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Original Articles

PHARMACOKINETICS OF BENZO[a]PYRENE IN THE RAT

Pages 507-530 | Published online: 30 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Jerry Campbell, Allison Franzen, Cynthia Van Landingham, Michael Lumpkin, Susan Crowell, Clive Meredith, Anne Loccisano, Robinan Gentry & Harvey Clewell. (2016) Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling. Inhalation Toxicology 28:11, pages 520-535.
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Marjory Moreau, Pierre Ayotte & Michèle Bouchard. (2015) Kinetics of Diol and Hydroxybenzo[a]pyrene Metabolites in Relation to DNA Adduct Formation and Gene Expression in Rats. Journal of Toxicology and Environmental Health, Part A 78:12, pages 725-746.
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Marjory Moreau, Nathalie Ouellet, Pierre Ayotte & Michèle Bouchard. (2015) Effects of Intravenous Benzo[a]Pyrene Dose Administration on Levels of Exposure Biomarkers, DNA Adducts, and Gene Expression in Rats. Journal of Toxicology and Environmental Health, Part A 78:3, pages 166-184.
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Ivy Moffat, Nikolai L. Chepelev, Sarah Labib, Julie Bourdon-Lacombe, Byron Kuo, Julie K. Buick, France Lemieux, Andrew Williams, Sabina Halappanavar, Amal I Malik, Mirjam Luijten, Jiri Aubrecht, Daniel R. Hyduke, Albert J. Fornace$suffix/text()$suffix/text(), Carol D. Swartz, Leslie Recio & Carole L. Yauk. (2015) Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water. Critical Reviews in Toxicology 45:1, pages 1-43.
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Kelly L Harris, Leah D Banks, Jane A Mantey, Ashley C Huderson & Aramandla Ramesh. (2013) Bioaccessibility of polycyclic aromatic hydrocarbons: relevance to toxicity and carcinogenesis. Expert Opinion on Drug Metabolism & Toxicology 9:11, pages 1465-1480.
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Marwa E. Elsherbiny & Dion R. Brocks. (2011) The ability of polycyclic aromatic hydrocarbons to alter physiological factors underlying drug disposition. Drug Metabolism Reviews 43:4, pages 457-475.
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DeacqunitaL. Diggs, AshleyC. Huderson, KellyL. Harris, JeremyN. Myers, LeahD. Banks, PerumallaV. Rekhadevi, MohammadS. Niaz & Aramandla Ramesh. (2011) Polycyclic Aromatic Hydrocarbons and Digestive Tract Cancers: A Perspective. Journal of Environmental Science and Health, Part C 29:4, pages 324-357.
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Ashley C. Huderson, Deacqunita L. Harris, Mohammad S. Niaz & Aramandla Ramesh. (2010) Effect of benzo(a)pyrene exposure on fluoranthene metabolism by mouse adipose tissue microsomes. Toxicology Mechanisms and Methods 20:2, pages 53-58.
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Dianxiu Cao, Chi Ho Yoon, Beom Soo Shin, Chul Hwan Kim, Eun Seok Park & Sun Dong Yoo. (2005) Effects of Aloe, Aloesin, or Propolis on the Pharmacokinetics of Benzo[a]Pyrene and 3-OH-Benzo[a]Pyrene in Rats. Journal of Toxicology and Environmental Health, Part A 68:23-24, pages 2227-2238.
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G. L. Qiao & J. E. Riviere. (2002) SYSTEMIC UPTAKE AND CUTANEOUS DISPOSITION OF PENTACHLOROPHENOL IN A SEQUENTIAL EXPOSURE SCENARIO: EFFECTS OF SKIN PREEXPOSURE TO BENZO[a]PYRENE. Journal of Toxicology and Environmental Health, Part A 65:18, pages 1307-1331.
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Articles from other publishers (34)

Asit Kumar, Namita Sinha, Sunitha Kodidela, Lina Zhou, Udai P. Singh & Santosh Kumar. (2022) Effect of benzo(a)pyrene on oxidative stress and inflammatory mediators in astrocytes and HIV-infected macrophages. PLOS ONE 17:10, pages e0275874.
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Yung‐Shan Lee, Talia R. Cole, Manpreet S. Jhutty, Mark A. Cantu, Beatrice Chee, Stephanie C. Stelmaschuk & Frank A. P. C. Gobas. (2022) Bioaccumulation Screening of Neutral Hydrophobic Organic Chemicals in Air‐Breathing Organisms Using In Vitro Rat Liver S9 Biotransformation Assays. Environmental Toxicology and Chemistry 41:10, pages 2565-2579.
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Aramandla Ramesh, Kenneth J. Harris & Anthony E. Archibong. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 759 778 .
Yung‐Shan Lee, Justin C. Lo, S.Victoria Otton, Margo M. Moore, Chris J. Kennedy & Frank A.P.C. Gobas. (2017) In vitro to in vivo extrapolation of biotransformation rates for assessing bioaccumulation of hydrophobic organic chemicals in mammals. Environmental Toxicology and Chemistry 36:7, pages 1934-1946.
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Jordan N. Smith, Denis Mehinagic, Subhasree Nag, Susan R. Crowell & Richard A. Corley. (2017) In vitro metabolism of benzo[a]pyrene-7,8-dihydrodiol and dibenzo[def,p]chrysene-11,12 diol in rodent and human hepatic microsomes. Toxicology Letters 269, pages 23-32.
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Aramandla Ramesh, Kenneth J. Harris & Anthony E. Archibong. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 745 763 .
Niels E. Olesen, Vasiliki Vana & René Holm. (2016) Does the Digestibility of Cyclodextrins Influence the In Vivo Absorption of Benzo[a]pyrene in Rats?. Journal of Pharmaceutical Sciences 105:9, pages 2698-2702.
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Rachel E. Peters, Kyle James, Mark Cave, Mark Wickstrom & Steven D. Siciliano. (2016) Is received dose from ingested soil independent of soil PAH concentrations?—Animal model results. Environmental Toxicology and Chemistry 35:9, pages 2261-2269.
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Marjory Moreau & Michèle Bouchard. (2014) Comparison of the kinetics of various biomarkers of benzo[ a ]pyrene exposure following different routes of entry in rats . Journal of Applied Toxicology 35:7, pages 781-790.
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Jingyu Guo, Yi Xu, Weiwei Ji, Lele Song, Cheng Dai & Lixing Zhan. (2015) Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling. Toxicology Letters 234:3, pages 201-210.
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Nikolai L. Chepelev, Ivy D. Moffat, Wayne J. Bowers & Carole L. Yauk. (2015) Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment. Mutation Research/Reviews in Mutation Research 764, pages 64-89.
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Rachel E. Peters, Mark Wickstrom & Steven D. Siciliano. (2015) The bioavailability of polycyclic aromatic hydrocarbons from different dose media after single and sub-chronic exposure in juvenile swine. Science of The Total Environment 506-507, pages 308-314.
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Roberto Heredia-Ortiz & Michèle Bouchard. (2013) Understanding the linked kinetics of benzo(a)pyrene and 3-hydroxybenzo(a)pyrene biomarker of exposure using physiologically-based pharmacokinetic modelling in rats. Journal of Pharmacokinetics and Pharmacodynamics 40:6, pages 669-682.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 243 249 .
Hongmei Zhang, Jisheng Nie, Xin Li & Qiao Niu. (2013) Association of Aryl Hydrocarbon Receptor Gene Polymorphism With the Neurobehavioral Function and Autonomic Nervous System Function Changes Induced by Benzo[a]Pyrene Exposure in Coke Oven Workers. Journal of Occupational & Environmental Medicine 55:3, pages 265-271.
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. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 7 .
Susan Ritger Crowell, Shantu G. Amin, Kim A. Anderson, Gowdahalli Krishnegowda, Arun K. Sharma, Jolen J. Soelberg, David E. Williams & Richard A. Corley. (2011) Preliminary physiologically based pharmacokinetic models for benzo[a]pyrene and dibenzo[def,p]chrysene in rodents. Toxicology and Applied Pharmacology 257:3, pages 365-376.
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Nathalie Grova, Guillaume Salquèbre, Henri Schroeder & Brice M. R. Appenzeller. (2011) Determination of PAHs and OH-PAHs in Rat Brain by Gas Chromatography Tandem (Triple Quadrupole) Mass Spectrometry. Chemical Research in Toxicology 24:10, pages 1653-1667.
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Roberto Heredia-Ortiz, Michèle Bouchard, Caroline Marie-Desvergne, Claude Viau & Anne Maître. (2011) Modeling of the Internal Kinetics of Benzo(a)pyrene and 3-Hydroxybenzo(a)pyrene Biomarker from Rat Data. Toxicological Sciences 122:2, pages 275-287.
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J. M. Villalba, A. J. Barbero, R. Diaz‐Sierra, E. Arribas, M. J. Garcia‐Meseguer, F. Garcia‐Sevilla, M. Garcia‐Moreno, J. A. Vidal De Labra & R. Varon. (2010) Computerized evaluation of mean residence times in multicompartmental linear system and pharmacokinetics. Journal of Computational Chemistry 32:5, pages 915-931.
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Yinyin Xia, Shuqun Cheng, Junlin He, Xueqing Liu, Yan Tang, Haiyan Yuan, Lijun He, Tao Lu, Baijie Tu & Yingxiong Wang. (2011) Effects of subchronic exposure to benzo[a]pyrene (B[a]P) on learning and memory, and neurotransmitters in male Sprague–Dawley rat. NeuroToxicology 32:2, pages 188-198.
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Eugenia Murawska-CiaŁowicz, Zbigniew Jethon, Jan Magdalan, Lidia Januszewska, Marzena Podhorska-OkoŁów, Marcin Zawadzki, Tomasz Sozański & Piotr Dzięgiel. (2011) Effects of melatonin on lipid peroxidation and antioxidative enzyme activities in the liver, kidneys and brain of rats administered with benzo(a)pyrene. Experimental and Toxicologic Pathology 63:1-2, pages 97-103.
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Darryl B. Hood, Aramandla Ramesh, Sanika Chirwa, Habibeh Khoshbouei & Anthony E. Archibong. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 593 606 .
Aramandla Ramesh & Anthony E. Archibong. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 577 591 .
S.Y. Park, S. Phark, M. Lee, J.Y. Lim & D. Sul. (2010) Anti-oxidative and anti-inflammatory activities of placental extracts in benzo[a]pyrene-exposed rats. Placenta 31:10, pages 873-879.
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Caroline Marie, Michèle Bouchard, Roberto Heredia‐Ortiz, Claude Viau & Anne Maître. (2010) A toxicokinetic study to elucidate 3‐hydroxybenzo(a)pyrene atypical urinary excretion profile following intravenous injection of benzo(a)pyrene in rats. Journal of Applied Toxicology 30:5, pages 402-410.
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Monique M. McCallister, Mark Maguire, Aramandla Ramesh, Qiao Aimin, Sheng Liu, Habibeh Khoshbouei, Michael Aschner, Ford F. Ebner & Darryl B. Hood. (2008) Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. NeuroToxicology 29:5, pages 846-854.
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Hong‐Mei Zhang, Ji‐Sheng Nie, Fang Wang, Ying‐Tao Shi, Ling Zhang, Andrea Antonucci, Hui‐Jun Liu, Jing Wang, Jie Zhao, Qin‐Li Zhang, Lin‐Ping Wang, Jing Song, Cui‐E Xue, Mario Di Gioacchino & Qiao Niu. (2008) Effects of Benzo[a]pyrene on Autonomic Nervous System of Coke Oven Workers. Journal of Occupational Health 50:4, pages 308-316.
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Jacqui Detmar, Tatiana Rabaglino, Yoshinari Taniuchi, Jaymin Oh, Beth M. Acton, Adalberto Benito, Gabriel Nunez & Andrea Jurisicova. (2006) Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax. Apoptosis 11:8, pages 1413-1425.
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M. Ciganek & J. Neca. (2006) Polycyclic aromatic hydrocarbons in porcine and bovine organs and tissues. Veterinární medicína 51:5, pages 239-247.
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Goran Westerberg & Lars Wiklund. (2005) β‐Cyclodextrin Reduces Bioavailability of Orally Administered [3H]Benzo[a]pyrene in the Rat. Journal of Pharmaceutical Sciences 94:1, pages 114-119.
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Charles A. Brandt, James M. Becker & Augusto Porta. (2009) Distribution of polycyclic aromatic hydrocarbons in soils and terrestrial biota after a spill of crude oil in Trecate, Italy. Environmental Toxicology and Chemistry 21:8, pages 1638-1643.
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Aramandla Ramesh, Frank Inyang, Darryl B. Hood, Anthony E. Archibong, Maurice E. Knuckles & Alfred M. Nyanda. (2001) Metabolism, bioavailability, and toxicokinetics of Benzo(α)pyrenein F-344 rats following oral administration. Experimental and Toxicologic Pathology 53:4, pages 275-290.
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Ronald Eisler. 2000. Handbook of Chemical Risk Assessment. Handbook of Chemical Risk Assessment.

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