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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 4
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Research Article

Use of precision-cut rat liver slices for studies of xenobiotic metabolism and toxicity: comparison of the Krumdieck and Brendel tissue slicers

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Pages 361-371 | Published online: 22 Sep 2008

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Paula Viviani, Adrián L. Lifschitz, Jorge P. García, María Laura Maté, Miguel A. Quiroga, Carlos E. Lanusse & Guillermo L. Virkel. (2017) Assessment of liver slices for research on metabolic drug–drug interactions in cattle. Xenobiotica 47:11, pages 933-942.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Jean-Paul Morin, Jean-Marc Baste, Arnaud Gay, Clément Crochemore, Cécile Corbière & Christelle Monteil. (2013) Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies. Xenobiotica 43:1, pages 63-72.
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Ajit Dash, Walker Inman, Keith Hoffmaster, Samantha Sevidal, Joan Kelly, R Scott Obach, Linda G Griffith & Steven R Tannenbaum. (2009) Liver tissue engineering in the evaluation of drug safety. Expert Opinion on Drug Metabolism & Toxicology 5:10, pages 1159-1174.
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Inge AM de Graaf, Geny MM Groothuis & Peter Olinga. (2007) Precision-cut tissue slices as a tool to predict metabolism of novel drugs. Expert Opinion on Drug Metabolism & Toxicology 3:6, pages 879-898.
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P. D. Worboys & D. J. Carlile. (2001) Implications and consequences of enzyme induction on preclinical and clinical drug development. Xenobiotica 31:8-9, pages 539-556.
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Articles from other publishers (29)

Fatina Siwczak, Charlotte Hiller, Helga Pfannkuche & Marlon R. Schneider. (2023) Culture of vibrating microtome tissue slices as a 3D model in biomedical research. Journal of Biological Engineering 17:1.
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G. Janani, Smriti Priya, Souradeep Dey & Biman B. Mandal. (2022) Mimicking Native Liver Lobule Microarchitecture In Vitro with Parenchymal and Non-parenchymal Cells Using 3D Bioprinting for Drug Toxicity and Drug Screening Applications. ACS Applied Materials & Interfaces 14:8, pages 10167-10186.
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Liza Dewyse, Hendrik Reynaert & Leo A. van Grunsven. (2021) Best Practices and Progress in Precision-Cut Liver Slice Cultures. International Journal of Molecular Sciences 22:13, pages 7137.
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Julia Herbert, Debra L. Laskin, Andrew J. Gow & Jeffrey D. Laskin. (2020) Chemical warfare agent research in precision‐cut tissue slices—a useful alternative approach. Annals of the New York Academy of Sciences 1480:1, pages 44-53.
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Solene Accarias, Thibaut Sanchez, Arnaud Labrousse, Myriam Ben-Neji, Aurélien Boyance, Renaud Poincloux, Isabelle Maridonneau-Parini & Véronique Le Cabec. (2020) Genetic engineering of Hoxb8-immortalized hematopoietic progenitors – a potent tool to study macrophage tissue migration. Journal of Cell Science 133:5.
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Philippe Gui, Myriam Ben-Neji, Ekaterina Belozertseva, Florence Dalenc, Camille Franchet, Julia Gilhodes, Arnaud Labrousse, Elisabeth Bellard, Muriel Golzio, Renaud Poincloux, Isabelle Maridonneau-Parini & Véronique Le Cabec. (2018) The Protease-Dependent Mesenchymal Migration of Tumor-Associated Macrophages as a Target in Cancer Immunotherapy. Cancer Immunology Research 6:11, pages 1337-1351.
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Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Pratibha Mistry & Steven D. Webb. (2018) Impact of cell types and culture methods on the functionality of in vitro liver systems – A review of cell systems for hepatotoxicity assessment. Toxicology in Vitro 48, pages 262-275.
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Anne Granitzny, Jan Knebel, Dirk Schaudien, Armin Braun, Pablo Steinberg, Clemens Dasenbrock & Tanja Hansen. (2017) Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound. Toxicology in Vitro 42, pages 200-213.
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Viktoriia Starokozhko, Getahun B. Abza, Hedy C. Maessen, Marjolijn T. Merema, Frieke Kuper & Geny M.M. Groothuis. (2015) Viability, function and morphological integrity of precision-cut liver slices during prolonged incubation: Effects of culture medium. Toxicology in Vitro 30:1, pages 288-299.
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G. M. M. Groothuis, A. Casini, H. Meurs & P. Olinga. 2014. Human-based Systems for Translational Research. Human-based Systems for Translational Research 38 65 .
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith & Ivan Rusyn. (2013) In vitro models for liver toxicity testing. Toxicol. Res. 2:1, pages 23-39.
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Alexander V. LyubimovCostas Ioannides & Brian G. Lake. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 26 .
Alexander V. LyubimovJames M. MKim. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 28 .
Paul M. van Midwoud, Elisabeth Verpoorte & Geny M. M. Groothuis. (2011) Microfluidic devices for in vitro studies on liver drug metabolism and toxicity. Integrative Biology 3:5, pages 509.
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Inge A M de Graaf, Peter Olinga, Marina H de Jager, Marjolijn T Merema, Ruben de Kanter, Esther G van de Kerkhof & Geny M M Groothuis. (2010) Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies. Nature Protocols 5:9, pages 1540-1551.
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Martina Zimmermann, Johanna Lampe, Sebastian Lange, Irina Smirnow, Alfred Königsrainer, Claus Hann-von-Weyhern, Falko Fend, Michael Gregor, Michael Bitzer & Ulrich M. Lauer. (2009) Improved reproducibility in preparing precision-cut liver tissue slices. Cytotechnology 61:3, pages 145-152.
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Michael A. Kern, Anke M. Haugg, Eva Eiteneuer, Elisabeth Konze, Uta Drebber, Hans P. Dienes, Kai Breuhahn, Peter Schirmacher & Hans U. Kasper. (2006) Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma. Liver International 26:5, pages 604-612.
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Nils A. 't Hart, Arjan van der Plaats, Alexander Faber, Henri G.D. Leuvenink, Peter Olinga, Janneke Wiersema-Buist, Gijsbertus J. Verkerke, Gerhard Rakhorst & Rutger J. Ploeg. (2005) Oxygenation during hypothermic rat liver preservation: An in vitro slice study to demonstrate beneficial or toxic oxygenation effects. Liver Transplantation 11:11, pages 1403-1411.
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Esther F.A Brandon, Christiaan D Raap, Irma Meijerman, Jos H Beijnen & Jan H.M Schellens. (2003) An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicology and Applied Pharmacology 189:3, pages 233-246.
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I.A.M de Graaf & H.J Koster. (2003) Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicology in Vitro 17:1, pages 1-17.
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Eleni Rekka, Ekaterina Evdokimova, Stéphane Eeckhoudt, Geoffray Labar & Pedro Buc Calderon. (2002) Role of temperature on protein and mRNA cytochrome P450 3A (CYP3A) isozymes expression and midazolam oxidation by cultured rat precision-cut liver slices. Biochemical Pharmacology 64:4, pages 633-643.
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Elleni Rekka, Ekaterina Evdokimova, Stéphane Eeckhaudt & Pedro Buc Calderon. (2001) Reoxygenation after cold hypoxic storage of cultured precision-cut rat liver slices: effects on cellular metabolism and drug biotransformation. Biochimica et Biophysica Acta (BBA) - General Subjects 1568:3, pages 245-251.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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D. Müller, C. Drobner & R. Glöckner. (2000) Optimal oxygen tension conditions for viability and functioning of precision-cut liver slices. Experimental and Toxicologic Pathology 52:4, pages 335-338.
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P. Schmieder, M. Tapper, A. Linnum, J. Denny, R. Kolanczyk & R. Johnson. (2000) Optimization of a precision-cut trout liver tissue slice assay as a screen for vitellogenin induction: comparison of slice incubation techniques. Aquatic Toxicology 49:4, pages 251-268.
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A.D. Shilling & D.E. Williams. (2000) Determining Relative Estrogenicity by Quantifying Vitellogenin Induction in Rainbow Trout Liver Slices. Toxicology and Applied Pharmacology 164:3, pages 330-335.
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R De Kanter, P Olinga, M.H De Jager, M.T Merema, D.K.F Meijer & G.M.M Groothius. (1999) Organ Slices as an In Vitro Test System for Drug Metabolism in Human Liver, Lung and Kidney. Toxicology in Vitro 13:4-5, pages 737-744.
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J.C. Phillips, S. Davies & B.G. Lake. (1999) Dose-response relationships for hepatic aflatoxin B1-DNA adduct formation in the rat in vivo and in vitro: The use of immunoslot blotting for adduct quantitation. Teratogenesis, Carcinogenesis, and Mutagenesis 19:2, pages 157-170.
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Roger J. Price, Anthony B. Renwick, Paula T. Barton, J. Brian Houston & Brian G. Lake. (2020) Influence of Slice Thickness and Culture Conditions on the Metabolism of 7-Ethoxycoumarin in Precision-cut Rat Liver Slices. Alternatives to Laboratory Animals 26:4, pages 541-548.
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