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Original Articles

THE PPAR ACTIVATOR DOCOSAHEXAENOIC ACID PREVENTS ACETAMINOPHEN HEPATOTOXICITY IN MALE CD-1 MICE

Pages 171-186 | Published online: 30 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

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Jin Tae Hong, Myung Koo Lee, Ki Sook Park, Kyung Mi Jung, Rhee Da Lee, Hai Kwan Jung, Kui Lae Park, Ki Hwa Yang & Soo Youn Chung. (2002) INHIBITORY EFFECT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONIST ON OCHRATOXIN A-INDUCED CYTOTOXICITY AND ACTIVATION OF TRANSCRIPTION FACTORS IN CULTURED RAT EMBRYONIC MIDBRAIN CELLS. Journal of Toxicology and Environmental Health, Part A 65:5-6, pages 407-418.
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Chuan Chen, Gayle E. Hennig, Denis J. McCann & José E. Manautou. (2000) Effects of clofibrate and indocyanine green on the hepatobiliary disposition of acetaminophen and its metabolites in male CD-1 mice. Xenobiotica 30:11, pages 1019-1032.
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Articles from other publishers (15)

Marcha CT. Verheijen, Matthew J. Meier, Juan Ochoteco Asensio, Timothy W. Gant, Weida Tong, Carole L. Yauk & Florian Caiment. (2022) R-ODAF: Omics data analysis framework for regulatory application. Regulatory Toxicology and Pharmacology 131, pages 105143.
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David S Umbaugh, Anup Ramachandran & Hartmut Jaeschke. (2021) Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing. Toxicological Sciences 182:2, pages 327-345.
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Mingzhu Yan, Yazhen Huo, Shutao Yin & Hongbo Hu. (2018) Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions. Redox Biology 17, pages 274-283.
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Masaaki Miyata, Yuichi Kinoshita, Kouhei Shinno, Yoshimasa Sugiura & Kazuki Harada. (2016) Hepatic n-3/n-6 polyunsaturated fatty acid shift improves hepatic steatosis in farnesoid X receptor-null mice. Fisheries Science 82:3, pages 529-536.
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William M. Lee. 2015. Yamada' s Textbook of Gastroenterology. Yamada' s Textbook of Gastroenterology 1958 1972 .
Vincent E. de Meijer, Brian T. Kalish, Jonathan A. Meisel, Hau D. Le & Mark Puder. (2012) Dietary Fish Oil Aggravates Paracetamol-Induced Liver Injury in Mice. Journal of Parenteral and Enteral Nutrition 37:2, pages 268-273.
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Sara Borniquel, Cecilia Jädert & Jon O. Lundberg. (2012) Dietary Conjugated Linoleic Acid Activates PPARγ and the Intestinal Trefoil Factor in SW480 Cells and Mice with Dextran Sulfate Sodium-Induced Colitis3. The Journal of Nutrition 142:12, pages 2135-2140.
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Hasan Türkez, Fatime Geyikoglu & Mokhtar Ibrahim Yousef. (2011) Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo- p -dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver . Toxicology and Industrial Health 28:8, pages 687-696.
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ME El-Mesery, MM Al-Gayyar, HA Salem, MM Darweish & AM El-Mowafy. (2009) Chemopreventive and renal protective effects for docosahexaenoic acid (DHA): implications of CRP and lipid peroxides. Cell Division 4:1.
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Hsi-Hsien ChenTzen-Wen ChenHeng Lin. (2009) Prostacyclin-induced peroxisome proliferator-activated receptor-α translocation attenuates NF-κB and TNF-α activation after renal ischemia-reperfusion injury. American Journal of Physiology-Renal Physiology 297:4, pages F1109-F1118.
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Chi Chen, Kristopher W. Krausz, Yatrik M. Shah, Jeffrey R. Idle & Frank J. Gonzalez. (2009) Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid β-Oxidation through the Suppression of PPARα Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity. Chemical Research in Toxicology 22:4, pages 699-707.
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Jeffrey D. Coleman, K. Sandeep Prabhu, Jerry T. Thompson, P. Sreenivasula Reddy, Jeffrey M. Peters, Blake R. Peterson, C. Channa Reddy & John P. Vanden Heuvel. (2007) The oxidative stress mediator 4-hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ). Free Radical Biology and Medicine 42:8, pages 1155-1164.
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James M. Harper, Adam B. Salmon, Yayi Chang, Michael Bonkowski, Andrzej Bartke & Richard A. Miller. (2006) Stress resistance and aging: Influence of genes and nutrition. Mechanisms of Ageing and Development 127:8, pages 687-694.
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Linda M Arterburn, Eileen Bailey Hall & Harry Oken. (2006) Distribution, interconversion, and dose response of n−3 fatty acids in humans. The American Journal of Clinical Nutrition 83:6, pages 1467S-1476S.
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Chuan Chen, Gayle E. Hennig, Herbert E. Whiteley & José E. Manautou. (2002) Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: Role of catalase induction. Journal of Biochemical and Molecular Toxicology 16:5, pages 227-234.
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