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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 9
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Research Article

In vitro toxicity of zamifenacin (UK-76,654) and metabolites in primary hepatocyte cultures

D. E. AMACHER Drug Safety Evaluation, Pfizer Central Research, Groton, CT 06340, USA OE Pfizer Centre de Recherche, Amboise, France Department of Drug Metabolism, Pfizer Central Research, Sandwich, UK
,
L. M. FASULO Drug Safety Evaluation, Pfizer Central Research, Groton, CT 06340, USA OE Pfizer Centre de Recherche, Amboise, France Department of Drug Metabolism, Pfizer Central Research, Sandwich, UK
,
C. CHARUEL Drug Safety Evaluation, Pfizer Central Research, Groton, CT 06340, USA OE Pfizer Centre de Recherche, Amboise, France Department of Drug Metabolism, Pfizer Central Research, Sandwich, UK
,
P. COMBY Drug Safety Evaluation, Pfizer Central Research, Groton, CT 06340, USA OE Pfizer Centre de Recherche, Amboise, France Department of Drug Metabolism, Pfizer Central Research, Sandwich, UK
&
K. BEAUMONT Drug Safety Evaluation, Pfizer Central Research, Groton, CT 06340, USA OE Pfizer Centre de Recherche, Amboise, France Department of Drug Metabolism, Pfizer Central Research, Sandwich, UK
Pages 895-908 | Published online: 22 Sep 2008

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Zhong-Ze Fang, Yan-Yan Zhang, Xiu-Li Wang, Yun-Feng Cao, Hong Huo & Ling Yang. (2011) Bioactivation of herbal constituents: simple alerts in the complex system. Expert Opinion on Drug Metabolism & Toxicology 7:8, pages 989-1007.
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Amit S Kalgutkar & John R Soglia. (2005) Minimising the potential for metabolic activation in drug discovery. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 91-142.
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Articles from other publishers (9)

Donald J. AbrahamBryan Norman. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 28 .
Magda Sachana & Alan J. Hargreaves. 2018. Veterinary Toxicology. Veterinary Toxicology 145 161 .
Elisabet Berggren, Andrew White, Gladys Ouedraogo, Alicia Paini, Andrea-Nicole Richarz, Frederic Y. Bois, Thomas Exner, Sofia Leite, Leo A. van Grunsven, Andrew Worth & Catherine Mahony. (2017) Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods. Computational Toxicology 4, pages 31-44.
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Pasan Fernando, Xuxu Yan, Julia Lockwood, Yin Duan, Lihui Wei, R. Glenn Wells, Corinne Bensimon, Wayne M. Mullett & Terrence Ruddy. (2014) Toxicological Evaluation of a Rotenone Derivative in Rodents for Clinical Myocardial Perfusion Imaging. Cardiovascular Toxicology 14:2, pages 170-182.
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Magda Sachana & Alan J. Hargreaves. 2012. Veterinary Toxicology. Veterinary Toxicology 62 79 .
Donald J. AbrahamJulian Blagg. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 301 334 .
Magda Sachana & Alan J. Hargreaves. 2007. Veterinary Toxicology. Veterinary Toxicology 51 66 .
C.J. Deglmann, R. Metzger, M. Stickel, S. Hoerrlein, F.W. Schildberg & H.G. Koebe. (2018) A New Bioassay Including a Small Scale Hepatocyte Bioreactor for Hepato-Mediated Toxicity Testing in a Target Cell Line. The International Journal of Artificial Organs 25:10, pages 975-984.
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K. Latonnelle, F. Le Menn, S.J. Kaushik & C. Bennetau-Pelissero. (2002) Effects of Dietary Phytoestrogens in Vivo and in Vitro in Rainbow Trout and Siberian Sturgeon: Interests and Limits of the in Vitro Studies of Interspecies Differences. General and Comparative Endocrinology 126:1, pages 39-51.
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