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Drug and Chemical Toxicology Volume 43, 2020 - Issue 5
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Research Articles

Gastroprotective effects of oleuropein and thymol on indomethacin-induced gastric ulcer in Sprague-Dawley rats

Kubra KocDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-6208-165XView further author information
ORCID Icon,
Salim CerigDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; View further author information
,
Serap UcarDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; View further author information
,
Suat ColakDepartment of Biology, Erzincan University, Erzincan, Turkey; View further author information
,
Murat BakirDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; View further author information
,
Huseyin Serkan ErolDepartment of Biochemistry, Faculty of Veterinary, Ataturk University, Erzurum, Turkey; View further author information
,
Serkan YildirimDepartment of Pathology, Faculty of Veterinary, Ataturk University, Erzurum, Turkey; View further author information
,
Mirkhalil HosseinigouzdaganiDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; View further author information
,
Nihal Simsek OzekDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; View further author information
,
Ferhunde AysinDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; ;East Anatolian High Technology Research and Application Center (DAYTAM), Ataturk University, Erzurum, Turkey; View further author information
,
Enver Fehim KocpinarDepartment of Medical Laboratory, Techniques Vocational School of Health Services, Alparslan University, Mus, Turkey; View further author information
,
Harun BudakDepartment of Molecular Biology and Genetics, Faculty of Science, Ataturk University, Erzurum, TurkeyView further author information
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Fatime GeyikogluDepartment of Biology, Faculty of Science, Ataturk University, Erzurum, Turkey; View further author information
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Pages 441-453 | Received 07 Apr 2018, Accepted 23 Sep 2018, Published online: 14 Nov 2018

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Samia Oueslati, Raja Serairi Beji, Feten Zar Kalai, Merieme Soufiani, Walid Zorrig, Salama Aissam, Kamel Msaada & Cherkaoui El Modafar. (2024) Antioxidant potentialities and gastroprotective effect of Reichardia picroides extracts on Ethanol/HCl induced gastric ulcer rats. International Journal of Environmental Health Research 34:2, pages 1088-1099.
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Ashish Dogra, Dilpreet Kour, Abhishek Gour, Mahir Bhardwaj, Swarnendu Bag, Shakti Kumar Dhiman, Ajay Kumar, Gurdarshan Singh & Utpal Nandi. (2023) Ameliorating effect of rutin against diclofenac-induced cardiac injury in rats with underlying function of FABP3, MYL3, and ANP. Drug and Chemical Toxicology 46:3, pages 597-608.
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Gulsah Yildiz Deniz. (2019) The Protective Effects of Thymol Against Ketoprofen Induced Damages on Pancreatic Acinar and Islet of Langerhans Cells in Rats. Journal of Essential Oil Bearing Plants 22:3, pages 604-613.
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Articles from other publishers (20)

A.M. Abu Ahmed, Farjana Sharmen, Md. Atiar Rahman, Md. Amjad Hossen, Md. Shahidul Islam, Md. Mamunur Rashid, Md. Khalid Juhani Rafi, Tanvir Ahmed Siddiqui, A.S.M. Ali Reza, Srabonti Saha & Manal M.S. Mansoury. (2024) Epiphytic orchids alleviate ethanol-induced gastric ulcers in the Long-Evan rats via regulating antioxidant enzyme levels. South African Journal of Botany 168, pages 610-621.
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Hend Abd-Allah, John Youshia, Gehad A. Abdel Jaleel, Azza Hassan, Mevidette El Madani & Maha Nasr. (2024) Gastroprotective Chitosan Nanoparticles Loaded with Oleuropein: An In Vivo Proof of Concept. Pharmaceutics 16:1, pages 153.
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Yasmen F. Mahran, Layla A. Al-Kharashi, Reem T. Atawia, Rawan Turki Alanazi, Amal M. Bin Dhahi, Rawd Alsubaie & Amira M. Badr. (2023) Radioprotective Effects of Carvacrol and/or Thymol against Gamma Irradiation-Induced Acute Nephropathy: In Silico and In Vivo Evidence of the Involvement of Insulin-like Growth Factor-1 (IGF-1) and Calcitonin Gene-Related Peptide. Biomedicines 11:9, pages 2521.
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Rasha M. Hussein, El-Shaimaa A. Arafa, Sayed Abdel Raheem & Wafaa R. Mohamed. (2023) Thymol protects against bleomycin-induced pulmonary fibrosis via abrogation of oxidative stress, inflammation, and modulation of miR-29a/TGF-β and PI3K/Akt signaling in mice. Life Sciences 314, pages 121256.
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Thadiyan Parambil Ijinu, Bernard Prabha, Palpu Pushpangadan & Varughese George. 2023. Drug Discovery and Design Using Natural Products. Drug Discovery and Design Using Natural Products 103 149 .
Reza Rostami, Zahra Eslamifar, Sedighe Nazemi, Seyedeh Zeinab Hosseini, Mohammad mehdi Behvandi & Leila Jafaripour. (2022) The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats. BioMed Research International 2022, pages 1-8.
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Yao Liu, Hui Yan, Bing Yu, Jun He, Xiangbing Mao, Jie Yu, Ping Zheng, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Aimin Wu & Daiwen Chen. (2022) Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties. Antioxidants 11:10, pages 1947.
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Feixue Liu, Yan Wang, Babatunde Kazeem Bello, Hui Fan, Gang Liu, Xiao Zhang, Tianmeng Zhang, Zibo Dong, Xin Feng, Yi Chen, Daoyang Teng & Jingquan Dong. (2022) Protective effects of scutellarin on acute alcohol gastric injury. Biologia 77:9, pages 2609-2617.
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Sawsan M.A. El-Sheikh, Hadeer M. Bahaa, Azza A.A. Galal, Mohamed M.M. Metwally, Mahmoud A. Said, Reham H. Alattar & Esraa M. Fahmy. (2022) Gastroprotective, hepatoprotective, and nephroprotective effects of thymol against the adverse effects of acetylsalicylic acid in rats: Biochemical and histopathological studies. Saudi Journal of Biological Sciences 29:6, pages 103289.
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Joana Madureira, Fernanda M. A. Margaça, Celestino Santos‐Buelga, Isabel C. F. R. Ferreira, Sandra Cabo Verde & Lillian Barros. (2021) Applications of bioactive compounds extracted from olive industry wastes: A review. Comprehensive Reviews in Food Science and Food Safety 21:1, pages 453-476.
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Layla A. Al‐Khrashi, Amira M. Badr, Maha A. AL‐Amin & Yasmen F. Mahran. (2021) Thymol ameliorates 5‐fluorouracil‐induced intestinal mucositis: Evidence of down‐regulatory effect on TGF‐β/MAPK pathways through NF‐κB. Journal of Biochemical and Molecular Toxicology 36:1.
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Yizi Zhang, Lingli Sun, Xingfei Lai, Xingjia Peng, Shuai Wen, Zhenbiao Zhang, Yinzheng Xie, Qiuhua Li, Ruohong Chen, Xi Zheng, Kun Zhang, Shili Sun & Dongli Li. (2021) Gastroprotective effects of extract of Jasminum grandiflorum L. flower in HCl/EtOH-induced gastric mucosal ulceration mice. Biomedicine & Pharmacotherapy 144, pages 112268.
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Catarina Alves de Lima Serafim, Maria Elaine Cristina Araruna, Edvaldo Balbino Alves Júnior, Leiliane Macena Oliveira Silva, Alessa Oliveira Silva, Marcelo Sobral da Silva, Adriano Francisco Alves, Aurigena Antunes Araújo & Leônia Maria Batista. (2021) (-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models. Frontiers in Pharmacology 12.
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Ratnabali Maity, Prabir Mondal, Mukul Kumar Giri, Chaitali Ghosh & Chhanda Mallick. (2021) Gastroprotective effect of hydromethanolic extract of Ayapana triplinervis leaves on indomethacin‐induced gastric ulcer in male Wistar rats . Journal of Food Biochemistry 45:8.
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Hengfang Zhao, Xiaoyan Zhang, Bojing Zhang & Xiaoyuan Qu. (2021) Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities. Open Life Sciences 16:1, pages 719-727.
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Zully J. Suárez Montenegro, Gerardo Álvarez-Rivera, José David Sánchez-Martínez, Rocío Gallego, Alberto Valdés, Mónica Bueno, Alejandro Cifuentes & Elena Ibáñez. (2021) Neuroprotective Effect of Terpenoids Recovered from Olive Oil By-Products. Foods 10:7, pages 1507.
Crossref
Zully J. Suárez Montenegro, Gerardo Álvarez-Rivera, Jose A. Mendiola, Elena Ibáñez & Alejandro Cifuentes. (2021) Extraction and Mass Spectrometric Characterization of Terpenes Recovered from Olive Leaves Using a New Adsorbent-Assisted Supercritical CO2 Process. Foods 10:6, pages 1301.
Crossref
Houpan Song, Meiyan Zeng, Xiaojuan Chen, Xinyi Chen, Jun Peng, Ye Lin, Rong Yu, Xiong Cai & Qinghua Peng. (2020) Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-14.
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Yasmen F. Mahran, Amira M. Badr, Alhanouf Aldosari, Raghad Bin-Zaid & Hind N. Alotaibi. (2019) Carvacrol and Thymol Modulate the Cross-Talk between TNF-α and IGF-1 Signaling in Radiotherapy-Induced Ovarian Failure. Oxidative Medicine and Cellular Longevity 2019, pages 1-10.
Crossref
Tiziana Larussa, Maria Imeneo & Francesco Luzza. (2019) Olive Tree Biophenols in Inflammatory Bowel Disease: When Bitter is Better. International Journal of Molecular Sciences 20:6, pages 1390.
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