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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 10
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Research Article

Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4

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Pages 973-986 | Published online: 22 Sep 2008

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Read on this site (5)

Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
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Fu-Chuo Peng, Chaing Hsin-Hui, Tang Sheng-Hui, Chen Pei-Chun & Lu Shao-Chun. (2004) Nadph-Cytochrome P-450 Reductase is Involved in Flunitrazepam Reductive Metabolism in Hep G2 and Hep 3b Cells. Journal of Toxicology and Environmental Health, Part A 67:2, pages 109-124.
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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Maurice Wilde, Volker Auwärter & Bjoern Moosmann. (2021) New psychoactive substances—Designer benzodiazepines. WIREs Forensic Science 3:6.
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Rahul Patel, James Barker & Amr ElShaer. (2020) Pharmaceutical Excipients and Drug Metabolism: A Mini-Review. International Journal of Molecular Sciences 21:21, pages 8224.
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Jui-Kang Tsai, Chia-Nan Yen, Cheng-Sheng Chen, Tzung-Jeng Hwang, Shao-Tsu Chen, Tzu-Ting Chen, Chih-Hung Ko, Po-Wen Su, Yu-Ping Chang, Jin-Jia Lin & Cheng-Fang Yen. (2017) Prevalence and clinical correlates of flunitrazepam-related complex sleep behaviors. Psychiatry and Clinical Neurosciences 71:3, pages 198-203.
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Maria Katselou, Ioannis Papoutsis, Panagiota Nikolaou, Chara Spiliopoulou & Sotiris Athanaselis. (2016) Metabolites replace the parent drug in the drug arena. The cases of fonazepam and nifoxipam. Forensic Toxicology 35:1, pages 1-10.
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Béla Kiss, Catalina Bogdan, Anca Pop & Felicia Loghin. (2012) A rapid UPLC–MS/MS method for simultaneous determination of flunitrazepam, 7-aminoflunitrazepam, methadone and EDDP in human, rat and rabbit plasma. Talanta 99, pages 649-659.
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David E. Moody. 2012. Handbook of Drug Interactions. Handbook of Drug Interactions 25 116 .
Dan Li, Yonglong Han, Xiangle Meng, Xipeng Sun, Qi Yu, Yan Li, Lili Wan, Yan Huo & Cheng Guo. (2010) Effect of Regular Organic Solvents on Cytochrome P450-Mediated Metabolic Activities in Rat Liver Microsomes: Fig. 1.. Drug Metabolism and Disposition 38:11, pages 1922-1925.
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Arun K. Tiwari, Renan P. Souza & Daniel J. Müller. (2009) Pharmacogenetics of anxiolytic drugs. Journal of Neural Transmission 116:6, pages 667-677.
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T. Fukasawa, A. Suzuki & K. Otani. (2007) Effects of genetic polymorphism of cytochrome P450 enzymes on the pharmacokinetics of benzodiazepines. Journal of Clinical Pharmacy and Therapeutics 32:4, pages 333-341.
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M Iwase, N Kurata, R Ehana, Y Nishimura, T Masamoto & H Yasuhara. (2016) Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro . Human & Experimental Toxicology 25:12, pages 715-721.
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Sharon J. Gardiner & Evan J. Begg. (2006) Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice. Pharmacological Reviews 58:3, pages 521-590.
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Ophelia Q. P. Yin, Brian Tomlinson, Albert H. L. Chow, Mary M. Y. Waye & Moses S. S. Chow. (2013) Omeprazole as a CYP2C19 Marker in Chinese Subjects: Assessment of Its Gene‐Dose Effect and Intrasubject Variability. The Journal of Clinical Pharmacology 44:6, pages 582-589.
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Mark R. Hutchinson, Andrew Menelaou, David J. R. Foster, Janet K. Coller & Andrew A. Somogyi. (2003) CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. British Journal of Clinical Pharmacology 57:3, pages 287-297.
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Toshimasa TanakaNaomi KamiguchiTeruaki OkudaYoshio Yamamoto. (2004) Characterization of the CYP2C8 Active Site by Homology Modeling. Chemical and Pharmaceutical Bulletin 52:7, pages 836-841.
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David E. Moody. 2004. Handbook of Drug Interactions. Handbook of Drug Interactions 3 88 .
I. Gafni, U. E. Busto, R. F. Tyndale, H. L. Kaplan & E. M. Sellers. (2003) The Role of Cytochrome P450 2C19 Activity in Flunitrazepam Metabolism In Vivo. Journal of Clinical Psychopharmacology 23:2, pages 169-175.
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Zeruesenay Desta, Xiaojiong Zhao, Jae-Gook Shin & David A. Flockhart. (2002) Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism. Clinical Pharmacokinetics 41:12, pages 913-958.
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Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (2013) Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models. The Journal of Clinical Pharmacology 41:11, pages 1149-1179.
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Chin‐Eng Ong, Sally Coulter, Donald J. Birkett, C. Ramana Bhasker & John O. Miners. (2008) The xenobiotic inhibitor profile of cytochrome P4502C8. British Journal of Clinical Pharmacology 50:6, pages 573-580.
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