Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 5
Submit an article Journal homepage
189
Views
53
CrossRef citations to date
0
Altmetric
Research Article

Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines

A. LAMPEN Institut for Lebensmitteltoxikologie, Tiera $ rztliche Hochschule Hannover, Germany OE Leibniz Laboratories of Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany Department of Surgery, Medizinische Hochschule Hannover, Germany Organische Chemie, Technische Universita Braunschweig, Germany
,
A. BADER Institut for Lebensmitteltoxikologie, Tiera $ rztliche Hochschule Hannover, Germany OE Leibniz Laboratories of Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany Department of Surgery, Medizinische Hochschule Hannover, Germany Organische Chemie, Technische Universita Braunschweig, Germany
,
T. BESTMANN Institut for Lebensmitteltoxikologie, Tiera $ rztliche Hochschule Hannover, Germany OE Leibniz Laboratories of Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany Department of Surgery, Medizinische Hochschule Hannover, Germany Organische Chemie, Technische Universita Braunschweig, Germany
,
M. WINKLER Institut for Lebensmitteltoxikologie, Tiera $ rztliche Hochschule Hannover, Germany OE Leibniz Laboratories of Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany Department of Surgery, Medizinische Hochschule Hannover, Germany Organische Chemie, Technische Universita Braunschweig, Germany
,
L. WITTE Institut for Lebensmitteltoxikologie, Tiera $ rztliche Hochschule Hannover, Germany OE Leibniz Laboratories of Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany Department of Surgery, Medizinische Hochschule Hannover, Germany Organische Chemie, Technische Universita Braunschweig, Germany
&
J. T. BORLAK* Institut for Lebensmitteltoxikologie, Tiera $ rztliche Hochschule Hannover, Germany OE Leibniz Laboratories of Biotechnology and Artificial Organs, Medizinische Hochschule Hannover, Germany Department of Surgery, Medizinische Hochschule Hannover, Germany Organische Chemie, Technische Universita Braunschweig, Germany
Pages 429-441 | Published online: 22 Sep 2008

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Seung Hwan Lee, Nakwon Choi & Jong Hwan Sung. (2019) Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models. Expert Opinion on Drug Metabolism & Toxicology 15:12, pages 1005-1019.
Read now
Ruonan Chen, Lan Li, Chenlin Shen, Cheng Huang, Taotao Ma, Xiaoming Meng, Zhengyue Qian, Yangyang Li & Jun Li. (2017) Intestinal transport of HDND-7, a novel hesperetin derivative, in in vitro MDCK cell and in situ single-pass intestinal perfusion models. Xenobiotica 47:8, pages 719-730.
Read now
DeacqunitaL. Diggs, AshleyC. Huderson, KellyL. Harris, JeremyN. Myers, LeahD. Banks, PerumallaV. Rekhadevi, MohammadS. Niaz & Aramandla Ramesh. (2011) Polycyclic Aromatic Hydrocarbons and Digestive Tract Cancers: A Perspective. Journal of Environmental Science and Health, Part C 29:4, pages 324-357.
Read now
L. Ribonnet, E. van der Heiden, I. Nobels, A. Chaumont, A.-S. Remacle, S. De Saeger, Y.-J. Schneider, M.-L. Scippo, R. Blust, L. Pussemier & Y. Larondelle. (2011) Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants. Food Additives & Contaminants: Part A 28:9, pages 1136-1158.
Read now
Huadong Sun, Edwin CY Chow, Shanjun Liu, Yimin Du & K Sandy Pang. (2008) The Caco-2 cell monolayer: usefulness and limitations. Expert Opinion on Drug Metabolism & Toxicology 4:4, pages 395-411.
Read now
Séverine Cavret, Guido Rychen & Cyril Feidt. (2004) IN VITRO INTESTINAL TRANSFER AND METABOLISM OF POLYCYCLIC AROMATIC HYDROCARBONS. Polycyclic Aromatic Compounds 24:4-5, pages 513-525.
Read now
J. Borlak & C. Zwadlo. (2003) Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells. Xenobiotica 33:9, pages 927-943.
Read now

Articles from other publishers (46)

Kaustubh Kulkarni, Lu Wang & Ming Hu. 2023. Oral Bioavailability and Drug Delivery. Oral Bioavailability and Drug Delivery 715 728 .
Yanping He, Don Hashan Kevin Ketagoda, Richard Bright, Susan Marie Britza, Joshua Zechner, Ian Musgrave, Krasimir Vasilev & Peter Zilm. (2023) Synthesis of Cationic Silver Nanoparticles with Highly Potent Properties against Oral Pathogens and Their Biofilms. ChemNanoMat 9:3.
Crossref
Jeremy N. Myers, Kelly L. Harris, Perumalla V. Rekhadevi, Siddharth Pratap & Aramandla Ramesh. (2021) Benzo(a)pyrene-induced cytotoxicity, cell proliferation, DNA damage, and altered gene expression profiles in HT-29 human colon cancer cells. Cell Biology and Toxicology 37:6, pages 891-913.
Crossref
Bokyeong Ryu, Mi-Young Son, Kwang Bo Jung, Ukjin Kim, Jin Kim, Ohman Kwon, Ye Seul Son, Cho-Rok Jung, Jae-Hak Park & C-Yoon Kim. (2021) Next-Generation Intestinal Toxicity Model of Human Embryonic Stem Cell-Derived Enterocyte-Like Cells. Frontiers in Veterinary Science 8.
Crossref
Van Nguyen Tran, Jitka Viktorová & Tomáš Ruml. (2020) Mycotoxins: Biotransformation and Bioavailability Assessment Using Caco-2 Cell Monolayer. Toxins 12:10, pages 628.
Crossref
Stefan de Gelder, Henrik Sundh, Thamar N.M. Pelgrim, Josef D. Rasinger, Lotte van Daal, Gert Flik, Marc H.G. Berntssen & Peter H.M. Klaren. (2018) Transepithelial transfer of phenanthrene, but not of benzo[ a ]pyrene, is inhibited by fatty acids in the proximal intestine of rainbow trout ( Oncorhynchus mykiss ). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 204, pages 97-105.
Crossref
Laurie Laloux, Madeleine Polet & Yves‐Jacques Schneider. 2017. Nanotechnology in Agriculture and Food Science. Nanotechnology in Agriculture and Food Science 311 332 .
Niloufar Marsousi, Fabienne Doffey‐Lazeyras, Serge Rudaz, Jules A. Desmeules & Youssef Daali. (2016) Intestinal permeability and P‐glycoprotein‐mediated efflux transport of ticagrelor in Caco‐2 monolayer cells. Fundamental & Clinical Pharmacology 30:6, pages 577-584.
Crossref
Jenni Küblbeck, Jenni J. Hakkarainen, Aleksanteri Petsalo, Kati-Sisko Vellonen, Ari Tolonen, Petri Reponen, Markus M. Forsberg & Paavo Honkakoski. (2016) Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity. Journal of Pharmaceutical Sciences 105:2, pages 941-949.
Crossref
Ke Yuan, Haining Kang, Zhenfeng Yue, Lihua Yang, Li Lin, Xiaowei Wang & Tiangang Luan. (2015) Determination of 13 endocrine disrupting chemicals in sediments by gas chromatography–mass spectrometry using subcritical water extraction coupled with dispersed liquid–liquid microextraction and derivatization. Analytica Chimica Acta 866, pages 41-47.
Crossref
Benjamin Wuyts, Danny Riethorst, Joachim Brouwers, Jan Tack, Pieter Annaert & Patrick Augustijns. (2015) Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability. International Journal of Pharmaceutics 478:2, pages 736-744.
Crossref
Anke Ehlers, Anja These, Stefanie Hessel, Angelika Preiss-Weigert & Alfonso Lampen. (2014) Active elimination of the marine biotoxin okadaic acid by P-glycoprotein through an in vitro gastrointestinal barrier. Toxicology Letters 225:2, pages 311-317.
Crossref
Stefanie Hessel, Alfonso Lampen & Albrecht Seidel. (2013) Polycyclic aromatic hydrocarbons in food – Efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells. Food and Chemical Toxicology 62, pages 797-804.
Crossref
Kamila Balusikova & Jan Kovar. (2013) Alcohol dehydrogenase and cytochrome P450 2E1 can be induced by long-term exposure to ethanol in cultured liver HEP-G2 cells. In Vitro Cellular & Developmental Biology - Animal 49:8, pages 619-625.
Crossref
L. Le Hegarat, S. Huet & V. Fessard. (2012) A co-culture system of human intestinal Caco-2 cells and lymphoblastoid TK6 cells for investigating the genotoxicity of oral compounds. Mutagenesis 27:6, pages 631-636.
Crossref
Imme Lengler, Thorsten Buhrke, Eileen Scharmach & Alfonso Lampen. (2012) In‐Vitro Toxicological and Proteomic Analysis of Furan Fatty Acids Which are Oxidative Metabolites of Conjugated Linoleic Acids. Lipids 47:11, pages 1085-1097.
Crossref
E. Theodoratou, Z. Montazeri, S. Hawken, G. C. Allum, J. Gong, V. Tait, I. Kirac, M. Tazari, S. M. Farrington, A. Demarsh, L. Zgaga, D. Landry, H. E. Benson, S. H. Read, I. Rudan, A. Tenesa, M. G. Dunlop, H. Campbell & J. Little. (2012) Systematic Meta-Analyses and Field Synopsis of Genetic Association Studies in Colorectal Cancer. JNCI Journal of the National Cancer Institute 104:19, pages 1433-1457.
Crossref
Linda Böhmert, Birgit Niemann, Andreas F. Thünemann & Alfonso Lampen. (2012) Cytotoxicity of peptide-coated silver nanoparticles on the human intestinal cell line Caco-2. Archives of Toxicology 86:7, pages 1107-1115.
Crossref
Christian KöllnStephan Reichl. (2012) mRNA Expression of Metabolic Enzymes in Human Cornea, Corneal Cell Lines, and Hemicornea Constructs. Journal of Ocular Pharmacology and Therapeutics 28:3, pages 271-277.
Crossref
Thorsten Buhrke, Roswitha Merkel, Imme Lengler & Alfonso Lampen. (2012) Absorption and Metabolism of cis ‐9, trans ‐11‐CLA and of Its Oxidation Product 9,11‐Furan Fatty Acid by Caco‐2 Cells . Lipids 47:4, pages 435-442.
Crossref
M.B. EschT.L. King & M.L. Shuler. (2011) The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies. Annual Review of Biomedical Engineering 13:1, pages 55-72.
Crossref
Kaustubh Kulkarni & Ming Hu. 2011. Oral Bioavailability. Oral Bioavailability 431 442 .
Patrick Knappe, Linda Boehmert, Ralf Bienert, Silvana Karmutzki, Birgit Niemann, Alfonso Lampen & Andreas F. Thünemann. (2011) Processing nanoparticles with A4F-SAXS for toxicological studies: Iron oxide in cell-based assays. Journal of Chromatography A 1218:27, pages 4160-4166.
Crossref
L. Ribonnet, A. Callebaut, I. Nobels, M.-L. Scippo, Y.-J. Schneider, S. De Saeger, L. Pussemier & Y. Larondelle. (2011) Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells. Toxicology Letters 202:3, pages 193-202.
Crossref
Anke Ehlers, Jana Scholz, Anja These, Stefanie Hessel, Angelika Preiss-Weigert & Alfonso Lampen. (2011) Analysis of the passage of the marine biotoxin okadaic acid through an in vitro human gut barrier. Toxicology 279:1-3, pages 196-202.
Crossref
Frank Lehner, Ulf Kulik, Juergen Klempnauer & Juergen Borlak. (2010) Inhibition of the Liver Enriched Protein FOXA2 Recovers HNF6 Activity in Human Colon Carcinoma and Liver Hepatoma Cells. PLoS ONE 5:10, pages e13344.
Crossref
Mika Hamada, Hideo Satsu, Hitoshi Ashida, Yoshiko Sugita-Konishi & Makoto Shimizu. (2010) Metabolites of Galangin by 2,3,7,8-Tetrachlorodibenzo- p -dioxin-Inducible Cytochrome P450 1A1 in Human Intestinal Epithelial Caco-2 Cells and Their Antagonistic Activity toward Aryl Hydrocarbon Receptor . Journal of Agricultural and Food Chemistry 58:13, pages 8111-8118.
Crossref
Gretchen J. Mahler, Mandy B. Esch, Raymond P. Glahn & Michael L. Shuler. (2009) Characterization of a gastrointestinal tract microscale cell culture analog used to predict drug toxicity. Biotechnology and Bioengineering 104:1, pages 193-205.
Crossref
Bernadette Videmann, Michelle Mazallon, Jonathan Tep & Sylvaine Lecoeur. (2008) Metabolism and transfer of the mycotoxin zearalenone in human intestinal Caco-2 cells. Food and Chemical Toxicology 46:10, pages 3279-3286.
Crossref
Bettina Zödl, Diethart Schmid, Georg Wassler, Claudia Gundacker, Valentin Leibetseder, Theresia Thalhammer & Cem Ekmekcioglu. (2007) Intestinal transport and metabolism of acrylamide. Toxicology 232:1-2, pages 99-108.
Crossref
Femke M. van de Water, Johanna M. Boleij, Janny G.P. Peters, Frans G.M. Russel & Rosalinde Masereeuw. (2007) Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines. European Journal of Pharmaceutical Sciences 30:1, pages 36-44.
Crossref
Timo Korjamo, Jukka Mönkkönen, Jouko Uusitalo, Miia Turpeinen, Olavi Pelkonen & Paavo Honkakoski. (2006) Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors. Pharmaceutical Research 23:9, pages 1991-2001.
Crossref
LJ. Glavaš-Obrovac, T. Opačak, V. Bareš, D. Šubarić, J. Babić, V. Ilakovac & I. Karner. (2006) Effects of dealcoholized red and white wines on human tumour and normal cells proliferation. Acta Alimentaria 35:2, pages 153-162.
Crossref
Flavia Zucco, Anne-Françoise Batto, Giovanna Bises, Jean Chambaz, Arianna Chiusolo, Rosa Consalvo, Heide Cross, Gianni Dal Negro, Isabella de Angelis, Gérard Fabre, François Guillou, Sebastian Hoffman, Loïc Laplanche, Etienne Morel, Martine Pinçon-Raymond, Pilar Prieto, Laura Turco, Giulia Ranaldi, Monique Rousset, Yula Sambuy, Maria Laura Scarino, François Torreilles & Annalaura Stammati. (2019) An Inter-laboratory Study to Evaluate the Effects of Medium Composition on the Differentiation and Barrier Function of Caco-2 Cell Lines. Alternatives to Laboratory Animals 33:6, pages 603-618.
Crossref
Slavica Kvolik, Ljubica Glavas-Obrovac, Vesna Bares & Ivan Karner. (2005) Effects of inhalation anesthetics halothane, sevoflurane, and isoflurane on human cell lines. Life Sciences 77:19, pages 2369-2383.
Crossref
A. Lampen, M. Leifheit, J. Voss & H. Nau. (2005) Molecular and cellular effects of cis-9, trans-11-conjugated linoleic acid in enterocytes: Effects on proliferation, differentiation, and gene expression. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1735:1, pages 30-40.
Crossref
Séverine Cavret & Cyril Feidt. (2005) Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium. Environmental Research 98:1, pages 22-32.
Crossref
Shufeng Zhou, Xia Feng, Philip Kestell, James W. Paxton, Bruce C. Baguley & Eli Chan. (2005) Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells. European Journal of Pharmaceutical Sciences 24:5, pages 513-524.
Crossref
Eileen Brantley, Valentina Trapani, Michael C. Alley, Curtis D. Hose, Tracey D. Bradshaw, Malcolm F. G. Stevens, Edward A. Sausville & Sherman F. Stinson. (2004) FLUORINATED 2-(4-AMINO-3-METHYLPHENYL)BENZOTHIAZOLES INDUCE CYP1A1 EXPRESSION, BECOME METABOLIZED, AND BIND TO MACROMOLECULES IN SENSITIVE HUMAN CANCER CELLS. Drug Metabolism and Disposition 32:12, pages 1392-1401.
Crossref
A. Lampen, B. Ebert, L. Stumkat, J. Jacob & A. Seidel. (2004) Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1681:1, pages 38-46.
Crossref
Aramandla Ramesh, Stormy A. Walker, Darryl B. Hood, Maria D. Guillén, Klaus Schneider & Eric H. Weyand. (2016) Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons. International Journal of Toxicology 23:5, pages 301-333.
Crossref
Craig K Hallstrom, Anne M Gardner & Paul R Gardner. (2004) Nitric oxide metabolism in mammalian cells: substrate and inhibitor profiles of a NADPH-cytochrome P450 oxidoreductase-coupled microsomal nitric oxide dioxygenase. Free Radical Biology and Medicine 37:2, pages 216-228.
Crossref
Smarajit Maiti & Guangping Chen. (2003) Tamoxifen Induction of Aryl Sulfotransferase and Hydroxysteroid Sulfotransferase in Male and Female Rat Liver and Intestine. Drug Metabolism and Disposition 31:5, pages 637-644.
Crossref
Roland Buesen, Melissa Mock, Heinz Nau, Albrecht Seidel, Juergen Jacob & Alfonso Lampen. (2003) Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites. Chemico-Biological Interactions 142:3, pages 201-221.
Crossref
Roland Buesen, Melissa Mock, Albrecht Seidel, Jürgen Jacob & Alfonso Lampen. (2002) Interaction between Metabolism and Transport of Benzo[a]pyrene and Its Metabolites in Enterocytes. Toxicology and Applied Pharmacology 183:3, pages 168-178.
Crossref
V Carrière, J Chambaz & M Rousset. (2001) Intestinal responses to xenobiotics. Toxicology in Vitro 15:4-5, pages 373-378.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.