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Drug and Chemical Toxicology Volume 44, 2021 - Issue 2
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Research Articles

Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin

Ramona FigatDepartment of Environmental Health Sciences, Medical University of Warsaw, Poland; Correspondence[email protected]
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Anna ZgadzajDepartment of Environmental Health Sciences, Medical University of Warsaw, Poland; View further author information
,
Sylwia GeschkeDepartment of Environmental Health Sciences, Medical University of Warsaw, Poland; View further author information
,
Patrycja SieczkaDepartment of Environmental Health Sciences, Medical University of Warsaw, Poland; View further author information
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Agnieszka PietrosiukDepartment of Pharmaceutical Biology and Medicinal Plant Biotechnology, Medical University of Warsaw, Poland; View further author information
,
Sylwester SommerCentre for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Warsaw, PolandView further author information
&
Agata SkrzypczakDepartment of Environmental Health Sciences, Medical University of Warsaw, Poland; View further author information
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Pages 140-147 | Received 12 Jun 2018, Accepted 11 Oct 2018, Published online: 21 Dec 2018

Citations (12)

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Zhiqin Zhang, Jie Bai, Yawen Zeng, Mengru Cai, Yu Yao, Huimin Wu, Longtai You, Xiaoxv Dong & Jian Ni. (2020) Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review. Pharmaceutical Biology 58:1, pages 950-958.
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Articles from other publishers (11)

Vaishali Yadav, Jorge L. Fuentes, Anuja Krishnan, Neenu Singh & Divya Vohora. (2024) Guidance for the use and interpretation of assays for monitoring anti-genotoxicity. Life Sciences 337, pages 122341.
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Yuming Huang, Linchuan Lei, Zhuoyang Zhao, Zemin Li, Hua Wang, Shunlun Chen, Jinjian Zheng, Guowei Jiang, Xingyu Guo, Jiamin Li, Jianru Wang, Zhaomin Zheng & Fan Chen. (2023) Acetylshikonin promoting PI3K/Akt pathway and inhibiting SOX4 expression to delay intervertebral disc degeneration and low back pain. Journal of Orthopaedic Research 42:1, pages 172-182.
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Shih-Sen Lin, Tsung-Ming Chang, Augusta I-Chin Wei, Chiang-Wen Lee, Zih-Chan Lin, Yao-Chang Chiang, Miao-Ching Chi & Ju-Fang Liu. (2023) Acetylshikonin induces necroptosis via the RIPK1/RIPK3-dependent pathway in lung cancer. Aging 15:24, pages 14900-14914.
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Wenjing Guo, Xin Wang, Chao Sun, Jian Wang & Tao Wang. (2023) Shikonin ameliorates salivary gland damage and inflammation in a mouse model of Sjögren’s syndrome by modulating MAPK signaling pathway. The Korean Journal of Physiology & Pharmacology 27:4, pages 357-364.
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Hua Zhong, Lei Han, Ren-Yi Lu & Yan Wang. (2022) Antifungal and Immunomodulatory Ingredients from Traditional Chinese Medicine. Antibiotics 12:1, pages 48.
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Xuan Wang, Zhuoyu He, Huan Yang, Cong He, Changyi Wang, Aliya Fazal, Xiaohui Lai, Liangjie Yang, Zhongling Wen, Minkai Yang, Shenglin Ma, Wencai Jie, Jinfeng Cai, Tongming Yin, Bao Liu, Yonghua Yang & Jinliang Qi. (2022) Genome-Wide Identification of LeBAHDs in Lithospermum erythrorhizon and In Vivo Transgenic Studies Confirm the Critical Roles of LeBAHD1/LeSAT1 in the Conversion of Shikonin to Acetylshikonin. Life 12:11, pages 1775.
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Ricardo J.B. Leote, Caroline G. Sanz & Victor C. Diculescu. (2022) Electrochemical characterization of shikonin and in-situ evaluation of interaction with DNA. Journal of Electroanalytical Chemistry 921, pages 116663.
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Snehlata Yadav, Ajay Sharma, Gulzar Ahmad Nayik, Raymond Cooper, Garima Bhardwaj, Harvinder Singh Sohal, Vishal Mutreja, Ramandeep Kaur, Franklin Ore Areche, Mohannad AlOudat, Ayaz Mukarram Shaikh, Béla Kovács & Abdelhakam Esmaeil Mohamed Ahmed. (2022) Review of Shikonin and Derivatives: Isolation, Chemistry, Biosynthesis, Pharmacology and Toxicology. Frontiers in Pharmacology 13.
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Heui Min Lim, Jongsung Lee, Seon Hak Yu, Myeong Jin Nam, Hyo Sun Cha, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang & See-Hyoung Park. (2022) Acetylshikonin, A Novel CYP2J2 Inhibitor, Induces Apoptosis in RCC Cells via FOXO3 Activation and ROS Elevation. Oxidative Medicine and Cellular Longevity 2022, pages 1-20.
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Ming Hong, Jinke Li, Siying Li & Mohammed M.Almutairi. (2019) Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation. Cells 8:11, pages 1466.
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Nidhi Sharma, Ashu Gulati, Dharmesh Kumar & Yogendra Padwad. (2019) Naphthazarins as cytotoxic agents isolated from Arnebia euchroma. Pharmacognosy Magazine 15:64, pages 366.
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