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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 7
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Research Article

Physiological factors affecting protein expression of flavin-containing monooxygenases 1, 3 and 5

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Pages 673-682 | Published online: 22 Sep 2008

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Yildiz Yilmaz, Gareth Williams, Nenad Manevski, Markus Walles, Stephan Krähenbühl & Gian Camenisch. (2019) Functional assessment of rat pulmonary flavin-containing monooxygenase activity. Xenobiotica 49:5, pages 503-512.
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Ian R. Phillips & Elizabeth A. Shephard. (2017) Drug metabolism by flavin-containing monooxygenases of human and mouse. Expert Opinion on Drug Metabolism & Toxicology 13:2, pages 167-181.
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Elizabeth A Shephard & Ian R Phillips. (2010) The potential of knockout mouse lines in defining the role of flavin-containing monooxygenases in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 6:9, pages 1083-1094.
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R.C.A. Onderwater, A.E. Rettie, J.N.M. Commandeur & N.P.E. Vermeulen. (2006) Bioactivation of N-substituted N′-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3. Xenobiotica 36:7, pages 645-657.
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Ronald N Hines. (2006) Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3. Expert Opinion on Drug Metabolism & Toxicology 2:1, pages 41-49.
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Klaudia M. Maksymiuk, Mateusz Szudzik, Emilia Samborowska, Dawid Chabowski, Marek Konop & Marcin Ufnal. (2024) Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases. PLOS ONE 19:1, pages e0297474.
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Teruo Miyazaki. (2024) Identification of a novel enzyme and the regulation of key enzymes in mammalian taurine synthesis. Journal of Pharmacological Sciences 154:1, pages 9-17.
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Ian R. Phillips, Sunil Veeravalli, Sanjay Khadayate & Elizabeth A. Shephard. (2023) Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism. PLOS ONE 18:6, pages e0286692.
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Shijiao Huang, Marshall B. Howington, Craig J. Dobry, Charles R. Evans & Scott F. Leiser. (2021) Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism. Frontiers in Cell and Developmental Biology 9.
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Zhu‐Lin Yu, Ling‐Yu Zhang, Xiao‐Ming Jiang, Chang‐Hu Xue, Naiqiu Chi, Tian‐Tian Zhang & Yu‐Ming Wang. (2020) Effects of dietary choline, betaine, and L‐carnitine on the generation of trimethylamine‐N‐oxide in healthy mice. Journal of Food Science 85:7, pages 2207-2215.
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H. Eng, R. Sharma, A. Wolford, L. Di, R. B. Ruggeri, L. Buckbinder, E. L. Conn, D. K. Dalvie & A. S. Kalgutkar. (2016) Species Differences in the Oxidative Desulfurization of a Thiouracil-Based Irreversible Myeloperoxidase Inactivator by Flavin-Containing Monooxygenase Enzymes. Drug Metabolism and Disposition 44:8, pages 1262-1269.
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Jamie Lee, Stephenie D. Prokopec, John D. Watson, Ren X. Sun, Raimo Pohjanvirta & Paul C. Boutros. (2015) Male and female mice show significant differences in hepatic transcriptomic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BMC Genomics 16:1.
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Swetha Rudraiah, Philip R. Rohrer, Igor Gurevich, Michael J. Goedken, Theodore Rasmussen, Ronald N. Hines & José E. Manautou. (2014) Tolerance to Acetaminophen Hepatotoxicity in the Mouse Model of Autoprotection Is Associated with Induction of Flavin-Containing Monooxygenase-3 (FMO3) in Hepatocytes. Toxicological Sciences 141:1, pages 263-277.
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Jamie Moscovitz & Lauren Aleksunes. (2013) Establishment of Metabolism and Transport Pathways in the Rodent and Human Fetal Liver. International Journal of Molecular Sciences 14:12, pages 23801-23827.
Crossref
Lai Peng, Julia Y. Cui, Byunggil Yoo, Sumedha S. Gunewardena, Hong Lu, Curtis D. Klaassen & Xiao-bo Zhong. (2013) RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice. Drug Metabolism and Disposition 41:12, pages 2175-2186.
Crossref
Alexander V. LyubimovAndrew Bessire, Kuresh Youdim, Susan Hurst & Caroline A. Lee. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 88 .
Meike S. Motika, Jun Zhang, Erik C. Ralph, Mary A. Dwyer & John R. Cashman. (2012) pH dependence on functional activity of human and mouse flavin-containing monooxygenase 5. Biochemical Pharmacology 83:7, pages 962-968.
Crossref
Alexander V. LyubimovMatthew J. Hutzler & Matthew A. Cerny. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 40 .
Edward Croom. 2012. Toxicology and Human Environments. Toxicology and Human Environments 31 88 .
Ernest Hodgson. 2012. Pesticide Biotransformation and Disposition. Pesticide Biotransformation and Disposition 73 116 .
Ernest Hodgson. 2012. Pesticide Biotransformation and Disposition. Pesticide Biotransformation and Disposition 53 72 .
DaCheng Hao & PeiGen Xiao. (2011) Prediction of sites under adaptive evolution in flavin-containing monooxygenases: Selection pattern revisited. Chinese Science Bulletin 56:12, pages 1246-1255.
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Hana Bártíková, Veronika Křížová, Martina Štěpničková, Jiří Lamka, Vladimír Kubíček, Lenka Skálová & Barbora Szotáková. (2010) Activities of biotransformation enzymes and flubendazole metabolism in lambs (Ovis aries): effect of gender and flubendazole therapy. Pharmacological Reports 62:2, pages 362-373.
Crossref
Ernest Hodgson. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 893 921 .
Ernest Hodgson. 2010. Hayes' Handbook of Pesticide Toxicology. Hayes' Handbook of Pesticide Toxicology 865 875 .
Da Cheng Hao, Shi Lin Chen, Jun Mu & Pei Gen Xiao. (2009) Molecular phylogeny, long-term evolution, and functional divergence of flavin-containing monooxygenases. Genetica 137:2, pages 173-187.
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Gabriela Rodríguez-Fuentes, Cary Coburn, Margarita Currás-Collazo, Gabriel Guillén & Daniel Schlenk. (2009) Effect of hyperosmotic conditions on flavin-containing monooxygenase activity, protein and mRNA expression in rat kidney. Toxicology Letters 187:2, pages 115-118.
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Raymond Kemper, Johnnie Hayes & Matthew Bogdanffy. 2007. Principles and Methods of Toxicology, Fifth Edition. Principles and Methods of Toxicology, Fifth Edition 103 178 .
Elizabeth A. ShephardPritpal ChandanMilena Stevanovic-WalkerMina EdwardsIan R. Phillips. (2007) Alternative promoters and repetitive DNA elements define the species-dependent tissue-specific expression of the FMO1 genes of human and mouse . Biochemical Journal 406:3, pages 491-499.
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Jun Zhang, Matt A. Cerny, Matt Lawson, Ruzbeh Mosadeghi & John R. Cashman. (2007) Functional activity of the mouse flavin‐containing monooxygenase forms 1, 3, and 5. Journal of Biochemical and Molecular Toxicology 21:4, pages 206-215.
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Sevasti B. Koukouritaki, Mark T. Poch, Marilyn C. Henderson, Lisbeth K. Siddens, Sharon K. Krueger, Jonathan E. VanDyke, David E. Williams, Nicholas M. Pajewski, Tao Wang & Ronald N. Hines. (2007) Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants. Journal of Pharmacology and Experimental Therapeutics 320:1, pages 266-273.
Crossref
Ronald Hines. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 11 .
W. H. Boylston, James H. DeFord & John Papaconstantinou. (2006) Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. AGE 28:2, pages 125-144.
Crossref
Jun Zhang & John R. Cashman. (2006) QUANTITATIVE ANALYSIS OF FMO GENE mRNA LEVELS IN HUMAN TISSUES . Drug Metabolism and Disposition 34:1, pages 19-26.
Crossref
Azara Janmohamed, Diana Hernandez, Ian R Phillips & Elizabeth A Shephard. (2004) Cell-, tissue-, sex- and developmental stage-specific expression of mouse flavin-containing monooxygenases (Fmos). Biochemical Pharmacology 68:1, pages 73-83.
Crossref
G. Virkel, A. Lifschitz, J. Sallovitz, A. Pis & C. Lanusse. (2004) COMPARATIVE HEPATIC AND EXTRAHEPATIC ENANTIOSELECTIVE SULFOXIDATION OF ALBENDAZOLE AND FENBENDAZOLE IN SHEEP AND CATTLE. Drug Metabolism and Disposition 32:5, pages 536-544.
Crossref
Khawja A. Usmani, Edward D. Karoly, Ernest Hodgson & Randy L. Rose. (2004) IN VITRO SULFOXIDATION OF THIOETHER COMPOUNDS BY HUMAN CYTOCHROME P450 AND FLAVIN-CONTAINING MONOOXYGENASE ISOFORMS WITH PARTICULAR REFERENCE TO THE CYP2C SUBFAMILY. Drug Metabolism and Disposition 32:3, pages 333-339.
Crossref
Dieter Lang & Amit Kalgutkar. 2003. Drug Metabolizing Enzymes. Drug Metabolizing Enzymes 483 539 .
Randy L. Rose. (2002) Measurements of Flavin‐Containing Monooxygenase ( FMO ) Activities . Current Protocols in Toxicology 13:1.
Crossref
Virginie Lattard, Joel Lachuer, Thierry Buronfosse, François Garnier & Etienne Benoit. (2002) Physiological factors affecting the expression of FMO1 and FMO3 in the rat liver and kidney. Biochemical Pharmacology 63:8, pages 1453-1464.
Crossref
Shelley A. Larsen-Su, Sharon K. Krueger, Mei-Fei Yueh, Clifford B. Pereira & David E. Williams. (2002) Developmental regulation of flavin-containing monooxygenase form 1 in the liver and kidney of fetal and neonatal rabbits. Biochemical Pharmacology 63:7, pages 1353-1359.
Crossref
Uday Bandyopadhyay, Kausik Biswas & Ranajit K. Banerjee. (2002) Extrathyroidal actions of antithyroid thionamides. Toxicology Letters 128:1-3, pages 117-127.
Crossref
Sevasti B Koukouritaki, Pippa Simpson, Catherine K Yeung, Allan E Rettie & Ronald N Hines. (2002) Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression. Pediatric Research 51:2, pages 236-243.
Crossref
S. Katchamart & D.E. Williams. (2001) Indole-3-carbinol modulation of hepatic monooxygenases CYP1A1, CYP1A2 and FMO1 in guinea pig, mouse and rabbit. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 129:4, pages 377-384.
Crossref
Virginie Lattard, Thierry Buronfosse, Joel Lachuer, Christiane Longin-Sauvageon, Colette Moulin & Etienne Benoit. (2001) Cloning, Sequencing, Tissue Distribution, and Heterologous Expression of Rat Flavin-Containing Monooxygenase 3. Archives of Biochemistry and Biophysics 391:1, pages 30-40.
Crossref
Ernest Hodgson & E. Levi Patricia. 2001. Handbook of Pesticide Toxicology. Handbook of Pesticide Toxicology 531 562 .
Ernest Hodgson, Nathan J. Cherrington, Richard M. Philpot & Randy L. Rose. 1999. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes 55 70 .

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