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Original Articles

PHYSIOLOGICALLY BASED MODELING OF THE MAXIMAL EFFECT OF METABOLIC INTERACTIONS ON THE KINETICS OF COMPONENTS OF COMPLEX CHEMICAL MIXTURES

Pages 209-223 | Published online: 30 Nov 2010

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Frédéric Cosnier, Hervé Nunge, Élodie Bonfanti, Stéphane Grossmann, Anne-Marie Lambert-Xollin, Samuel Muller, Sylvie Sébillaud, Aurélie Thomas, Laurent Gaté & Pierre Campo. (2018) Toluene and methylethylketone: effect of combined exposure on their metabolism in rat. Xenobiotica 48:7, pages 684-694.
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Lorenz R. Rhomberg, David B. Mayfield, Julie E. Goodman, Eric L. Butler, Marc A. Nascarella & Daniel R. Williams. (2015) Quantitative cancer risk assessment for occupational exposures to asphalt fumes during built-up roofing asphalt (BURA) operations. Critical Reviews in Toxicology 45:10, pages 873-918.
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M. Moiz Mumtaz, Meredith Ray, Susan R. Crowell, Deborah Keys, Jeffrey Fisher & Patricia Ruiz. (2012) Translational Research to Develop a Human PBPK Models Tool Kit—Volatile Organic Compounds (VOCs). Journal of Toxicology and Environmental Health, Part A 75:1, pages 6-24.
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Ahmad Aakash, Ramsha Kulsoom, Saba Khan, Musab Saeed Siddiqui & Deedar Nabi. (2023) Novel Models for Accurate Estimation of Air–Blood Partitioning: Applications to Individual Compounds and Complex Mixtures of Neutral Organic Compounds. Journal of Chemical Information and Modeling 63:22, pages 7056-7066.
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Hana R. Pohl, Melanie C. Buser, Patricia Ruiz & Moiz M. Mumtaz. 2003. Patty's Toxicology. Patty's Toxicology 1 33 .
Carina Ladeira, Goran Gajski, Márcia Meneses, Marko Gerić & Susana Viegas. (2020) The genotoxicity of an organic solvent mixture: A human biomonitoring study and translation of a real-scenario exposure to in vitro. Regulatory Toxicology and Pharmacology 116, pages 104726.
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Dimosthenis Α. Sarigiannis, Spyros P. Karakitsios, Evangelos Handakas & Alberto Gotti. (2020) Development of a generic lifelong physiologically based biokinetic model for exposome studies. Environmental Research 185, pages 109307.
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Patricia Ruiz, Claude Emond, Eva D McLanahan, Shivanjali Joshi-Barr & Moiz Mumtaz. (2020) Exploring Mechanistic Toxicity of Mixtures Using PBPK Modeling and Computational Systems Biology. Toxicological Sciences 174:1, pages 38-50.
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Honesty Tohon, Mathieu Valcke & Sami Haddad. (2019) An assessment of the impact of multi‐route co‐exposures on human variability in toxicokinetics: A case study with binary and quaternary mixtures of volatile drinking water contaminants. Journal of Applied Toxicology 39:7, pages 974-991.
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Dimosthenis A. Sarigiannis, Spyros P. Karakitsios, Evangelos Handakas, Krystalia Papadaki, Dimitris Chapizanis & Alberto Gotti. 2018. Applying Big Data Analytics in Bioinformatics and Medicine. Applying Big Data Analytics in Bioinformatics and Medicine 115 144 .
Sami Haddad. 2018. Chemical Mixtures and Combined Chemical and Nonchemical Stressors. Chemical Mixtures and Combined Chemical and Nonchemical Stressors 307 333 .
Micah N. Jasper, Sheppard A. Martin, Wendy M. Oshiro, Jermaine Ford, Philip J. Bushnell & Hisham El-Masri. (2016) Application of Biologically Based Lumping To Investigate the Toxicokinetic Interactions of a Complex Gasoline Mixture. Environmental Science & Technology 50:6, pages 3231-3238.
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David W. Herr, Danielle L. Freeborn, Laura Degn, Sheppard A. Martin, Jayna Ortenzio, Lara Pantlin, Charles W. Hamm & William K. Boyes. (2016) Neurophysiological assessment of auditory, peripheral nerve, somatosensory, and visual system function after developmental exposure to gasoline, E15, and E85 vapors. Neurotoxicology and Teratology 54, pages 78-88.
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. 2010. Mixture Toxicity. Mixture Toxicity 229 269 .
Paul S. Price. 2010. Principles and Practice of Mixtures Toxicology. Principles and Practice of Mixtures Toxicology 377 399 .
Toshiaki Yoshida. (2010) Estimation of absorption of aromatic hydrocarbons diffusing from interior materials in automobile cabins by inhalation toxicokinetic analysis in rats. Journal of Applied Toxicology 30:6, pages 525-535.
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Sami Haddad, Robert Tardif, Jonathan Boyd & Kannan Krishnan. 2010. Quantitative Modeling in Toxicology. Quantitative Modeling in Toxicology 83 105 .
Lesa L. Aylward, Sean M. Hays, Michelle Gagné & Kannan Krishnan. (2009) Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP). Regulatory Toxicology and Pharmacology 55:3, pages 259-267.
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Lesa L. Aylward, Sean M. Hays, Michelle Gagné & Kannan Krishnan. (2009) Derivation of Biomonitoring Equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7). Regulatory Toxicology and Pharmacology 55:3, pages 249-258.
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Kannan Krishnan, Sastry Isukapalli & Jonathan Boyd. 2009. General, Applied and Systems Toxicology. General, Applied and Systems Toxicology.
Jane C. Caldwell, Nagalakshmi Keshava & Marina V. Evans. (2007) Difficulty of mode of action determination for trichloroethylene: An example of complex interactions of metabolites and other chemical exposures. Environmental and Molecular Mutagenesis 49:2, pages 142-154.
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L.S. McCarty & C.J. Borgert. (2006) Review of the toxicity of chemical mixtures: Theory, policy, and regulatory practice. Regulatory Toxicology and Pharmacology 45:2, pages 119-143.
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Sathanandam S. Anand & Harihara M. Mehendale. (2004) Liver regeneration: a critical toxicodynamic response in predictive toxicology. Environmental Toxicology and Pharmacology 18:2, pages 149-160.
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Raymond S.H. Yang, Hisham A. El-Masri, Russell S. Thomas, Ivan D. Dobrev, James E. DennisonJr.Jr., Dong-Soon Bae, Julie A. Campain, Kai H. Liao, Brad Reisfeld, Melvin E. Andersen & Moiz Mumtaz. (2004) Chemical mixture toxicology: from descriptive to mechanistic, and going on to in silico toxicology. Environmental Toxicology and Pharmacology 18:2, pages 65-81.
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George D. Loizou & Martin Spendiff. (2004) A human PBPK model for ethanol describing inhibition of gastric motility. The Histochemical Journal 35:7, pages 687-696.
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