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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 10
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Research Article

Xenobiotic-metabolizing enzymes in pig nasal and hepatic tissues

Pages 923-935 | Published online: 22 Sep 2008

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Russell Jones, Michaela Marschmann, Michael Keller, Na Hong Qiu, Stephen Fowler, Thomas Singer, Franz Schuler, Christoph Funk & Simone Schadt. (2016) Shedding light on minipig drug metabolism – elevated amide hydrolysis in vitro. Xenobiotica 46:6, pages 483-494.
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M. Boiani, A. Merlino, A. Gerpe, W. Porcal, F. Croce, S. Depaula, M.A. Rodríguez, H. Cerecetto & M. González. (2009) o-Nitroanilines as major metabolic products of anti-Trypanosoma cruzi 5-phenylethenylbenzofuroxans in microsomal and cytosolic fractions of rat hepatocytes and in whole parasitic cells. Xenobiotica 39:3, pages 236-248.
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A. Messina, V. Chirulli, P. G. Gervasi & V. Longo. (2008) Purification, molecular cloning, heterologous expression and characterization of pig CYP1A2. Xenobiotica 38:12, pages 1453-1470.
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Kesu Dong, Yoshiko Sugita-Konishi, Jing Yu, Phitsanu Tulayakul & Susumu Kumagai. (2008) The effects of subcutaneous administration of T-2 toxin on liver drug metabolizing enzymes in piglets. Toxicological & Environmental Chemistry 90:2, pages 401-413.
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Articles from other publishers (26)

Floriane Lignet, Eva Sherbetjian, Nicole Kratochwil, Russell Jones, Claudia Suenderhauf, Michael B. Otteneder, Thomas Singer & Neil Parrott. (2016) Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach. Pharmaceutical Research 33:10, pages 2565-2579.
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. (2016) Safety and efficacy of secondary alicyclic saturated and unsaturated alcohols, ketones, ketals and esters with ketals containing alicyclic alcohols or ketones and esters containing secondary alicyclic alcohols from chemical group 8 when used as flavourings for all animal species. EFSA Journal 14:6.
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. (2016) Safety and efficacy of eight compounds belonging to chemical group 31 (aliphatic and aromatic hydrocarbons) when used as flavourings for all animal species and categories. EFSA Journal 14:1.
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Xinxin Ding & Fang Xie. 2015. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation 63 92 .
. (2015) Scientific Opinion on the safety and efficacy of aliphatic and aromatic hydrocarbons (chemical group 31) when used as flavourings for all animal species. EFSA Journal 13:3, pages 4053.
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Claudia Suenderhauf & Neil Parrott. (2012) A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation. Pharmaceutical Research 30:1, pages 1-15.
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Hefei Zhang, Thomas E. Prisinzano & Maureen D. Donovan. (2012) Permeation and metabolism of cocaine in the nasal mucosa. European Journal of Drug Metabolism and Pharmacokinetics 37:4, pages 255-262.
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C. Frieke Kuper, Heinrich Ernst, Lidy C. M. van Oostrum, Susanne Rittinghausen, André H. Penninks, Niels-Christian Ganderup & André P. M. Wolterbeek. (2012) Nasal Passages of Göttingen Minipigs from the Neonatal Period to Young Adult. Toxicologic Pathology 40:4, pages 656-666.
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Z.‐Y. LIU, M.‐H. DAI, Y.‐F. TAO, D.‐M. CHEN & Z.‐H. YUAN. (2011) Inhibition of cytochrome P450 2A participating in coumarin 7‐hydroxylation in pig liver microsomes. Journal of Veterinary Pharmacology and Therapeutics 34:5, pages 424-429.
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Gerd Bode, Peter Clausing, Frederic Gervais, Jeanet Loegsted, Jörg Luft, Vicente Nogues & Jennifer Sims. (2010) The utility of the minipig as an animal model in regulatory toxicology. Journal of Pharmacological and Toxicological Methods 62:3, pages 196-220.
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A. Messina, A. Nannelli, R. Fiorio, V. Longo & P.G. Gervasi. (2009) Expression and inducibility of CYP1A1, 1A2, 1B1 by β-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig. Toxicology 260:1-3, pages 47-52.
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Annalisa Nannelli, Vera Chirulli, Vincenzo Longo & P. Giovanni Gervasi. (2008) Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. Toxicology 252:1-3, pages 105-112.
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E. Tydén, L. Olsén, J. Tallkvist, H. Tjälve & P. Larsson. (2008) Cytochrome P450 3A, NADPH cytochrome P450 reductase and cytochrome b5 in the upper airways in horse. Research in Veterinary Science 85:1, pages 80-85.
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Christophe Morisseau & Bruce D Hammock. (2008) Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical. Pest Management Science 64:6, pages 594-609.
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D. Klimmeck, U. Mayer, N. Ungerer, U. Warnken, M. Schnölzer, S. Frings & F. Möhrlen. (2008) Calcium-signaling networks in olfactory receptor neurons. Neuroscience 151:3, pages 901-912.
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Vera Chirulli, Luigi Marvasi, Anna Zaghini, Roberto Fiorio, Vincenzo Longo & P. Giovanni Gervasi. (2007) Inducibility of AhR-regulated CYP genes by β-naphthoflavone in the liver, lung, kidney and heart of the pig. Toxicology 240:1-2, pages 25-37.
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N. Fransén, U. Espefält Westin, C. Nyström & E. Björk. (2007) The in vitro transport of dihydroergotamine across porcine nasal respiratory and olfactory mucosa and the effect of a novel powder formulation. Journal of Drug Delivery Science and Technology 17:4, pages 267-271.
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Karunya K. Kandimalla & Maureen D. Donovan. (2005) Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: Implications on nose‐to‐brain transport. Journal of Pharmaceutical Sciences 94:3, pages 613-624.
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Kim Dalhoff, Kaspar Buus Jensen & Henrik Enghusen Poulsen. 2005. Phase II Conjugation Enzymes and Transport Systems. Phase II Conjugation Enzymes and Transport Systems 618 627 .
Eva Anzenbacherová, Pavel Anzenbacher, Zbyněk Svoboda, Jitka Ulrichová, Jaroslav Květina, Jana Zoulová, František Perlík & Jiřina Martínková. (2003) Minipig as a model for drug metabolism in man: Comparison of in vitro and in vivo metabolism of propafenone. Biomedical Papers 147:2, pages 155-159.
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Michelle Weech, Michelle Quash & Eric Walters. (2003) Characterization of the mouse olfactory glutathione S ‐transferases during the acute phase response . Journal of Neuroscience Research 73:5, pages 679-685.
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Xinxin Ding & Alan Dahl. 2003. Handbook of Olfaction and Gustation. Handbook of Olfaction and Gustation.
O. Dale, R. Hjortkjær & E. D. Kharasch. (2002) Nasal administration of opioids for pain management in adults. Acta Anaesthesiologica Scandinavica 46:7, pages 759-770.
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Karin Östh, Johan Gråsjö & Erik Björk. (2002) A New Method for Drug Transport Studies on Pig Nasal Mucosa Using a Horizontal Ussing Chamber. Journal of Pharmaceutical Sciences 91:5, pages 1259-1273.
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Sandra Marini, Vincenzo Longo, Cinzia Zaccaro, Francesco De Matteis & Pier Giovanni Gervasi. (2001) Selective inactivation of rat and bovine olfactory cytochrome P450 by three haloethanes. Toxicology Letters 124:1-3, pages 83-90.
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M. Giorgi, S. Marini, V. Longo, A. Mazzaccaro, G. Amato & P.G. Gervasi. (2000) Cytochrome P450-Dependent Monooxygenase Activities and Their Inducibility by Classic P450 Inducers in the Liver, Kidney, and Nasal Mucosa of Male Adult Ring-Necked Pheasants. Toxicology and Applied Pharmacology 167:3, pages 237-245.
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