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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 4
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Research Article

Effect of cold and warm ischaemia on drug metabolism in isolated hepatocytes and slices from human and monkey liver

P. OLINGA Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
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M. T. MEREMA Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
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I. H. HOF Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
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M. H. DE JAGER Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
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K. P. DE JONG Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
,
M. J. H. SLOOFF Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
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D. K. F. MEIJER Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
&
G. M. M. GROOTHUIS Groningen Institute for Drug Studies, Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands OE Division of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, University Hospital, Hanzeplein 1, 9713 EZ Groningen, The Netherlands
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Pages 349-360 | Published online: 22 Sep 2008

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Gregory M. Fahy, Na Guan, Inge A. M. de Graaf, Yuansheng Tan, Lenetta Griffin & Geny M. M. Groothuis. (2013) Cryopreservation of precision-cut tissue slices. Xenobiotica 43:1, pages 113-132.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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G. I. Somers, A. J. Harris, M. K. Bayliss & J. B. Houston. (2007) The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: A comparison of and metabolism and enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes. Xenobiotica 37:8, pages 832-854.
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G. I. Somers, M. K. Bayliss & J. B. Houston. (2007) The metabolism of the 5HT3 antagonists, ondansetron, alosetron and GR87442 II: Investigation into the in vitro methods used to predict the in vivo hepatic clearance of ondansetron, alosetron and GR87442 in the rat, dog and human. Xenobiotica 37:8, pages 855-869.
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Articles from other publishers (22)

María Dolores Pizarro, María Eugenia Mamprin, Lucas Damián Daurelio, Joaquín Valentín Rodriguez & María Gabriela Mediavilla. (2018) Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance. World Journal of Hepatology 10:10, pages 719-730.
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Inge M. Westra, Henricus A.M. Mutsaers, Theerut Luangmonkong, Mackenzie Hadi, Dorenda Oosterhuis, Koert P. de Jong, Geny M.M. Groothuis & Peter Olinga. (2016) Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis. Toxicology in Vitro 35, pages 77-85.
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María Dolores Pizarro, María Gabriela Mediavilla, Alejandra Beatriz Quintana, Ángel Luis Scandizzi, Joaquín Valentín Rodriguez & María Eugenia Mamprin. (2016) Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver. World Journal of Hepatology 8:33, pages 1442.
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G. M. M. Groothuis, A. Casini, H. Meurs & P. Olinga. 2014. Human-based Systems for Translational Research. Human-based Systems for Translational Research 38 65 .
Patricio Godoy, Nicola J. Hewitt, Ute Albrecht, Melvin E. Andersen, Nariman Ansari, Sudin Bhattacharya, Johannes Georg Bode, Jennifer Bolleyn, Christoph Borner, Jan Böttger, Albert Braeuning, Robert A. Budinsky, Britta Burkhardt, Neil R. Cameron, Giovanni Camussi, Chong-Su Cho, Yun-Jaie Choi, J. Craig Rowlands, Uta Dahmen, Georg Damm, Olaf Dirsch, María Teresa Donato, Jian Dong, Steven Dooley, Dirk Drasdo, Rowena Eakins, Karine Sá Ferreira, Valentina Fonsato, Joanna Fraczek, Rolf Gebhardt, Andrew Gibson, Matthias Glanemann, Chris E. P. Goldring, María José Gómez-Lechón, Geny M. M. Groothuis, Lena Gustavsson, Christelle Guyot, David Hallifax, Seddik Hammad, Adam Hayward, Dieter Häussinger, Claus Hellerbrand, Philip Hewitt, Stefan Hoehme, Hermann-Georg Holzhütter, J. Brian Houston, Jens Hrach, Kiyomi Ito, Hartmut Jaeschke, Verena Keitel, Jens M. Kelm, B. Kevin Park, Claus Kordes, Gerd A. Kullak-Ublick, Edward L. LeCluyse, Peng Lu, Jennifer Luebke-Wheeler, Anna Lutz, Daniel J. Maltman, Madlen Matz-Soja, Patrick McMullen, Irmgard Merfort, Simon Messner, Christoph Meyer, Jessica Mwinyi, Dean J. Naisbitt, Andreas K. Nussler, Peter Olinga, Francesco Pampaloni, Jingbo Pi, Linda Pluta, Stefan A. Przyborski, Anup Ramachandran, Vera Rogiers, Cliff Rowe, Celine Schelcher, Kathrin Schmich, Michael Schwarz, Bijay Singh, Ernst H. K. Stelzer, Bruno Stieger, Regina Stöber, Yuichi Sugiyama, Ciro Tetta, Wolfgang E. Thasler, Tamara Vanhaecke, Mathieu Vinken, Thomas S. Weiss, Agata Widera, Courtney G. Woods, Jinghai James Xu, Kathy M. Yarborough & Jan G. Hengstler. (2013) Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Archives of Toxicology 87:8, pages 1315-1530.
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Na Guan, Sylvia A. Blomsma, Gregory M. Fahy, Geny M.M. Groothuis & Inge A.M. de Graaf. (2013) Analysis of gene expression changes to elucidate the mechanism of chilling injury in precision-cut liver slices. Toxicology in Vitro 27:2, pages 890-899.
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Ansar A. Khan, Edwin C.Y. Chow, Robert J. Porte, K. Sandy Pang & Geny M.M. Groothuis. (2011) The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices. Toxicology in Vitro 25:1, pages 80-90.
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Inge A M de Graaf, Peter Olinga, Marina H de Jager, Marjolijn T Merema, Ruben de Kanter, Esther G van de Kerkhof & Geny M M Groothuis. (2010) Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nature Protocols 5:9, pages 1540-1551.
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Ansar A. Khan, Bieuwke S. Dragt, Robert J. Porte & Geny M.M. Groothuis. (2010) Regulation of VDR expression in rat and human intestine and liver – Consequences for CYP3A expression. Toxicology in Vitro 24:3, pages 822-829.
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Ansar A. Khan, Edwin C. Y. Chow, Robert J. Porte, K. Sandy Pang & Geny M. M. Groothuis. (2009) Expression and regulation of the bile acid transporter, OST α ‐OST β in rat and human intestine and liver . Biopharmaceutics & Drug Disposition 30:5, pages 241-258.
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Johannes H. Proost, Leonie Beljaars, Peter Olinga, Pieter J. Swart, Mirjam E. Kuipers, Catharina Reker-Smit, Geny M.M. Groothuis & Dirk K.F. Meijer. (2006) Prediction of the pharmacokinetics of succinylated human serum albumin in man from in vivo disposition data in animals and in vitro liver slice incubations. European Journal of Pharmaceutical Sciences 27:2-3, pages 123-132.
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M. Teresa Donato, Alfonso Serralta, Nuria Jiménez, Gabriela Pérez, José V. Castell, José Mir & M. José Gómez-Lechón. (2005) LIVER GRAFTS PRESERVED IN CELSIOR SOLUTION AS SOURCE OF HEPATOCYTES FOR DRUG METABOLISM STUDIES: COMPARISON WITH SURGICAL LIVER BIOPSIES. Drug Metabolism and Disposition 33:1, pages 108-114.
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Tyler O. Kirby, Angel Rivera, Daniel Rein, Minghui Wang, Ilya Ulasov, Martina Breidenbach, Manjula Kataram, Juan L. Contreras, Carlos Krumdieck, Masato Yamamoto, Marianne G. Rots, Hidde J. Haisma, Ronald D. Alvarez, Parameshwar J. Mahasreshti & David T. Curiel. (2004) A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity . Clinical Cancer Research 10:24, pages 8697-8703.
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Nicola J HewittDietmar Utesch. (2016) Cryopreserved rat, dog and monkey hepatocytes: measurement of drug metabolizing enzymes in suspensions and cultures. Human & Experimental Toxicology 23:6, pages 307-316.
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A. Serralta, M.T. Donato, F. Orbis, J.V. Castell, J. Mir & M.J. Gómez-Lechón. (2003) Functionality of cultured human hepatocytes from elective samples, cadaveric grafts and hepatectomies. Toxicology in Vitro 17:5-6, pages 769-774.
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L.H. Cohen, R.E.W. van Leeuwen, G.C.F. van Thiel, J.F. van Pelt & S.H. Yap. (2001) Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P450 enzymes. Biopharmaceutics & Drug Disposition 21:9, pages 353-364.
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D Crenesse. (2000) Protein Kinase Activation by Warm And Cold Hypoxia- Reoxygenation in Primary-Cultured Rat Hepatocytes–JNK1/SAPK1 Involvement in Apoptosis. Hepatology 32:5, pages 1029-1036.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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R Glöckner, P Steinmetzer, C Drobner & D Müller. (1999) Use of Fresh and Cryopreserved Human Liver Slices in Toxicology with Special Reference to In vitro Induction of Cytochrome P450. Toxicology in Vitro 13:4-5, pages 531-535.
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Sandra CoeckeVera RogiersMartin BaylissJosé CastellJohannes DoehmerGérard FabreJeffrey FryArmin Kern & Carl Westmoreland. (2019) The use of Long-term Hepatocyte Cultures for Detecting Induction of Drug Metabolising Enzymes: The Current Status. Alternatives to Laboratory Animals 27:4, pages 579-638.
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Albert P Li, Chuang Lu, Julie A Brent, Chuong Pham, Andrew Fackett, Charles E Ruegg & Paul M Silber. (1999) Cryopreserved human hepatocytes: characterization of drug-metabolizing activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug–drug interaction potential. Chemico-Biological Interactions 121:1, pages 17-35.
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Roger J. Price, Anthony B. Renwick, Paula T. Barton, J. Brian Houston & Brian G. Lake. (2020) Influence of Slice Thickness and Culture Conditions on the Metabolism of 7-Ethoxycoumarin in Precision-cut Rat Liver Slices. Alternatives to Laboratory Animals 26:4, pages 541-548.
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