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Drug and Chemical Toxicology Volume 42, 2019 - Issue 3
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Research Article

Cytotoxicity of acetylcholinesterase reactivators evaluated in vitro and its relation to their structure

Lubica MuckovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska, Hradec Kralove, Czech Republic; ORCID Iconhttp://orcid.org/0000-0001-6693-6061View further author information
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Jaroslav PejchalDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska, Hradec Kralove, Czech Republic; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-2228-7922View further author information
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Petr JostDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska, Hradec Kralove, Czech Republic; ORCID Iconhttp://orcid.org/0000-0002-1772-1651View further author information
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Nela VanovaDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska, Hradec Kralove, Czech Republic; ORCID Iconhttp://orcid.org/0000-0002-1827-9308View further author information
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David HermanDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska, Hradec Kralove, Czech Republic; ORCID Iconhttp://orcid.org/0000-0003-0784-4524View further author information
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Daniel JunDepartment of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska, Hradec Kralove, Czech Republic; ;Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska, Hradec Kralove, Czech RepublicORCID Iconhttp://orcid.org/0000-0002-0882-6304View further author information
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Pages 252-256 | Received 03 Nov 2017, Accepted 20 Jan 2018, Published online: 09 Feb 2018

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Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles & Kamil Kuca. (2022) Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities. Journal of Enzyme Inhibition and Medicinal Chemistry 37:1, pages 2605-2620.
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Lukas Gorecki, Lucie Junova, Tomas Kucera, Vendula Hepnarova, Lukas Prchal, Tereza Kobrlova, Lubica Muckova, Ondrej Soukup & Jan Korabecny. (2019) Tacroximes: Novel Unique Compounds for the Recovery of Organophosphorus-Inhibited Acetylcholinesterase. Future Medicinal Chemistry 11:20, pages 2625-2634.
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Articles from other publishers (19)

Nela Váňová, L’ubica Múčková, Tereza Kalíšková, Lukáš Lochman, Petr Bzonek & František Švec. (2023) In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. Chemical Research in Toxicology 36:12, pages 1912-1920.
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Teodorico C. Ramalho, Alexandre A. de Castro, Daniel H.S. Leal, Jessika P. Teixeira, Elaine F.F. da Cunha & Kamil Kuca. (2023) Assessing the Therapeutic and Toxicological Profile of Novel Acetylcholinesterase Reactivators: Value of In Silico And In Vitro Data . Current Medicinal Chemistry 30:36, pages 4149-4166.
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Gabriele Horn, Tamara Kranawetvogl, Harald John, Carlotta Weigel, Ursula Rauen, Franz Worek & Timo Wille. (2023) Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro. Chemico-Biological Interactions 369, pages 110285.
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Jana Zdarova Karasova, Jiri Kassa, Vendula Hepnarova, Jaroslav Pejchal, Lucie Junova, Rudolf Andrys, David Malinak, Petr Bzonek, Zuzana Kohoutova & Kamil Musilek. (2022) Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870. Food and Chemical Toxicology 167, pages 113236.
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Antonio Zandona, Nikola Maraković, Petra Mišetić, Josip Madunić, Katarina Miš, Jasna Padovan, Sergej Pirkmajer & Maja Katalinić. (2021) Activation of (un)regulated cell death as a new perspective for bispyridinium and imidazolium oximes. Archives of Toxicology 95:8, pages 2737-2754.
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Eugenie Nepovimova, Lucie Svobodova, Rafael Dolezal, Vendula Hepnarova, Lucie Junova, Daniel Jun, Jan Korabecny, Tomas Kucera, Zuzana Gazova, Katarina Motykova, Jana Kubackova, Zuzana Bednarikova, Jana Janockova, Catarina Jesus, Luisa Cortes, Joao Pina, Danijela Rostohar, Carlos Serpa, Ondrej Soukup, Laura Aitken, Rebecca E. Hughes, Kamil Musilek, Lubica Muckova, Petr Jost, Marketa Chvojkova, Karel Vales, Martin Valis, Zofia Chrienova, Katarina Chalupova & Kamil Kuca. (2021) Tacrine – Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems. Bioorganic Chemistry 107, pages 104596.
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Ozgur Esim, Ayhan Savaser, Cansel K. Ozkan, Ali Oztuna, Berk Alp Goksel, Mehmet Ozler, Cetin Tas & Yalcin Ozkan. (2020) Nose to brain delivery of eletriptan hydrobromide nanoparticles: Preparation, in vitro/in vivo evaluation and effect on trigeminal activation. Journal of Drug Delivery Science and Technology 59, pages 101919.
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Sermet Sezigen, Ozgur Esim, Meral Sarper & Ayhan Savaser. (2020) In vitro evaluation of two different types of obidoxime-loaded nanoparticles for cytotoxicity and blood-brain barrier transport. Toxicology Letters 330, pages 53-58.
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André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati & Florian Nachon. (2020) Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime. Biomolecules 10:6, pages 858.
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Ozgur Esim, Meral Sarper, Cansel K. Ozkan, Sema Oren, Baris Baykal, Ayhan Savaser & Yalcin Ozkan. (2020) Effect simultaneous delivery with P-glycoprotein inhibitor and nanoparticle administration of doxorubicin on cellular uptake and in vitro anticancer activity. Saudi Pharmaceutical Journal 28:4, pages 465-472.
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Jana Zdarova Karasova, Vendula Hepnarova, Rudolf Andrys, Miroslav Lisa, Petr Jost, Lubica Muckova, Jaroslav Pejchal, David Herman, Daniel Jun, Jiri Kassa & Kamil Kuca. (2020) Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness. Toxicology Letters 320, pages 64-72.
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Alzbeta Filipova, Jan Marek, Radim Havelek, Jaroslav Pejchal, Marcela Jelicova, Jana Cizkova, Martina Majorosova, Lubica Muckova, Tomas Kucera, Lukas Prchal, Miroslav Psotka, Natalie Zivna, Darja Koutova, Zuzana Sinkorova, Martina Rezacova & Ales Tichy. (2020) Substituted Piperazines as Novel Potential Radioprotective Agents. Molecules 25:3, pages 532.
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Vendula Hepnarova, Lubica Muckova, Avi Ring, Jaroslav Pejchal, David Herman, Jan Misik, Martina Hrabinova, Daniel Jun & Ondrej Soukup. (2019) Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators. Toxicology and Applied Pharmacology 383, pages 114776.
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Barbora Svobodova, Eva Mezeiova, Vendula Hepnarova, Martina Hrabinova, Lubica Muckova, Tereza Kobrlova, Daniel Jun, Ondrej Soukup, María Luisa Jimeno, José Marco-Contelles & Jan Korabecny. (2019) Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors. Biomolecules 9:8, pages 379.
Crossref
Dietrich E. Lorke & Georg A. Petroianu. (2019) The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime. Frontiers in Neuroscience 13.
Crossref
Dietrich E. Lorke & Georg A. Petroianu. (2018) Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates. A review. Journal of Applied Toxicology 39:1, pages 101-116.
Crossref
Tamara Zorbaz, David Malinak, Nikola Maraković, Nikolina Maček Hrvat, Antonio Zandona, Michal Novotny, Adam Skarka, Rudolf Andrys, Marketa Benkova, Ondrej Soukup, Maja Katalinić, Kamil Kuca, Zrinka Kovarik & Kamil Musilek. (2018) Pyridinium Oximes with Ortho -Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents . Journal of Medicinal Chemistry 61:23, pages 10753-10766.
Crossref
Nela Vanova, Lubica Muckova, Monika Schmidt, David Herman, Alzbeta Dlabkova, Jaroslav Pejchal & Daniel Jun. (2018) Simultaneous determination of malondialdehyde and 3‐nitrotyrosine in cultured human hepatoma cells by liquid chromatography–mass spectrometry. Biomedical Chromatography 32:12.
Crossref
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Nemcikova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles & Kamil Kuca. (2022) Privileged Multi-Target Directed Propargyl-Tacrines Combining Cholinesterase and Monoamine Oxidase Inhibition Activities. SSRN Electronic Journal.
Crossref

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