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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 12
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Research Article

Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells

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Pages 1241-1256 | Published online: 22 Sep 2008

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Dimitrios Diamantis, Antonios D. Tsiailanis, Christina Papaemmanouil, Maria-Christina Nika, Zoi Kanaki, Simona Golic Grdadolnik, Andrej Babic, Eleftherios Paraskevas Tzakos, Isabelle Fournier, Michel Salzet, Prem Prakash Kushwaha, Nikolaos S. Thomaidis, Theodoros Rampias, Eswar Shankar, Serdar Karakurt, Sanjay Gupta & Andreas G. Tzakos. (2023) Development of a novel apigenin prodrug programmed for alkaline-phosphatase instructed self-inhibition to combat cancer. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-22.
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Yong Qu, Shunda Mu, Chengwu Song & Guohua Zheng. (2021) Preparation and in vitro/in vivo evaluation of a self-microemulsifying drug delivery system containing chrysin. Drug Development and Industrial Pharmacy 47:7, pages 1127-1139.
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Chunli Qi, Jiangnan Fu, Huinan Zhao, Huijie Xing, Dong Dong & Baojian Wu. (2019) Identification of UGTs and BCRP as potential pharmacokinetic determinants of the natural flavonoid alpinetin. Xenobiotica 49:3, pages 276-283.
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Ding Tang, Keli Chen, Luqi Huang & Juan Li. (2017) Pharmacokinetic properties and drug interactions of apigenin, a natural flavone. Expert Opinion on Drug Metabolism & Toxicology 13:3, pages 323-330.
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Ursula Gundert-Remy, Ulrike Bernauer, Brunhilde Blömeke, Barbara Döring, Eric Fabian, Carsten Goebel, Stefanie Hessel, Christine Jäckh, Alfonso Lampen, Franz Oesch, Ernst Petzinger, Wolfgang Völkel & Peter H. Roos. (2014) Extrahepatic metabolism at the body's internal–external interfaces. Drug Metabolism Reviews 46:3, pages 291-324.
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Yin Cheong Wong, Li Zhang, Ge Lin & Zhong Zuo. (2009) Structure–activity relationships of the glucuronidation of flavonoids by human glucuronosyltransferases. Expert Opinion on Drug Metabolism & Toxicology 5:11, pages 1399-1419.
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Rainer Cermak. (2008) Effect of dietary flavonoids on pathways involved in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 4:1, pages 17-35.
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Marc Vermeir, Pieter Annaert, Rao NVS Mamidi, Dirk Roymans, Willem Meuldermans & Geert Mannens. (2005) Cell-based models to study hepatic drug metabolism and enzyme induction in humans. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 75-90.
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C. De Santi, A. Pietrabissa, R. Spisni, F. Mosca & G. M. Pacifici. (2000) Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica 30:9, pages 857-866.
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Articles from other publishers (85)

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Daniel-Ioan Hădărugă & Nicoleta-Gabriela Hădărugă. 2022. Handbook of Food Bioactive Ingredients. Handbook of Food Bioactive Ingredients 1 48 .
Shreya Chitrakant Adangale & Sarika Wairkar. (2022) Potential therapeutic activities and novel delivery systems of chrysin-a nature’s boon. Food Bioscience 45, pages 101316.
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Song Gao, Nyma Siddiqui, Imoh Etim, Ting Du, Yun Zhang & Dong Liang. (2021) Developing nutritional component chrysin as a therapeutic agent: Bioavailability and pharmacokinetics consideration, and ADME mechanisms. Biomedicine & Pharmacotherapy 142, pages 112080.
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Pisamai Ting, Wanwisa Srinuanchai, Uthaiwan Suttisansanee, Siriporn Tuntipopipat, Somsri Charoenkiatkul, Kemika Praengam, Boonrat Chantong, Piya Temviriyanukul & Onanong Nuchuchua. (2021) Development of Chrysin Loaded Oil-in-Water Nanoemulsion for Improving Bioaccessibility. Foods 10:8, pages 1912.
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Ya-Di Zhu, Xiao-Qing Guan, Jing Chen, Sheng Peng, Moshe Finel, Ying-Yuan Zhao, Rui-Min Wang, Hui-Chang Bi, Ming Lei, Dan-Dan Wang & Guang-Bo Ge. (2021) Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ. Frontiers in Pharmacology 11.
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Diana El-Hussien, Ghada M. El-Zaafarany, Maha Nasr & Omaima Sammour. (2021) Chrysin nanocapsules with dual anti-glycemic and anti-hyperlipidemic effects: Chemometric optimization, physicochemical characterization and pharmacodynamic assessment. International Journal of Pharmaceutics 592, pages 120044.
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Iman O. Sherif, Laila A. Al-Mutabagani, Dina Sabry & Nehal M. Elsherbiny. (2020) Antineoplastic Activity of Chrysin against Human Hepatocellular Carcinoma: New Insight on GPC3/SULF2 Axis and lncRNA-AF085935 Expression. International Journal of Molecular Sciences 21:20, pages 7642.
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Mark I Kaldas, U Kristina Walle & Thomas Walle. (2003) Resveratrol transport and metabolism by human intestinal Caco-2 cells. Journal of Pharmacy and Pharmacology 55:3, pages 307-312.
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Akkarach Bumrungpert, Ruchaneekorn W. Kalpravidh, Sunit Suksamrarn, Apinya Chaivisuthangkura, Chureeporn Chitchumroonchokchai & Mark L. Failla. (2009) Bioaccessibility, biotransformation, and transport of α‐mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco‐2 human intestinal cells . Molecular Nutrition & Food Research 53:S1.
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Rachel J Gibson & Andrea M Stringer. (2009) Chemotherapy-induced diarrhoea. Current Opinion in Supportive & Palliative Care 3:1, pages 31-35.
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Yin Cheong Wong, Li Zhang, Ge Lin & Zhong Zuo. (2009) Intestinal first-pass glucuronidation activities of selected dihydroxyflavones. International Journal of Pharmaceutics 366:1-2, pages 14-20.
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Xiaodong Wang & Marilyn E. Morris. (2008) Pharmacokinetics and Bioavailability of the Flavonoid 7,8-Benzoflavone in Rats. Journal of Pharmaceutical Sciences 97:10, pages 4546-4556.
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Walter Brand, Petronella A. I. van der Wel, Maarit J. Rein, Denis Barron, Gary Williamson, Peter J. van Bladeren & Ivonne M. C. M. Rietjens. (2008) Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers. Drug Metabolism and Disposition 36:9, pages 1794-1802.
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Robert E. Steinert, Bianka Ditscheid, Michael Netzel & Gerhard Jahreis. (2008) Absorption of Black Currant Anthocyanins by Monolayers of Human Intestinal Epithelial Caco-2 Cells Mounted in Ussing Type Chambers. Journal of Agricultural and Food Chemistry 56:13, pages 4995-5001.
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Young Jin Moon & Marilyn E. Morris. (2007) Pharmacokinetics and Bioavailability of the Bioflavonoid Biochanin A: Effects of Quercetin and EGCG on Biochanin A Disposition in Rats. Molecular Pharmaceutics 4:6, pages 865-872.
Crossref
Thomas Walle. (2007) Methylation of Dietary Flavones Greatly Improves Their Hepatic Metabolic Stability and Intestinal Absorption. Molecular Pharmaceutics 4:6, pages 826-832.
Crossref
Din Ung & Swati Nagar. (2007) Variable Sulfation of Dietary Polyphenols by Recombinant Human Sulfotransferase (SULT) 1A1 Genetic Variants and SULT1E1. Drug Metabolism and Disposition 35:5, pages 740-746.
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Xiaodong Wang & Marilyn E. Morris. (2007) Effects of the Flavonoid Chrysin on Nitrofurantoin Pharmacokinetics in Rats: Potential Involvement of ABCG2. Drug Metabolism and Disposition 35:2, pages 268-274.
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Ting Chen, Li, Xin-Yan Lu, Hui-Di Jiang & Su Zeng. (2006) Absorption and Excretion of Luteolin and Apigenin in Rats after Oral Administration of Chrysanthemum morifolium Extract . Journal of Agricultural and Food Chemistry 55:2, pages 273-277.
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Caroline Laurent, Pierre Besançon & Bertrand Caporiccio. (2007) Flavonoids from a grape seed extract interact with digestive secretions and intestinal cells as assessed in an in vitro digestion/Caco-2 cell culture model. Food Chemistry 100:4, pages 1704-1712.
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Petra A. Tsuji, Richard N. Winn & Thomas Walle. (2006) Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. Chemico-Biological Interactions 164:1-2, pages 85-92.
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Mika Hamada, Hideo Satsu, Yayoi Natsume, Shin Nishiumi, Itsuko Fukuda, Hitoshi Ashida & Makoto Shimizu. (2006) TCDD-Induced CYP1A1 Expression, an Index of Dioxin Toxicity, Is Suppressed by Flavonoids Permeating the Human Intestinal Caco-2 Cell Monolayers. Journal of Agricultural and Food Chemistry 54:23, pages 8891-8898.
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Jingli Zhang, Roger A. Stanley, Aselle Adaim, Laurence D. Melton & Margot A. Skinner. (2006) Free radical scavenging and cytoprotective activities of phenolic antioxidants. Molecular Nutrition & Food Research 50:11, pages 996-1005.
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Dejan Nikolic, Yongmei Li, Lucas R. Chadwick & Richard B. van Breemen. (2006) In Vitro Studies of Intestinal Permeability and Hepatic and Intestinal Metabolism of 8-Prenylnaringenin, a Potent Phytoestrogen from Hops (Humulus lupulus L.). Pharmaceutical Research 23:5, pages 864-872.
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Jeanelle Boyer, Dan Brown & Rui Hai Liu. (2005) In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer. Nutrition Journal 4:1.
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Cornelia M. Smith, Richard A. Graham, Wojciech L. Krol, Ivin S. Silver, Masahiko Negishi, Hongbing Wang & Edward L. Lecluyse. (2005) Differential UGT1A1 Induction by Chrysin in Primary Human Hepatocytes and HepG2 Cells. Journal of Pharmacology and Experimental Therapeutics 315:3, pages 1256-1264.
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Shuzhong Zhang, Xiaodong Wang, Kazuko Sagawa & Marilyn E. Morris. (2005) FLAVONOIDS CHRYSIN AND BENZOFLAVONE, POTENT BREAST CANCER RESISTANCE PROTEIN INHIBITORS, HAVE NO SIGNIFICANT EFFECT ON TOPOTECAN PHARMACOKINETICS IN RATS OR MDR1A/1B (–/–) MICE. Drug Metabolism and Disposition 33:3, pages 341-348.
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Abdel-Rahim Sayed Ibrahim. (2005) Biotransformation of Chrysin and Apigenin by Cunninghamella elegans. Chemical and Pharmaceutical Bulletin 53:6, pages 671-673.
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Thomayant Prueksaritanont, Karen M. Richards, Yue Qiu, Kristine Strong-Basalyga, Alisha Miller, Chunze Li, Roy Eisenhandler & Edward J. Carlini. (2005) Comparative Effects of Fibrates on Drug Metabolizing Enzymes in Human Hepatocytes. Pharmaceutical Research 22:1, pages 71-78.
Crossref
Thomas Walle, Faye Hsieh, Mark H. DeLegge, John E. OatisJr.Jr. & U. Kristina Walle. (2004) HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS. Drug Metabolism and Disposition 32:12, pages 1377-1382.
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Jeanelle Boyer, Dan Brown & Rui Hai Liu. (2004) Uptake of Quercetin and Quercetin 3-Glucoside from Whole Onion and Apple Peel Extracts by Caco-2 Cell Monolayers. Journal of Agricultural and Food Chemistry 52:23, pages 7172-7179.
Crossref
Giuseppe Galati & Peter J O'Brien. (2004) Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radical Biology and Medicine 37:3, pages 287-303.
Crossref
Muriel J. Montbriand. (2004) Herbs or Natural Products That Decrease Cancer Growth: Part One of a Four-Part Series. Oncology Nursing Forum 31:4, pages E75-E90.
Crossref
M S DuPont, A J Day, R N Bennett, F A Mellon & P A Kroon. (2004) Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans. European Journal of Clinical Nutrition 58:6, pages 947-954.
Crossref
Morgan, Joseph Rothwell & Andrea Day. 2004. Phytochemicals in Health and Disease. Phytochemicals in Health and Disease 57 76 .
Elzbieta M. Kurowska & John A. Manthey. (2004) Hypolipidemic Effects and Absorption of Citrus Polymethoxylated Flavones in Hamsters with Diet-Induced Hypercholesterolemia. Journal of Agricultural and Food Chemistry 52:10, pages 2879-2886.
Crossref
Thomas Walle. (2004) Absorption and metabolism of flavonoids. Free Radical Biology and Medicine 36:7, pages 829-837.
Crossref
Elzbieta M. Kurowska, John A. Manthey, Adele Casaschi & Andre G. Theriault. (2004) Modulation of hepG2 cell net apolipoprotein B secretion by the citrus polymethoxyflavone, tangeretin. Lipids 39:2, pages 143-151.
Crossref
Angéline Gradolatto, Marie-Chantal Canivenc-Lavier, Jean-Philippe Basly, Marie-Hélène Siess & Caroline Teyssier. (2004) METABOLISM OF APIGENIN BY RAT LIVER PHASE I AND PHASE II ENZYMES AND BY ISOLATED PERFUSED RAT LIVER. Drug Metabolism and Disposition 32:1, pages 58-65.
Crossref
Ming Hu, June Chen & Huimin Lin. (2003) Metabolism of Flavonoids via Enteric Recycling: Mechanistic Studies of Disposition of Apigenin in the Caco-2 Cell Culture Model. Journal of Pharmacology and Experimental Therapeutics 307:1, pages 314-321.
Crossref
D.G Watson, C Atsriku & E.J Oliveira. (2003) Review role of liquid chromatography–mass spectrometry in the analysis of oxidation products and antioxidants in biological systems. Analytica Chimica Acta 492:1-2, pages 17-47.
Crossref
Esther F.A Brandon, Christiaan D Raap, Irma Meijerman, Jos H Beijnen & Jan H.M Schellens. (2003) An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicology and Applied Pharmacology 189:3, pages 233-246.
Crossref
Thomas Walle, Timothy S. Vincent & U.Kristina Walle. (2003) Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells. Biochemical Pharmacology 65:10, pages 1603-1610.
Crossref
Jun Chen, Huimin Lin & Ming Hu. (2003) Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition. Journal of Pharmacology and Experimental Therapeutics 304:3, pages 1228-1235.
Crossref
Karen A O’Leary, Andrea J Day, Paul W Needs, Fred A Mellon, Nora M O’Brien & Gary Williamson. (2003) Metabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human β-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolism. Biochemical Pharmacology 65:3, pages 479-491.
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Yoko Otake, Faye Hsieh & Thomas Walle. (2002) Glucuronidation versus Oxidation of the Flavonoid Galangin by Human Liver Microsomes and Hepatocytes. Drug Metabolism and Disposition 30:5, pages 576-581.
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U. Kristina Walle & Thomas Walle. (2002) Induction of Human UDP-Glucuronosyltransferase UGT1A1 by Flavonoids—Structural Requirements. Drug Metabolism and Disposition 30:5, pages 564-569.
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Yoko Otake & Thomas Walle. (2002) Oxidation of the Flavonoids Galangin and Kaempferide by Human Liver Microsomes and CYP1A1, CYP1A2, and CYP2C9. Drug Metabolism and Disposition 30:2, pages 103-105.
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Stephanie Deprez, Isabelle Mila, Jean-François Huneau, Daniel Tome & Augustin Scalbert. (2001) Transport of Proanthocyanidin Dimer, Trimer, and Polymer Across Monolayers of Human Intestinal Epithelial Caco-2 Cells. Antioxidants & Redox Signaling 3:6, pages 957-967.
Crossref
Vanessa Crespy, Christine Morand, Catherine Besson, Claudine Manach, Christian Démigné & Christian Rémésy. (2001) Comparison of the Intestinal Absorption of Quercetin, Phloretin and Their Glucosides in Rats. The Journal of Nutrition 131:8, pages 2109-2114.
Crossref
Jennifer L. Donovan, Vanessa Crespy, Claudine Manach, Christine Morand, Catherine Besson, Augustin Scalbert & Christian Rémésy. (2001) Catechin Is Metabolized by Both the Small Intestine and Liver of Rats. The Journal of Nutrition 131:6, pages 1753-1757.
Crossref
T. Walle, Y. Otake, J. A. Brubaker, U. K. Walle & P. V. Halushka. (2008) Disposition and metabolism of the flavonoid chrysin in normal volunteers. British Journal of Clinical Pharmacology 51:2, pages 143-146.
Crossref
Andrea J Day, Yongping Bao, Michael R.A Morgan & Gary Williamson. (2000) Conjugation position of quercetin glucuronides and effect on biological activity. Free Radical Biology and Medicine 29:12, pages 1234-1243.
Crossref
Thomas Walle, Yoko Otake, U. Kristina Walle & Frederick A. Wilson. (2000) Quercetin Glucosides Are Completely Hydrolyzed in Ileostomy Patients before Absorption. The Journal of Nutrition 130:11, pages 2658-2661.
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E. J. Oliveira & D. G. Watson. (2000) Liquid chromatography-mass spectrometry in the study of the metabolism of drugs and other xenobiotics. Biomedical Chromatography 14:6, pages 351-372.
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