Multifunctional 1,10-phenanthroline derivative and its metal complexes as an anti-Alzheimer’s agent: structure-based drug design, synthesis, characterization and pharmacological studies

E. H. Edinsha Gladisa Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamilnadu, India;b Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, Tamilnadu, India

K. Nagashria Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamilnadu, IndiaCorrespondence[email protected]

A. Sumana Department of Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamilnadu, India

J. Josephb Department of Chemistry, Noorul Islam Centre for Higher Education, Kumaracoil, Tamilnadu, India

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Juan D. Sánchez, Andrés R. Alcántara, Juan F. González & José María Sánchez-Montero. (2023) Advances in the discovery of heterocyclic-based drugs against Alzheimer’s disease. Expert Opinion on Drug Discovery 18:12, pages 1413-1428.
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E. H. Edinsha Gladis, K. Nagashri, M. Anisha & J. Joseph. (2023) Synthesis, characterisation, DNA binding, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities and molecular docking studies of metal(II) complexes with 1,10-phenanthroline scaffold. Journal of Biomolecular Structure and Dynamics 41:11, pages 5067-5085.
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E. H. Edinsha Gladis, K. Nagashri & A. Krishnendu. (2022) Synthesis, structural elucidation, DNA binding, cleavage, AChE and BuChE cholinesterase efficiencies of metal complexes with 1,10-phenanthroline scaffold. Nucleosides, Nucleotides & Nucleic Acids 41:3, pages 285-313.
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B. Ebenezer & K. Nagashri. (2021) Synthesis and in vitro biochemical properties, DNA binding and DNA cleavage ability of copper complexes of hydroxyflavone derivatives of novel organosulfur compounds as therapeutic agent. Nucleosides, Nucleotides & Nucleic Acids 40:12, pages 1159-1197.
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Tarana Umar, Rampratap Meena, Mustehasan, Pawan Kumar & Asim Ali Khan. (2022) Recent updates in the development of small molecules as potential clinical candidates for Alzheimer's disease: A review. Chemical Biology & Drug Design 100:5, pages 674-681.
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Amalia Barmpa, Antonios G. Hatzidimitriou & George Psomas. (2021) Copper(II) complexes with meclofenamate ligands: Structure, interaction with DNA and albumins, antioxidant and anticholinergic activity. Journal of Inorganic Biochemistry 217, pages 111357.
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Multifunctional 1,10-phenanthroline derivative and its metal complexes as an anti-Alzheimer’s agent: structure-based drug design, synthesis, characterization and pharmacological studies

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Multifunctional 1,10-phenanthroline derivative and its metal complexes as an anti-Alzheimer’s agent: structure-based drug design, synthesis, characterization and pharmacological studies

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