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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 9
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Research Article

Development of a small-scale bioreactor for drug metabolism studies maintaining hepatospecific functions

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Pages 815-825 | Published online: 22 Sep 2008

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Read on this site (3)

Piyun Chao, Annette S Uss & KC Cheng. (2010) Use of intrinsic clearance for prediction of human hepatic clearance. Expert Opinion on Drug Metabolism & Toxicology 6:2, pages 189-198.
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Daniel Palmes, Karim A. Qayumi, Hans-Ullrich Spiegel. (2000) Liver Bridging Techniques in the Treatment of Acute Liver Failure. Journal of Investigative Surgery 13:6, pages 299-311.
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Shyam Sundhar Bale & Jeffrey T. Borenstein. (2018) Microfluidic Cell Culture Platforms to Capture Hepatic Physiology and Complex Cellular Interactions. Drug Metabolism and Disposition 46:11, pages 1638-1646.
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Kyoungju ChoiWilliam P. PfundMelvin E. AndersenRussell S. ThomasHarvey J. ClewellEdward L. LeCluyse. (2014) Development of 3D Dynamic Flow Model of Human Liver and Its Application to Prediction of Metabolic Clearance of 7-Ethoxycoumarin. Tissue Engineering Part C: Methods 20:8, pages 641-651.
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Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner & Stuart Creton. (2013) Novel in vitro and mathematical models for the prediction of chemical toxicity. Toxicol. Res. 2:1, pages 40-59.
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Angela Dudda & Gert Ulrich Kuerzel. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 1053 1094 .
Sanja Pavlica, Stephanie Schmitmeier, Pia Gloeckner, Antonella Piscioneri, Frank Peinemann, Knut Krohn, Michaela Siegmund-Schulz, Stefania Laera, Pietro Favia, Loredana De Bartolo & Augustinus Bader. (2012) Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes. Journal of Tissue Engineering and Regenerative Medicine 6:6, pages 486-496.
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Sanja Pavlica, Javorina Milosevic, Mario Keller, Mattes Schulze, Frank Peinemann, Antonella Piscioneri, Loredana De Bartolo, Kai Darsow, Sebastian Bartel, Harald A. Lange & Augustinus Bader. (2012) Erythropoietin enhances cell proliferation and survival of human fetal neuronal progenitors in normoxia. Brain Research 1452, pages 18-28.
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Carl‐Fredrik Mandenius & Mats Björkman. 2011. Biomechatronic Design in Biotechnology. Biomechatronic Design in Biotechnology 229 247 .
CHUKWUEMEKA ANENE-NZELU, YAN WANG, HANRY YU & LEO HWA LIANG. (2011) LIVER TISSUE MODEL FOR DRUG TOXICITY SCREENING. Journal of Mechanics in Medicine and Biology 11:02, pages 369-390.
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Eric Novik, Timothy J. Maguire, Piyun Chao, K.C. Cheng & Martin L. Yarmush. (2010) A microfluidic hepatic coculture platform for cell-based drug metabolism studies. Biochemical Pharmacology 79:7, pages 1036-1044.
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B. Andria, A. Bracco, G. Cirino & R. A. F. M. Chamuleau. (2010) Liver Cell Culture Devices. Cell Medicine 1:1, pages 55-70.
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Shibashish Giri, Karen Nieber, Ali Acikgöz, Sanja Pavlica, Mario Keller & Augustinus Bader. (2009) Telomerase activity and hepatic functions of rat embryonic liver progenitor cell in nanoscaffold-coated model bioreactor. Molecular and Cellular Biochemistry 336:1-2, pages 137-149.
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Sanja Pavlica, Antonella Piscioneri, Frank Peinemann, Mario Keller, Javorina Milosevic, Andrea Staeudte, Andreas Heilmann, Michaela Schulz-Siegmund, Stefania Laera, Pietro Favia, Loredana De Bartolo & Augustinus Bader. (2009) Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials 30:33, pages 6514-6521.
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P. Chao, T. Maguire, E. Novik, K.-C. Cheng & M.L. Yarmush. (2009) Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human. Biochemical Pharmacology 78:6, pages 625-632.
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Hiroyuki Ijima, Yasuo Kakeya, Takahiro Ogata & Takanori Sakai. (2009) Development of a practical small-scale circulation bioreactor and application to a drug metabolism simulator. Biochemical Engineering Journal 44:2-3, pages 292-296.
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Ali Acikgöz, Najibulla Karim, Shibashish Giri, Wolfgang Schmidt-Heck & Augustinus Bader. (2009) Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. Toxicology and Applied Pharmacology 234:2, pages 179-191.
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ADAM WOOLLEY. 2008. A Guide to Practical Toxicology. A Guide to Practical Toxicology 59 87 .
Randall E. McClelland & Lola M. Reid. 2008. Principles of Regenerative Medicine. Principles of Regenerative Medicine 928 945 .
Stephanie Schmitmeier, Angelika Langsch, Wolfgang Schmidt-Heck, Inka Jasmund & Augustinus Bader. (2007) Improvement of metabolic performance of primary hepatocytes in hyperoxic cultures by vitamin C in a novel small-scale bioreactor. Journal of Membrane Science 298:1-2, pages 30-40.
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I. Jasmund, S. Schwientek, A. Acikgöz, A. Langsch, H.G. Machens & A. Bader. (2007) The influence of medium composition and matrix on long-term cultivation of primary porcine and human hepatocytes. Biomolecular Engineering 24:1, pages 59-69.
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Stephanie Schmitmeier, Angelika Langsch, Inka Jasmund & Augustinus Bader. (2006) Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings. Biotechnology and Bioengineering 95:6, pages 1198-1206.
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Stephanie Schmitmeier, Angelika Langsch & Augustinus Bader. (2006) A membrane-based small-scale bioreactor for accelerated in vitro drug screenings with primary hepatocytes. Desalination 199:1-3, pages 258-260.
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Enrico Drioli & Loredana De Bartolo. (2006) Membrane Bioreactor for Cell Tissues and Organoids. Artificial Organs 30:10, pages 793-802.
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Loredana De Bartolo, Simona Salerno, Lidietta Giorno, Sabrina Morelli, Giuseppe Barbieri, Efrem Curcio, Maria Rende & Enrico Drioli. (2006) Membrane bioreactor using pig hepatocytes for in vitro evaluation of anti-inflammatory drugs. Catalysis Today 118:1-2, pages 172-180.
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Loredana De Bartolo, Simona Salerno, Sabrina Morelli, Lidietta Giorno, Maria Rende, Bruno Memoli, Alfredo Procino, Vittorio E. Andreucci, Augustinus Bader & Enrico Drioli. (2006) Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor. Biomaterials 27:27, pages 4794-4803.
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Xiaoyue Zhu, Tommaso Bersano‐Begey, Yoko Kamotani & Shuichi Takayama. 2006. Encyclopedia of Medical Devices and Instrumentation. Encyclopedia of Medical Devices and Instrumentation.
Sonja Diekmann, Augustinus Bader & Stephanie Schmitmeier. (2006) Present and Future Developments in Hepatic Tissue Engineering for Liver Support Systems. Cytotechnology 50:1-3, pages 163-179.
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Angela Dudda & Gert Ulrich Kürzel. 2006. Drug Discovery and Evaluation. Drug Discovery and Evaluation 493 520 .
Dora Farkas & Steven R. Tannenbaum. (2005) Characterization of Chemically Induced Hepatotoxicity in Collagen Sandwiches of Rat Hepatocytes. Toxicological Sciences 85:2, pages 927-934.
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Nikolina Canová, Eva Kmoníčková, Dagmar Lincová, Libor Vítek & Hassan Farghali. (2019) Evaluation of a Flat Membrane Hepatocyte Bioreactor for Pharmacotoxicological Applications: Evidence that Inhibition of Spontaneously Produced Nitric Oxide Improves Cell Functionality. Alternatives to Laboratory Animals 32:1, pages 25-35.
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Adam Woolley. 2003. A Guide to Practical Toxicology. A Guide to Practical Toxicology 304 310 .
L. Giorno, L. De Bartolo & E. Drioli. 2003. New Insights into Membrane Science and Technology: Polymeric and Biofunctional Membranes. New Insights into Membrane Science and Technology: Polymeric and Biofunctional Membranes 187 217 .
Mark J. Powers, Dena M. Janigian, Kathryn E. Wack, Carolyn S. Baker, Donna Beer Stolz & Linda G. Griffith. (2002) Functional Behavior of Primary Rat Liver Cells in a Three-Dimensional Perfused Microarray Bioreactor. Tissue Engineering 8:3, pages 499-513.
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L. De Bartolo & A. Bader. (2009) Development of a hybrid liver-support device. Minimally Invasive Therapy & Allied Technologies 11:3, pages 123-134.
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L. Bartolo & A. Bader. 2002. Stem Cell Transplantation and Tissue Engineering. Stem Cell Transplantation and Tissue Engineering 89 104 .
Angelika Langsch & Augustinus Bader. (2001) Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors. Biotechnology and Bioengineering 76:2, pages 115-125.
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T.B. Darr & A. Hubel. (2001) Postthaw Viability of Precultured Hepatocytes. Cryobiology 42:1, pages 11-20.
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Augustinus Bader, Loredana De Bartolo & Axel Haverich. (2000) High level benzodiazepine and ammonia clearance by flat membrane bioreactors with porcine liver cells. Journal of Biotechnology 81:2-3, pages 95-105.
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L. De Bartolo, G. Jarosch‐Von Schweder, A. Haverich & A. Bader. (2008) A Novel Full‐Scale Flat Membrane Bioreactor Utilizing Porcine Hepatocytes: Cell Viability and Tissue‐Specific Functions. Biotechnology Progress 16:1, pages 102-108.
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Augustinus Bader, Erich Knop & Axel Haverich. 2000. The Hepatocyte Review. The Hepatocyte Review 97 115 .
Loredana De Bartolo & Augustinus Bader. 2000. The Hepatocyte Review. The Hepatocyte Review 585 595 .

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