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Xenobiotica
the fate of foreign compounds in biological systems
Volume 29, 1999 - Issue 4
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Research Article

Microsomal metabolism of N,N-diethyl-m-toluamide (DEET, DET): the extended network of metabolites

LUIS CONSTANTINO CECF, Faculdade de Farmacia, Avenida das Fort as Armadas, 1600 Lisbon, Portugal
&
JIM ILEY CECF, Faculdade de Farmacia, Avenida das Fort as Armadas, 1600 Lisbon, Portugal
Pages 409-416 | Published online: 22 Sep 2008

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G. Patlewicz, O. Mekenyan, G. Dimitrova, C. Kuseva, M. Todorov, S. Kotov, S. Stoeva & E.M. Donner. (2010) Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization?. SAR and QSAR in Environmental Research 21:7-8, pages 619-656.
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A. W. Abu-Qare & M. B. Abou-Donia. (2008) metabolism and interactions of pyridostigmine bromide, ,-diethyl--toluamide, and permethrin in human plasma and liver microsomal enzymes. Xenobiotica 38:3, pages 294-313.
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AqelW. Abu-Qare & MohamedB. Abou-Donia. (2003) Combined Exposure to Deet (N,N-Diethyl-m-Toluamide) and Permethrin: Pharmacokinetics and Toxicological Effects. Journal of Toxicology and Environmental Health, Part B 6:1, pages 41-53.
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Articles from other publishers (16)

Maciej Giedyk & Agnieszka Kamińska. 2022. Photochemistry. Photochemistry 371 385 .
Jennifer C. Gibson, Leonora Marro, Michael M. Borghese, Danielle Brandow, Lauren Remedios, Mandy Fisher, Morie Malowany, Katarzyna Kieliszkiewicz, Anna O. Lukina & Kim Irwin. (2022) Development of an observational exposure human biomonitoring study to assess Canadian children’s DEET exposure during protective use. PLOS ONE 17:8, pages e0268341.
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Martyna Cybularczyk-Cecotka, Jędrzej Predygier, Stefano Crespi, Joanna Szczepanik & Maciej Giedyk. (2022) Photocatalysis in Aqueous Micellar Media Enables Divergent C–H Arylation and N -Dealkylation of Benzamides . ACS Catalysis 12:6, pages 3543-3549.
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Li Ping Li, Joseph K.C. Kwan & King Lun Yeung. (2019) An investigation of the transformation, kinetics and bioactivity of ozone treatment of DEET in water. Chemical Engineering Journal 368, pages 10-17.
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Claudia V Vassena, Mariano Cáceres & Pablo L Santo-Orihuela. (2019) Pyrethroid Resistance Associated With a Decreased DEET Repellency in the Common Bed Bug (Hemiptera: Cimicidae). Journal of Economic Entomology 112:2, pages 997-1000.
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Raúl A. Alzogaray. (2016) Behavioral and Toxicological Responses of Rhodnius prolixus (Hemiptera: Reduviidae) to the Insect Repellents DEET and IR3535 . Journal of Medical Entomology 53:2, pages 387-393.
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Lih-Ming Yiin, Jia-Ni Tian & Chien-Che Hung. (2014) Assessment of dermal absorption of DEET-containing insect repellent and oxybenzone-containing sunscreen using human urinary metabolites. Environmental Science and Pollution Research 22:9, pages 7062-7070.
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Peter Kuklenyik, Samuel E. Baker, Amanda M. Bishop, Pilar Morales-A & Antonia M. Calafat. (2013) On-line solid phase extraction-high performance liquid chromatography–isotope dilution–tandem mass spectrometry approach to quantify N,N-diethyl-m-toluamide and oxidative metabolites in urine. Analytica Chimica Acta 787, pages 267-273.
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Vicent Yusa, Xiaoyun Ye & Antonia M. Calafat. (2012) Methods for the determination of biomarkers of exposure to emerging pollutants in human specimens. TrAC Trends in Analytical Chemistry 38, pages 129-142.
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P. Calza, C. Medana, E. Raso, V. Giancotti & C. Minero. (2011) N,N-diethyl-m-toluamide transformation in river water. Science of The Total Environment.
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P.C. Das,Y. Cao,R.L. Rose,N. Cherrington,E. Hodgson,. (2008) Enzyme Induction and Cytotoxicity in Human Hepatocytes by Chlorpyrifos and N,N-Diethyl-m-toluamide (DEET). Drug Metabolism and Drug Interactions 23:3-4, pages 237-260.
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S.D. Costanzo, A.J. Watkinson, E.J. Murby, D.W. Kolpin & M.W. Sandstrom. (2007) Is there a risk associated with the insect repellent DEET (N,N-diethyl-m-toluamide) commonly found in aquatic environments?. Science of The Total Environment 384:1-3, pages 214-220.
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Walter Yu, Jeffrey M. Dener, Daniel A. Dickman, Paul Grothaus, Yun Ling, Liang Liu, Chris Havel, Kimberly Malesky, Tania Mahajan, Colin O’Brian, Emma J. Shelton, David Sperandio, Zhiwei Tong, Robert Yee & Joyce J. Mordenti. (2006) Identification of metabolites of the tryptase inhibitor CRA-9249: Observation of a metabolite derived from an unexpected hydroxylation pathway. Bioorganic & Medicinal Chemistry Letters 16:15, pages 4053-4058.
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Mark W. Sandstrom, Dana W. Kolpin, E. Michael Thurman & Steven D. Zaugg. (2009) Widespread detection of N,N ‐diethyl‐ m ‐toluamide in U.S. Streams: Comparison with concentrations of pesticides, personal care products, and other organic wastewater compounds . Environmental Toxicology and Chemistry 24:5, pages 1029-1034.
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Khawja A. Usmani, Randy L. Rose, Joyce A. Goldstein, Wesley G. Taylor, Alan A. Brimfield & Ernest Hodgson. (2002) In Vitro Human Metabolism and Interactions of Repellent N,N -Diethyl- m -Toluamide . Drug Metabolism and Disposition 30:3, pages 289-294.
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. 2001. Metabolic Maps. Metabolic Maps 288 295 .

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