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Xenobiotica
the fate of foreign compounds in biological systems
Volume 28, 1998 - Issue 1
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Research Article

Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man

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Pages 63-75 | Published online: 22 Sep 2008

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Jayaprakasam Bolleddula, Kevin DeMent, James P. Driscoll, Philip Worboys, Patrick J. Brassil & David L. Bourdet. (2014) Biotransformation and bioactivation reactions of alicyclic amines in drug molecules. Drug Metabolism Reviews 46:3, pages 379-419.
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Umberto Leone Roberti Maggiore, Stefano Salvatore, Franco Alessandri, Valentino Remorgida, Massimo Origoni, Massimo Candiani, Pier Luigi Venturini & Simone Ferrero. (2012) Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females. Expert Opinion on Drug Metabolism & Toxicology 8:11, pages 1387-1408.
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Norman, Zinner. (2007) Darifenacin: a muscarinic M3-selective receptor antagonist for the treatment of overactive bladder. Expert Opinion on Pharmacotherapy 8:4, pages 511-523.
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Arun Sahai, Mohammed Shamim Khan, Manit Arya, Jason John, Rajinder Singh & Hitendra RH Patel. (2006) The overactive bladder: review of current pharmacotherapy in adults. Part 1: pathophysiology and anticholinergic therapy. Expert Opinion on Pharmacotherapy 7:5, pages 509-527.
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Swati Jha & Matthew Parsons. (2006) Treatment of overactive bladder in the aging population: focus on darifenacin. Clinical Interventions in Aging 1:4, pages 309-316.
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Christopher R Chapple. (2004) Darifenacin: a novel M3 muscarinic selective receptor antagonist for the treatment of overactive bladder. Expert Opinion on Investigational Drugs 13:11, pages 1493-1500.
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Articles from other publishers (24)

Shanna C. Trenaman, Susan K. Bowles, Melissa K. Andrew & Kerry Goralski. (2021) The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs. Pharmacology Research & Perspectives 9:3.
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Kuanglei Wang, Hongxi Zhu, Hongqian Zhao, Kun Zhang & Yongshou Tian. (2020) Application of carbamyl in structural optimization. Bioorganic Chemistry 98, pages 103757.
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Oliver Fischer, Josefa Hofmann, Hannelore Rampp, Jonas Kaindl, Gerald Pratsch, Amelie Bartuschat, R. Verena Taudte, Martin F. Fromm, Harald Hübner, Peter Gmeiner & Markus R. Heinrich. (2020) Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists. Journal of Medicinal Chemistry 63:8, pages 4349-4369.
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Hongtao LiuJosefa HofmannInbar FishBenjamin SchaakeKatrin EitelAmelie BartuschatJonas KaindlHannelore RamppAshutosh BanerjeeHarald HübnerMary J. ClarkSandra G. VincentJohn T. FisherMarkus R. HeinrichKunio HirataXiangyu LiuRoger K. SunaharaBrian K. ShoichetBrian K. Kobilka & Peter Gmeiner. (2018) Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. Proceedings of the National Academy of Sciences 115:47, pages 12046-12050.
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M.M. Hefnawy, A.M. Alanazi, M.A. Abounassif, M.S. Mohammed, Sabry M. Attia & G.A.E. Mostafa. (2014) Validated liquid chromatographic–fluorescence method for the quantitation of darifenacin in mice plasma and its application to a pharmacokinetic study. Talanta 121, pages 37-42.
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Jing Dai. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Thejomoorthy Karavadi & B. R. Challa. (2012) Method Development and Validation of Darifenacin in Rat Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study. ISRN Spectroscopy 2012, pages 1-9.
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Donald J. AbrahamJulian Blagg. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 301 334 .
Karl-Erik Andersson, Claudius Fullhase & Roberto Soler. (2008) Urothelial effects of oral agents for overactive bladder. Current Urology Reports 9:6, pages 459-464.
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Bertil FM Blok & Jacques Corcos. (2007) Darifenacin for the treatment of overactive bladder. Aging Health 3:2, pages 143-147.
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Richard Jewell. 2007. xPharm: The Comprehensive Pharmacology Reference. xPharm: The Comprehensive Pharmacology Reference 1 5 .
CR Chapple. (2006) The contemporary pharmacological management of overactive bladder. BJOG: An International Journal of Obstetrics & Gynaecology 113, pages 19-28.
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Martin C. Michel & Sharath S. Hegde. (2006) Treatment of the overactive bladder syndrome with muscarinic receptor antagonists - a matter of metabolites?. Naunyn-Schmiedeberg's Archives of Pharmacology 374:2, pages 79-85.
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Andrej Skerjanec. (2006) The Clinical Pharmacokinetics of Darifenacin. Clinical Pharmacokinetics 45:4, pages 325-350.
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Jean-Philippe Starck, Patrice Talaga, Luc Quéré, Philippe Collart, Bernard Christophe, Patrick Lo Brutto, Sophie Jadot, Dinesh Chimmanamada, Matteo Zanda, Alain Wagner, Charles Mioskowski, Roy Massingham & Michel Guyaux. (2006) Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorganic & Medicinal Chemistry Letters 16:2, pages 373-377.
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François Haab. (2016) Darifenacin for the Treatment of Overactive Bladder. Women's Health 1:3, pages 331-343.
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M. Parsons, D. Robinson & L. Cardozo. (2005) Darifenacin in the treatment of overactive bladder. International Journal of Clinical Practice 59:7, pages 831-838.
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David R. P. Guay. (2005) Darifenacin: Another Antimuscarinic for Overactive Bladder. The Consultant Pharmacist 20:5, pages 424-431.
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Thomas Kerbusch, Peter A. Milligan & Mats O. Karlsson. (2003) Assessment of the relative in vivo potency of the hydroxylated metabolite of darifenacin in its ability to decrease salivary flow using pooled population pharmacokinetic-pharmacodynamic data. British Journal of Clinical Pharmacology 57:2, pages 170-180.
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Thomas Kerbusch, Ulrika Wählby, Peter A. Milligan & Mats O. Karlsson. (2003) Population pharmacokinetic modelling of darifenacin and its hydroxylated metabolite using pooled data, incorporating saturable first-pass metabolism, CYP2D6 genotype and formulation-dependent bioavailability . British Journal of Clinical Pharmacology 56:6, pages 639-652.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Koichi Miyamae, Masaki Yoshida, Shigetaka Murakami, Hitoshi Iwashita, Masayuki Ohtani, Koichi Masunaga & Shoichi Ueda. (2003) Pharmacological Effects of Darifenacin on Human Isolated Urinary Bladder. Pharmacology 69:4, pages 205-211.
Crossref
Bernd Disse. 2001. Muscarinic Receptors in Airways Diseases. Muscarinic Receptors in Airways Diseases 221 258 .
R. F. Venn & R. J. Goody. (1999) Synthesis and properties of molecular imprints of darifenacin: The potential of molecular imprinting for bioanalysis. Chromatographia 50:7-8, pages 407-414.
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