Liu, Bing Zhu, Gan Zhou & Hong-Hao Zhou. (2002) Phenotype distribution and gender-related differences of CYP2E1 activity in a Chinese population. Xenobiotica 32:11, pages 1053-1062.
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Articles from other publishers (11)

Yasushi Yamazoe, Yoshiya Yamamura & Kouichi Yoshinari. (2024) Construction of a fused grid-based CYP2C8-Template system and the application. Drug Metabolism and Pharmacokinetics 55, pages 100492.
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Janne T. Backman, Anne M. Filppula, Mikko Niemi & Pertti J. Neuvonen. (2015) Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 68:1, pages 168-241.
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J. Caroline English, Virunya S. Bhat, Gwendolyn L. Ball & Clifton J. McLellan. (2012) Establishing a total allowable concentration of o-toluidine in drinking water incorporating early lifestage exposure and susceptibility. Regulatory Toxicology and Pharmacology 64:2, pages 269-284.
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Stefan Weigt, Nicole Huebler, Ruben Strecker, Thomas Braunbeck & Thomas H. Broschard. (2011) Zebrafish (Danio rerio) embryos as a model for testing proteratogens. Toxicology 281:1-3, pages 25-36.
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Shu-Feng Zhou, Zhi-Wei Zhou & Min Huang. (2010) Polymorphisms of human cytochrome P450 2C9 and the functional relevance. Toxicology 278:2, pages 165-188.
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Gary Ginsberg, Dale Hattis & Babasaheb Sonawane. (2004) Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants. Toxicology and Applied Pharmacology 198:2, pages 164-183.
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J.L.C.M Dorne, K Walton & A.G Renwick. (2004) Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation). Food and Chemical Toxicology 42:3, pages 397-421.
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Yuki Nishimura, Norimitsu Kurata, Eriko Sakurai & Hajime Yasuhara. (2004) Inhibitory Effect of Antituberculosis Drugs on Human Cytochrome P450-Mediated Activities. Journal of Pharmacological Sciences 96:3, pages 293-300.
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E. Tanaka, N. Kurata & H. Yasuhara. (2003) Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. Journal of Clinical Pharmacy and Therapeutics 28:6, pages 493-496.
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Danièle Lucas. 2003. Reviews in Food and Nutrition Toxicity. Reviews in Food and Nutrition Toxicity 284 304 .
Tanaka, Terada & Misawa. (2000) Cytochrome P450 2E1: its clinical and toxicological role. Journal of Clinical Pharmacy and Therapeutics 25:3, pages 165-175.
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