Citations (40)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (8)
Toby J. Athersuch, Ian D. Wilson, Hector C. Keun & John C. Lindon. (2013) Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry. Xenobiotica 43:9, pages 792-802.
Read now
Read now
T. J. Athersuch, J. Castro-Perez, C. Rodgers, J. K. Nicholson & I. D. Wilson. (2010) UPLC-MS, HPLC-radiometric, and NMR-spectroscopic studies on the metabolic fate of 3-fluoro-[U-14C]-aniline in the bile-cannulated rat. Xenobiotica 40:7, pages 510-523.
Read now
Read now
B. Kammerer, H. Scheible, G. Zurek, M. Godejohann, K.-P. Zeller, C. H. Gleiter, W. Albrecht & S. Laufer. (2007) In vitro metabolite identification of ML3403, a 4-pyridinylimidazole-type p38 MAP kinase inhibitor by LC-Qq-TOF-MS and LC-SPE-cryo-NMR/MS. Xenobiotica 37:3, pages 280-297.
Read now
Read now
T. J. Athersuch, C. J. Duckett, J. Castro-Perez, C. Rodgers, J. K. Nicholson & I. D. Wilson. (2007) Metabolism of [14C]-5-chloro-1,3-benzodioxol-4-amine in male Wistar-derived rats following intraperitoneal administration. Xenobiotica 37:1, pages 44-58.
Read now
Read now
C. J. Duckett, J. C. Lindon, H. Walker, F. Abou-Shakra, I. D. Wilson & J. K. Nicholson. (2006) Metabolism of 3-chloro-4-fluoroaniline in rat using [14C]-radiolabelling, 19F-NMR spectroscopy, HPLC-MS/MS, HPLC-ICPMS and HPLC-NMR. Xenobiotica 36:1, pages 59-77.
Read now
Read now
F. Desmoulin, V. Gilard, M. Malet-Martino, R. Martino, C. Molina & P. Smith. (2003) Metabolism of a novel nucleoside analogue, OGT 719, in the isolated perfused rat liver model, in rats, in tumour models and in patients. Xenobiotica 33:3, pages 289-303.
Read now
Read now
G. B. Scarfe, I. D. Wilson, M. A. Warne, E. Holmes, J. K. Nicholson & J. C. Lindon. (2002) Structure-metabolism relationships of substituted anilines: prediction of N-acetylation and N-oxanilic acid formation using computational chemistry. Xenobiotica 32:4, pages 267-277.
Read now
Read now
G. B. Scarfe, J. C. Lindon, J. K. Nicholson, P. Martin, B. Wright, S. Taylor, E. Lenz & I. D. Wilson. (2000) Investigation of the metabolism of 14C/13C-practolol in rat using directly coupled radio-HPLC-NMR-MS. Xenobiotica 30:7, pages 717-729.
Read now
Read now
Articles from other publishers (32)
Marine P. M. Letertre, Patrick Giraudeau & Pascal de Tullio. (2021) Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives. Frontiers in Molecular Biosciences 8.
Crossref
Crossref
Rose M. Gathungu, Roger Kautz, Bruce S. Kristal, Susan S. Bird & Paul Vouros. (2018) The integration of LC‐MS and NMR for the analysis of low molecular weight trace analytes in complex matrices. Mass Spectrometry Reviews 39:1-2, pages 35-54.
Crossref
Crossref
Gabriele Sabbioni. (2017) Hemoglobin Adducts and Urinary Metabolites of Arylamines and Nitroarenes. Chemical Research in Toxicology 30:10, pages 1733-1766.
Crossref
Crossref
Alexander David James, Cyrille Marvalin, Alexandre Luneau, Axel Meissner & Gian Camenisch. (2017)
Comparison of
19
F NMR and
14
C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans
. Drug Metabolism and Disposition 45:8, pages 900-907.
Crossref
Crossref
Ian D. Wilson. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction
485
498
.
Abdul E. Mutlib. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics
1
31
.
Abdul Mutlib, Robert Espina, James Atherton, Jianyao Wang, Rasmy Talaat, JoAnn Scatina & Appavu Chandrasekaran. (2012)
Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (
19
F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies
. Chemical Research in Toxicology 25:3, pages 572-583.
Crossref
Crossref
Maria Victoria Silva Elipe. 2011. LC-NMR and Other Hyphenated NMR Techniques. LC-NMR and Other Hyphenated NMR Techniques
131
142
.
Helio G. Bonacorso, Liliane M.F. Porte, Jussara Navarini, Gisele R. Paim, Fábio M. Luz, Lenon M. Oliveira, Carson W. Whietan, Marcos A.P. Martins & Nilo Zanatta. (2011) Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST. Tetrahedron Letters 52:26, pages 3333-3335.
Crossref
Crossref
Abdul Mutlib, Robert Espina, Karthick Vishwanathan, Kathlene Babalola, Zecheng Chen, Christoph Dehnhardt, Aranapakam Venkatesan, Tarek Mansour, Inder Chaudhary, Rasmy Talaat & JoAnn Scatina. (2011) Application of Quantitative NMR in Pharmacological Evaluation of Biologically Generated Metabolites: Implications in Drug Discovery. Drug Metabolism and Disposition 39:1, pages 106-116.
Crossref
Crossref
Ian D. Wilson. 2011. Metabolic Profiling. Metabolic Profiling
173
190
.
Angus N. R. Nedderman & Don K. Walker. 2011. Pharmacokinetics in Drug Development. Pharmacokinetics in Drug Development
131
143
.
Peter J Mutch, Gordon J Dear & Issy M Ismail. (2001) Formation of a defluorinated metabolite of a quinoxaline antiviral drug catalysed by human cytochrome P450 1A2. Journal of Pharmacy and Pharmacology 53:3, pages 403-408.
Crossref
Crossref
Don Walker, Joe Brady, Deepak Dalvie, John Davis, Martin Dowty, J. Neil Duncan, Angus Nedderman, R. Scott Obach & Pat Wright. (2009) A Holistic Strategy for Characterizing the Safety of Metabolites through Drug Discovery and Development. Chemical Research in Toxicology 22:10, pages 1653-1662.
Crossref
Crossref
Angus N. R. Nedderman. (2009) Metabolites in safety testing: metabolite identification strategies in discovery and development. Biopharmaceutics & Drug Disposition 30:4, pages 153-162.
Crossref
Crossref
I.D. Wilson. 2008. NMR Spectroscopy in Pharmaceutical Analysis. NMR Spectroscopy in Pharmaceutical Analysis
449
469
.
Ian D. Wilson & Udo A.Th. Brinkman. (2007) Hype and hypernation: multiple hyphenation of column liquid chromatography and spectroscopy. TrAC Trends in Analytical Chemistry 26:9, pages 847-854.
Crossref
Crossref
Chandra Prakash, Christopher L. Shaffer & Angus Nedderman. (2007) Analytical strategies for identifying drug metabolites. Mass Spectrometry Reviews 26:3, pages 340-369.
Crossref
Crossref
Zheng Yang. (2006) Online hyphenated liquid chromatography–nuclear magnetic resonance spectroscopy–mass spectrometry for drug metabolite and nature product analysis. Journal of Pharmaceutical and Biomedical Analysis 40:3, pages 516-527.
Crossref
Crossref
Helena Kovacs, Detlef Moskau & Manfred Spraul. (2005) Cryogenically cooled probes—a leap in NMR technology. Progress in Nuclear Magnetic Resonance Spectroscopy 46:2-3, pages 131-155.
Crossref
Crossref
Maria Victoria Silva Elipe. (2003) Advantages and disadvantages of nuclear magnetic resonance spectroscopy as a hyphenated technique. Analytica Chimica Acta 497:1-2, pages 1-25.
Crossref
Crossref
John C. Lindon, Nigel J.C. Bailey, Jeremy K. Nicholson & Ian D. Wilson. 2003. Bioanalytical Separations. Bioanalytical Separations
293
329
.
M Tugnait, E.M Lenz, M Hofmann, M Spraul, I.D Wilson, J.C Lindon & J.K Nicholson. (2003) The metabolism of 2-trifluormethylaniline and its acetanilide in the rat by 19F NMR monitored enzyme hydrolysis and 1H/19F HPLC-NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis 30:5, pages 1561-1574.
Crossref
Crossref
Donghui Bao, Venkataraman Thanabal & William F Pool. (2002) Determination of tacrine metabolites in microsomal incubate by high performance liquid chromatography–nuclear magnetic resonance/mass spectrometry with a column trapping system. Journal of Pharmaceutical and Biomedical Analysis 28:1, pages 23-30.
Crossref
Crossref
Dave Louden, Alan Handley, Rene Lafont, Steve Taylor, Ian Sinclair, Eva Lenz, Timothy Orton & Ian D. Wilson. (2001)
HPLC Analysis of Ecdysteroids in Plant Extracts Using Superheated Deuterium Oxide with Multiple On-Line Spectroscopic Analysis (UV, IR,
1
H NMR, and MS)
. Analytical Chemistry 74:1, pages 288-294.
Crossref
Crossref
Eva Lenz, Steve Taylor, Craig Collins, Ian D Wilson, Dave Louden & Alan Handley. (2002) Flow injection analysis with multiple on-line spectroscopic analysis (UV, IR, 1H-NMR and MS). Journal of Pharmaceutical and Biomedical Analysis 27:1-2, pages 191-200.
Crossref
Crossref
B Kevin ParkNeil R KitteringhamPaul M O'Neill. (2001) Metabolism of Fluorine-Containing Drugs. Annual Review of Pharmacology and Toxicology 41:1, pages 443-470.
Crossref
Crossref
Dave Louden, Alan Handley, Steve Taylor, Eva Lenz, Steve Miller, Ian D Wilson, Ashley Sage & R Lafont. (2001) Spectroscopic characterisation and identification of ecdysteroids using high-performance liquid chromatography combined with on-line UV–diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time of flight mass spectrometry. Journal of Chromatography A 910:2, pages 237-246.
Crossref
Crossref
Graeme B. Scarfe, Edward Clayton, Ian D. Wilson & Jeremy K. Nicholson. (2000) Identification and quantification of metabolites of 2,3,5,6-tetrafluoro-4-trifluoromethylaniline in rat urine using 19F nuclear magnetic resonance spectroscopy, high-performance liquid chromatography–nuclear magnetic resonance spectroscopy and high-performance liquid chromatography–mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 748:1, pages 311-319.
Crossref
Crossref
John C Lindon, Jeremy K Nicholson & Ian D Wilson. (2000) Directly coupled HPLC–NMR and HPLC–NMR–MS in pharmaceutical research and development. Journal of Chromatography B: Biomedical Sciences and Applications 748:1, pages 233-258.
Crossref
Crossref
I.D Wilson. (2000) Multiple hyphenation of liquid chromatography with nuclear magnetic resonance spectroscopy, mass spectrometry and beyond. Journal of Chromatography A 892:1-2, pages 315-327.
Crossref
Crossref
Arron S.L. Xu, Thomas L. Luntz, Jeffrey M. Macdonald, Hiroshi Kubota, Edward Hsu, Robert E. London & Lola M. Reid. 2000. Principles of Tissue Engineering. Principles of Tissue Engineering
559
598a
.