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Research Article

A Comparison of neuroprotective efficacy of newly developed oximes (K203, K206) and commonly used oximes (obidoxime, HI-6) in tabun-poisoned rats

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Pages 128-138 | Accepted 03 Nov 2008, Published online: 01 Apr 2009

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Read on this site (5)

Jiri Kassa, Jan Misik, Jana Hatlapatkova & Jana Zdarova Karasova. (2017) A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats. Toxicology Mechanisms and Methods 27:3, pages 236-243.
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Jiri Kassa, Jana Zdarova Karasova & Sandra Tesarova. (2011) A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats. Drug and Chemical Toxicology 34:3, pages 233-239.
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Jiri Kassa, Jana Zdarova Karasova, Ruzena Pavlikova, Kamil Musilek, Kamil Kuca, Jiri Bajgar & Young-Sik Jung. (2011) A comparison of reactivating and therapeutic efficacy of bispyridinium acetylcholinesterase reactivator KR-22934 with the oxime K203 and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology Mechanisms and Methods 21:3, pages 241-245.
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Jiri Kassa, Jana Zdarova Karasova, Sandra Tesarova, Kamil Kuca & Kamil Musilek. (2010) A comparison of the ability of newly-developed bispyridinium oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) to counteract the acute neurotoxicity of soman in rats. Toxicology Mechanisms and Methods 20:8, pages 445-451.
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Jiri Kassa, Jana Zdarova Karasova, Filip Caisberger & Jiri Bajgar. (2009) The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice. Toxicology Mechanisms and Methods 19:9, pages 547-551.
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Articles from other publishers (12)

Huba Kalász, Gellért Karvaly, Ferenc Szimrók, Dóra Szabó, Márton Milánkovits, András Keglevich, Jennifer Adeghate, Ferenc Darvas, Kamil Kuca, Kamil Musilek & Kornélia Tekes. (2020) Pharmacokinetics of a Mono-pyridinium-mono-aldoxime (K-347), a Potential Antidote in Organophosphate Poisoning. The Open Medicinal Chemistry Journal 14:1, pages 99-107.
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Lukas Gorecki, Ondrej Soukup, Tomas Kucera, David Malinak, Daniel Jun, Kamil Kuca, Kamil Musilek & Jan Korabecny. (2018) Oxime K203: a drug candidate for the treatment of tabun intoxication. Archives of Toxicology 93:3, pages 673-691.
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Jiri Kassa, Jan Misik, Jana Hatlapatkova, Jana Zdarova Karasova, Vendula Sepsova, Filip Caisberger & Jaroslav Pejchal. (2017) The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats—A Comparison with Trimedoxime and the Oxime K203. Molecules 22:7, pages 1152.
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Jiri Kassa, Jan Misik & Jana Zdarova Karasova. (2015) Neuroprotective efficacy of newly developed oximes in comparison with currently available oximes in tabun-poisoned rats. Journal of Applied Biomedicine 13:1, pages 39-46.
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H. Kalász, S. M. Nurulain, G. Veress, S. Antus, F. Darvas, E. Adeghate, A. Adem, F. Hashemi & K. Tekes. (2014) Mini review on blood–brain barrier penetration of pyridinium aldoximes. Journal of Applied Toxicology 35:2, pages 116-123.
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Jiří Kassa, Jana Žďárová Karasová, Kamil Kuča, Kamil Musílek & Young-Sik Jung. (2014) Comparison of the neuroprotective effects of a novel bispyridinium oxime KR-22934 with the oxime K203 and obidoxime in tabun-poisoned male rats. Journal of Applied Biomedicine 12:2, pages 111-117.
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Jiri Kassa, Jan Misik & Jana Z. Karasova. (2013) Evaluation of the Potency of Two Novel Bispyridinium Oximes ( K 456, K 458) in Comparison with Oxime K 203 and Trimedoxime to Counteract Tabun‐Induced Neurotoxicity in Rats . Basic & Clinical Pharmacology & Toxicology 113:3, pages 201-208.
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Jiří Bajgar & Jiří Kassa. (2012) FROM THE RESEARCH OF CHOLINESTERASE REACTIVATORS TO THE EFFECTIVE THERAPY OF ORGANOPHOSPHATE/NERVE AGENT POISONING. Military Medical Science Letters 81:4, pages 164-170.
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Jiri Kassa, Jan Misik & Jana Zdarova Karasova. (2012) A Comparison of the Potency of a Novel Bispyridinium Oxime K203 and currently available Oximes (Obidoxime, HI ‐6) to Counteract the Acute Neurotoxicity of Sarin in Rats . Basic & Clinical Pharmacology & Toxicology 111:5, pages 333-338.
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Kamil Musilek, Martin Dolezal, Frank Gunn‐Moore & Kamil Kuca. (2011) Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides. Medicinal Research Reviews 31:4, pages 548-575.
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Jiří Kassa & Jana Žďárová Karasová. (2011) A COMPARISON OF THE NEUROPROTECTIVE EFFICACY OF INDIVIDUAL OXIMES (HI-6, TRIMEDOXIME, K203) AND THEIR MIXTURES (HI-6 + TRIMEDOXIME, HI-6 + K203) IN CYCLOSARIN-POISONED RATS. Military Medical Science Letters 80:1, pages 12-20.
Crossref
Jiří Kassa, Jana Žďárová Karasová & Sandra Tesařová. (2009) Evaluation of the neuroprotective efficacy of individual oxime (HI-6) and oxime mixtures (HI-6 + trimedoxime, HI-6 + K203) in tabun-poisoned rats. Journal of Applied Biomedicine 7:4, pages 189-199.
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