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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 9
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Research Article

Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid

K. Taguchi Pharmacokinetic Research Section, Research and Development Laboratories, Maruho Co., Ltd, 1 Awatocho, Chudoji, Shimogyoku, Kyoto 6008815, Japan
,
T. Konishi Pharmacokinetic Research Section, Research and Development Laboratories, Maruho Co., Ltd, 1 Awatocho, Chudoji, Shimogyoku, Kyoto 6008815, Japan
,
H. Nishikawa Pharmacokinetic Research Section, Research and Development Laboratories, Maruho Co., Ltd, 1 Awatocho, Chudoji, Shimogyoku, Kyoto 6008815, Japan
&
S. Kitamura Pharmacokinetic Research Section, Research and Development Laboratories, Maruho Co., Ltd, 1 Awatocho, Chudoji, Shimogyoku, Kyoto 6008815, Japan
Pages 899-907 | Published online: 22 Sep 2008

Citations (9)

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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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Articles from other publishers (8)

Yoshiya Yamamura, Kouichi Yoshinari & Yasushi Yamazoe. (2023) Construction of a fused grid-based CYP2C19-Template system and the application. Drug Metabolism and Pharmacokinetics 48, pages 100481.
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Derek R. Boyd, Narain D. Sharma, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen & Patrick M. Dansette. (2022) Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation. International Journal of Molecular Sciences 23:2, pages 909.
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Valérie Campagna-Slater, Joshua Pottel, Eric Therrien, Louis-David Cantin & Nicolas Moitessier. (2012) Development of a Computational Tool to Rival Experts in the Prediction of Sites of Metabolism of Xenobiotics by P450s. Journal of Chemical Information and Modeling 52:9, pages 2471-2483.
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Shu-Feng Zhou, Zhi-Wei Zhou & Min Huang. (2010) Polymorphisms of human cytochrome P450 2C9 and the functional relevance. Toxicology 278:2, pages 165-188.
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Sepuri Asha & Maravajhala Vidyavathi. (2009) Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review. Applied Biochemistry and Biotechnology 160:6, pages 1699-1722.
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Matthew J. Sykes, Ross A. McKinnon & John O. Miners. (2008) Prediction of Metabolism by Cytochrome P450 2C9: Alignment and Docking Studies of a Validated Database of Substrates. Journal of Medicinal Chemistry 51:4, pages 780-791.
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Michael E. Beck. (2005) Do Fukui Function Maxima Relate to Sites of Metabolism? A Critical Case Study. Journal of Chemical Information and Modeling 45:2, pages 273-282.
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Ismael Zamora, Lovisa Afzelius & Gabriele Cruciani. (2003) Predicting Drug Metabolism:  A Site of Metabolism Prediction Tool Applied to the Cytochrome P450 2C9. Journal of Medicinal Chemistry 46:12, pages 2313-2324.
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