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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 8
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Research Article

Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo

E. TANAKA Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
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C. NARISAWA Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
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H. NAKAMURA Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
,
Y. SAWA Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
,
H. ETOH Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
,
K. TADANO Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
,
T. HORIE Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
,
H. OHKAWA Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
&
S. MISAWA Institute of Community Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan Eisai Research Laboratories, Eisai Co., Ltd, Ibaraki-ken 300-2635, Japan
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Pages 795-802 | Published online: 22 Sep 2008

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Leposava Antonovic & Marilyn Martinez. (2011) Role of the Cytochrome P450 Enzyme System in Veterinary Pharmacokinetics: Where are We Now? Where are We Going?. Future Medicinal Chemistry 3:7, pages 855-879.
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M. J. Graham, A. R. Bell, H. K. Crewe, C. L. Moorcraft, L. Walker, E. F. Whittaker & M. S. Lennard. (2003) mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates. Xenobiotica 33:3, pages 225-237.
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B. D. van Groen, J. Nicolaï, A. C. Kuik, S. Van Cruchten, E. van Peer, A. Smits, S. Schmidt, S. N. de Wildt, K. Allegaert, L. De Schaepdrijver, P. Annaert & J. Badée. (2021) Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species. Pharmacological Reviews 73:2, pages 597-678.
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M. D. Pairis‐Garcia, A. K. Johnson, B. KuKanich, L. Wulf, S. T. Millman, K. J. Stalder, L. A. Karriker & J. F. Coetzee. (2014) Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration. Journal of Veterinary Pharmacology and Therapeutics 38:3, pages 265-270.
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Peter Mansell, Keith Robinson, Daniel Minck, Mark E. Hurtt & Gregg D. Cappon. (2011) Toxicology and toxicokinetics of oral pantoprazole in neonatal and juvenile dogs. Birth Defects Research Part B: Developmental and Reproductive Toxicology, pages n/a-n/a.
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Beth Miskimins Mills, Matthew J. Zaya, Rodney R. Walters, Kenneth L. Feenstra, Julie A. White, Jason Gagne & Charles W. Locuson. (2010) Current Cytochrome P450 Phenotyping Methods Applied to Metabolic Drug-Drug Interaction Prediction in Dogs. Drug Metabolism and Disposition 38:3, pages 396-404.
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Jonathan Verreault, France Maisonneuve, Rune Dietz, Christian Sonne & Robert J. Letcher. (2009) Comparative hepatic activity of xenobiotic‐metabolizing enzymes and concentrations of organohalogens and their hydroxylated analogues in captive greenland sledge dogs ( Canis familiaris ) . Environmental Toxicology and Chemistry 28:1, pages 162-172.
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Masashi Mise, Takanori Hashizume & Setsuko Komuro. (2008) Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes. Drug Metabolism and Disposition 36:9, pages 1903-1908.
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Johanna Fink-Gremmels. (2008) Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences. European Journal of Pharmacology 585:2-3, pages 502-509.
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Jay Tibbitts. (2016) Issues Related to the Use of Canines in Toxicologic Pathology—Issues With Pharmacokinetics and Metabolism. Toxicologic Pathology 31:1_suppl, pages 17-24.
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Zoheir A Damanhouri. (2002) Mixed function oxidases in kidney and duodenum of camel, guinea pig and rat. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 132:4, pages 445-450.
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K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food and Chemical Toxicology 39:7, pages 667-680.
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