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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 5
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Research Article

Interlaboratory comparison of the assessment of P450 activities in human hepatic microsomal samples

A. R. BOOBIS Clinical Pharmacology Section, Division of Medicine, Imperial College School of Medicine, London W12 0NN, UK OE Drug Kinetics Group, Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK SanofiWinthrop Ltd, SanofiResearch Division, Willowburn Avenue, Alnwick NE66 2JH, UK Knoll Pharmaceuticals (BASF Pharma), Pennyfoot Street, Nottingham NG2 3AA, UK
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D. McKILLOP* Clinical Pharmacology Section, Division of Medicine, Imperial College School of Medicine, London W12 0NN, UK OE Drug Kinetics Group, Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK SanofiWinthrop Ltd, SanofiResearch Division, Willowburn Avenue, Alnwick NE66 2JH, UK Knoll Pharmaceuticals (BASF Pharma), Pennyfoot Street, Nottingham NG2 3AA, UK
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D. T. ROBINSON Clinical Pharmacology Section, Division of Medicine, Imperial College School of Medicine, London W12 0NN, UK OE Drug Kinetics Group, Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK SanofiWinthrop Ltd, SanofiResearch Division, Willowburn Avenue, Alnwick NE66 2JH, UK Knoll Pharmaceuticals (BASF Pharma), Pennyfoot Street, Nottingham NG2 3AA, UK
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D. A. ADAMS Clinical Pharmacology Section, Division of Medicine, Imperial College School of Medicine, London W12 0NN, UK OE Drug Kinetics Group, Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK SanofiWinthrop Ltd, SanofiResearch Division, Willowburn Avenue, Alnwick NE66 2JH, UK Knoll Pharmaceuticals (BASF Pharma), Pennyfoot Street, Nottingham NG2 3AA, UK
&
D. J. McCORMICK Clinical Pharmacology Section, Division of Medicine, Imperial College School of Medicine, London W12 0NN, UK OE Drug Kinetics Group, Safety of Medicines Department, Zeneca Pharmaceuticals, Alderley Park, Macclesfield SK10 4TG, UK SanofiWinthrop Ltd, SanofiResearch Division, Willowburn Avenue, Alnwick NE66 2JH, UK Knoll Pharmaceuticals (BASF Pharma), Pennyfoot Street, Nottingham NG2 3AA, UK
Pages 493-506 | Published online: 22 Sep 2008

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O. Pelkonen & M. Turpeinen. (2007) extrapolation of hepatic clearance: Biological tools, scaling factors, model assumptions and correct concentrations. Xenobiotica 37:10-11, pages 1066-1089.
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N. J. Proctor, G. T. Tucker & A. Rostami-Hodjegan. (2004) Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors. Xenobiotica 34:2, pages 151-178.
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Dmitri R. DavydovNadezhda Y. DavydovaJohn T. RodgersThomas H. RushmoreJeffrey P. Jones. (2017) Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences. Biochemical Journal 474:20, pages 3523-3542.
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Xiufeng Cao, Yufang Song, Jianrong Kai, Xiaoxia Yang & Puhui Ji. (2012) Evaluation of EROD and CYP3A4 activities in earthworm Eisenia fetida as biomarkers for soil heavy metal contamination. Journal of Hazardous Materials 243, pages 146-151.
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Peter Greaves. 2012. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 433 535 .
Shayne Cox GadJane R. Kenny, Dermot F. McGinnity, Ken Grime & Robert J. Riley. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
María José Gómez-Lechón, José Vicente Castell & María Teresa Donato. (2007) Hepatocytes—the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo. Chemico-Biological Interactions 168:1, pages 30-50.
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Peter Greaves. 2007. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 457 569 .
Dermot F. McGinnity, James Tucker, Steve Trigg & Robert J. Riley. (2005) PREDICTION OF CYP2C9-MEDIATED DRUG-DRUG INTERACTIONS: A COMPARISON USING DATA FROM RECOMBINANT ENZYMES AND HUMAN HEPATOCYTES. Drug Metabolism and Disposition 33:11, pages 1700-1707.
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F Eertmans, W Dhooge, S Stuyvaert & F Comhaire. (2003) Endocrine disruptors: effects on male fertility and screening tools for their assessment. Toxicology in Vitro 17:5-6, pages 515-524.
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Jarmo S. Salonen, Leena Nyman, Alan R. Boobis, Robert J. Edwards, Patricia Watts, Brian G. Lake, Roger J. Price, Anthony B. Renwick, Maria-José Gómez-Lechón, José V. Castell, Magnus Ingelman-Sundberg, Mats Hidestrand, Andre Guillouzo, Laurent Corcos, Peter S. Goldfarb, David F.V. Lewis, Päivi Taavitsainen & Olavi Pelkonen. (2003) COMPARATIVE STUDIES ON THE CYTOCHROME P450-ASSOCIATED METABOLISM AND INTERACTION POTENTIAL OF SELEGILINE BETWEEN HUMAN LIVER-DERIVED IN VITRO SYSTEMS. Drug Metabolism and Disposition 31:9, pages 1093-1102.
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Jiro Kajita, Keiko Inano, Eiichi Fuse, Takashi Kuwabara & Hiroyuki Kobayashi. (2002) Effects of Olopatadine, a New Antiallergic Agent, on Human Liver Microsomal Cytochrome P450 Activities. Drug Metabolism and Disposition 30:12, pages 1504-1511.
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Pierre Kremers. (2003) In vitro Tests for Predicting Drug‐Drug Interactions: The Need for Validated Procedures . Pharmacology & Toxicology 91:5, pages 209-217.
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Lovisa Afzelius, Ismael Zamora, Marianne Ridderström, Tommy B. Andersson, Anders Karlén & Collen M. Masimirembwa. (2001) Competitive CYP2C9 Inhibitors: Enzyme Inhibition Studies, Protein Homology Modeling, and Three-Dimensional Quantitative Structure-Activity Relationship Analysis. Molecular Pharmacology 59:4, pages 909-919.
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Hai-Zhi Bu, Kim Knuth, Lisa Magis & Philip Teitelbaum. (2001) High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. European Journal of Pharmaceutical Sciences 12:4, pages 447-452.
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Xavier Ponsoda, Eugenia Pareja, Marı́a-José Gómez-Lechón, Ricardo Fabra, Emilio Carrasco, Ramon Trullenque & José Vincente Castell. (2001) Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor. Journal of Hepatology 34:1, pages 19-25.
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Peter Greaves. 2000. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 432 544 .
Georgia J Pass, Stuart McLean & Ieva Stupans. (1999) Induction of xenobiotic metabolising enzymes in the common brushtail possum, Trichosurus vulpecula, by Eucalyptus terpenes. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 124:3, pages 239-246.
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