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Research Article

Doxorubicin-induced female reproductive toxicity: an assessment of ovarian follicular apoptosis, cyclicity and reproductive tissue histology in Wistar rats

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Pages 72-81 | Received 27 Jan 2016, Accepted 08 Mar 2017, Published online: 25 Apr 2017

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Ashish Dogra, Dilpreet Kour, Abhishek Gour, Mahir Bhardwaj, Swarnendu Bag, Shakti Kumar Dhiman, Ajay Kumar, Gurdarshan Singh & Utpal Nandi. (2023) Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP. Drug and Chemical Toxicology 46:3, pages 597-608.
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Ahmed A. Morsi, Eman Mohamed Faruk, Engy Medhat, Neama M. Taha & Usama Fouad Ahmed Ebrahim. (2023) Modulatory effects of concomitant quercetin/sitagliptin administration on the ovarian histological and biochemical alterations provoked by doxorubicin in a streptozotocin-induced diabetic rat model. Journal of Histotechnology 46:2, pages 65-79.
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Kaviyarasi Renu, Lakshmi Prasanna Pureti, Balachandar Vellingiri & Abilash Valsala Gopalakrishnan. (2022) Toxic effects and molecular mechanism of doxorubicin on different organs – an update. Toxin Reviews 41:2, pages 650-674.
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Articles from other publishers (18)

Büşra CANDAN, Malik Ejder GÜLPAK & Perihan SEZGİNER. (2024) UTERUS DOKUSU ÜZERİNE DOKSORUBİSİN VE AGOMELATİN’İN ETKİLERİ: HİSTOPATOLOJİK BİR ÇALIŞMATHE EFFECTS OF DOXORUBICIN AND AGOMELATIN ON UTERUS TISSUE: A HISTOPATHOLOGICAL STUDY. SDÜ Tıp Fakültesi Dergisi.
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Ozge Cengiz Mat, Pinar Alisan Suna, Munevver Baran, Ayse Ceyhan & Arzu Yay. (2023) Studies on the ameliorative potential of dietary supplemented different dose of selenium on doxorubicin‐induced ovarian damage in rat. Journal of Biochemical and Molecular Toxicology 38:1.
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Amir Hosein Moslehi, Fatemeh Hoseinpour, Amir Saber, Maryam Akhavan Taheri & Amir Hossein Hashemian. (2023) Fertility-enhancing effects of inositol & vitamin C on cisplatin induced ovarian and uterine toxicity in rats via suppressing oxidative stress and apoptosis. Food and Chemical Toxicology 179, pages 113995.
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Jitender K. Bhardwaj, Prerna Bikal & Som Nath Sachdeva. (2023) Chemotherapeutic drugs induced female reproductive toxicity and treatment strategies. Journal of Biochemical and Molecular Toxicology 37:7.
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Shuhong Yang, Ting Ding, Wenqing Ma, Tong Wu, Milu Li, Wei Yan, Su Zhou, Ya Li, Li Tian, Wenwen Wang & Yong Tian. 2023. Ovarian Aging. Ovarian Aging 67 118 .
Christian Lee Andersen, Haeyeun Byun, Yuehuan Li, Shuo Xiao, Doris M Miller, Zidao Wang, Suvitha Viswanathan, Jonathan Matthew Hancock, Jaymie Bromfield & Xiaoqin Ye. (2021) Varied effects of doxorubicin (DOX) on the corpus luteum of C57BL/6 mice during early pregnancy†. Biology of Reproduction 105:6, pages 1521-1532.
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Zübeyir Huyut, Hamit Hakan Alp, Turan Yaman, Ömer Faruk Keleş, Zabit Yener, Fikret Türkan & Kemal Ayengin. (2020) Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity. Andrologia 53:2.
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Zi-Jie Fu, Xiao-Dong Li, Da-Wei Wei & Xue-Lei Ding. (2021) Clinical application potential of umbilical cord mesenchymal stem cells in chemotherapeutic ovarian failure. Reproductive and Developmental Medicine 5:1, pages 55.
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M Samare-Najaf, F Zal, S Safari, F Koohpeyma & N Jamali. (2020) Stereological and histopathological evaluation of doxorubicin-induced toxicity in female rats’ ovary and uterus and palliative effects of quercetin and vitamin E. Human & Experimental Toxicology 39:12, pages 1710-1724.
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Önder SAKİN, Muhammet Ali ORUÇ, Yasemin ALAN, Ali Doğukan ANĞIN & Kayhan BAŞAK. (2020) Investigation of protective effects of dehydroepiandrosterone (DHEA) against toxic damage caused by doxorubicin in rat ovariesInvestigation of Protective Effects of Dehydroepiandrosterone (DHEA) Against Toxic Damage Caused by Doxorubicin in Rat Ovaries. Konuralp Tıp Dergisi 12:3, pages 406-413.
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Mohammad Samare-Najaf, Fatemeh Zal & Solmaz Safari. (2020) Primary and Secondary Markers of Doxorubicin-Induced Female Infertility and the Alleviative Properties of Quercetin and Vitamin E in a Rat Model. Reproductive Toxicology 96, pages 316-326.
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Boodor Al-Kawlani, José Martin Murrieta-Coxca, Wittaya Chaiwangyen, Karolin Fröhlich, Andreas Fritzsche, Simone Winkler, Udo R. Markert & Diana M. Morales-Prieto. (2020) Doxorubicin induces cytotoxicity and miR-132 expression in granulosa cells. Reproductive Toxicology 96, pages 95-101.
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Jean Damascene Niringiyumukiza, Hongcai Cai, Li Chen, Yamin Li, Lingjuan Wang, Mengdi Zhang, Xiaoyan Xu & Wenpei Xiang. (2019) Protective properties of glycogen synthase kinase-3 inhibition against doxorubicin-induced oxidative damage to mouse ovarian reserve. Biomedicine & Pharmacotherapy 116, pages 108963.
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Huijuan Peng, Lihua Zeng, Ling Zhu, Songping Luo, Limian Xu, Lei Zeng, Jing Li, Qunying Liang & Hongling Geng. (2019) Zuogui Pills inhibit mitochondria-dependent apoptosis of follicles in a rat model of premature ovarian failure. Journal of Ethnopharmacology 238, pages 111855.
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Christian Lee Andersen, Mingjun Liu, Zidao Wang, Xiaoqin Ye & Shuo Xiao. (2019) Chemotherapeutic agent doxorubicin alters uterine gene expression in response to estrogen in ovariectomized CD-1 adult mice†. Biology of Reproduction 100:4, pages 869-871.
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Kaytee L. Pokrzywinski, Thomas G. Biel, Elliot T. Rosen, Julia L. Bonanno, Baikuntha Aryal, Francesca Mascia, Delaram Moshkelani, Steven Mog & V. Ashutosh Rao. (2018) Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats. Biology of Sex Differences 9:1.
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V. Y. Prokopiuk, A. M. GoltsevO. S. ProkopiukK. V. Somova & O. O. Loginova. (2018) EFFECT OF CRYOPRESERVED PLACENTAL EXPLANTS ON THE COURSE OF EXPERIMENTAL POLYCYSTIC OVARY SYNDROME. Bulletin of Problems Biology and Medicine 1.1:142, pages 167.
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V. Yu. Prokopiuk, O. O. LоginovaO. Prokopiuk & E. Somova. (2018) EFFECT OF CRYOPRESERVED PLACENTAL EXPLANTS ON THE OVARY RESTORATION AFTER TORSION TREATMENT. World of Medicine and Biology 14:63, pages 150.
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