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Drug and Chemical Toxicology Volume 44, 2021 - Issue 2
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Research Articles

Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study

Vahideh GhoraniPharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; ;Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information
,
Azam AlavinezhadDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; ;Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information
,
Omid RajabiDepartment of Drug and Food Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; View further author information
,
Amir Hooshang MohammadpourPharmaceutical Research Center, Pharmaceutical Institute of Technology, Mashhad University of Medical Sciences, Mashhad, Iran; ;Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranView further author information
&
Mohammad Hossein BoskabadyDepartment of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; ;Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Correspondence[email protected] [email protected]
View further author information
Pages 177-189 | Received 10 Jun 2018, Accepted 15 Oct 2018, Published online: 29 Nov 2018

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Gleyce HA de Souza, Marcia SM Vaz, Joyce A dos Santos Radai, Thiago L Fraga, Luana Rossato & Simone Simionatto. (2024) Synergistic Interaction of Polymyxin B with Carvacrol: Antimicrobial Strategy Against Polymyxin-Resistant Klebsiella Pneumoniae. Future Microbiology 19:3, pages 181-193.
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Articles from other publishers (21)

Mansi, Vikas Garg & Bidya Dhar Sahu. (2024) Carvacrol and its effect on cardiovascular diseases: From molecular mechanism to pharmacological modulation. Food Bioscience 57, pages 103444.
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Arghavan Memarzia, Saeideh Saadat, Fereshteh Asgharzadeh, Sepide Behrouz, Gert Folkerts & Mohammad Hossein Boskabady. (2023) Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence. Journal of Cellular and Molecular Medicine 27:19, pages 2841-2863.
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Rebecca Büttner, Melanie Schwermer, Thomas Ostermann, Alfred Längler & Tycho Zuzak. (2023) Complementary and alternative medicine in the (symptomatic) treatment of acute tonsillitis in children: A systematic review. Complementary Therapies in Medicine 73, pages 102940.
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Wanda Mączka, Martyna Twardawska, Małgorzata Grabarczyk & Katarzyna Wińska. (2023) Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties. Antibiotics 12:5, pages 824.
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Serkan Cerrah, Fatih Ozcicek, Betul Gundogdu, Betul Cicek, Taha Abdulkadir Coban, Bahadir Suleyman, Durdu Altuner, Seval Bulut & Halis Suleyman. (2023) Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats. Frontiers in Pharmacology 14.
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Lucia Caputo, Giuseppe Amato, Laura De Martino, Vincenzo De Feo & Filomena Nazzaro. (2023) Anti-Cholinesterase and Anti-α-Amylase Activities and Neuroprotective Effects of Carvacrol and p-Cymene and Their Effects on Hydrogen Peroxide Induced Stress in SH-SY5Y Cells. International Journal of Molecular Sciences 24:7, pages 6073.
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Amr Gamal, Shawky M. Aboelhadid, Fatma I. Abo El-Ela, Abdel-Azeem S. Abdel-Baki, Samar M. Ibrahium, Almahy M. EL-Mallah, Saleh Al-Quraishy, Ahmed O. Hassan & Sahar M. Gadelhaq. (2023) Synthesis of Carvacrol-Loaded Invasomes Nanoparticles Improved Acaricide Efficacy, Cuticle Invasion and Inhibition of Acetylcholinestrase against Hard Ticks. Microorganisms 11:3, pages 733.
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Antonio López-Gómez, Alejandra Navarro-Martínez & Ginés Benito Martínez-Hernández. (2023) Effects of essential oils released from active packaging on the antioxidant system and quality of lemons during cold storage and commercialization. Scientia Horticulturae 312, pages 111855.
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Irene Fernández-Babiano, María Luisa Navarro-Pérez, Ciro Pérez-Giraldo & María Coronada Fernández-Calderón. (2022) Antibacterial and Antibiofilm Activity of Carvacrol against Oral Pathogenic Bacteria. Metabolites 12:12, pages 1255.
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Pablo Gutiérrez-Sánchez, Pablo Navarro, Silvia Álvarez-Torrellas, Juan García & Marcos Larriba. (2022) Extraction of neonicotinoid pesticides from aquatic environmental matrices with sustainable terpenoids and eutectic solvents. Separation and Purification Technology 302, pages 122148.
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Muhammad Imran, Mahwish Aslam, Suliman A. Alsagaby, Farhan Saeed, Ishtiaque Ahmad, Muhamamd Afzaal, Muhammad Umair Arshad, Mohamed A. Abdelgawad, Ahmed H. El‐Ghorab, Ahmed Khames, Mohammad Ali Shariati, Arslan Ahmad, Muzamal Hussain, Ali Imran & Saiful Islam. (2022) Therapeutic application of carvacrol: A comprehensive review. Food Science & Nutrition 10:11, pages 3544-3561.
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Mahammad R. Khazdair, Vahideh Ghorani & Mohammad H. Boskabady. (2022) Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review. BioFactors 48:4, pages 779-794.
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Basak Atas, Cemile Selin Aksoy, Fatma Gizem Avci, Nihat Alpagu Sayar, Kutlu Ulgen, Elif Ozkirimli & Berna Sariyar Akbulut. (2022) Carvacrol Enhances the Antimicrobial Potency of Berberine in Bacillus subtilis. Current Microbiology 79:5.
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Rana A. Elmesseri, Sarra E. Saleh, Heba M. Elsherif, Ibrahim S. Yahia & Khaled M. Aboshanab. (2022) Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents. Antibiotics 11:3, pages 298.
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María I Duran, Ricardo Ballesteros-Ramírez, Angélica Tellez, Lilian Torregrosa, Peter A Olejua, Silvia Galvis, Claudia Urueña & Susana Fiorentino. (2022) Safety Evaluation in Healthy Colombian Volunteers of P2Et Extract Obtained from Caesalpinia spinosa: Design 3+3 Phase I Clinical Trial. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-11.
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Fernanda Oliveira de Carvalho, Jessica Paloma Rosa Silva, Érika Ramos Silva, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Paula Santos Nunes & Adriano Antunes de Souza Araújo. (2021) Would carvacrol be a supporting treatment option effective in minimizing the deleterious effects of COVID-19?. Naunyn-Schmiedeberg's Archives of Pharmacology 394:12, pages 2471-2474.
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Nikheel Bhojraj Rathod, Piotr Kulawik, Fatih Ozogul, Joe M. Regenstein & Yesim Ozogul. (2021) Biological activity of plant-based carvacrol and thymol and their impact on human health and food quality. Trends in Food Science & Technology 116, pages 733-748.
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Laeza Alves Sampaio, Lícia Tairiny Santos Pina, Mairim Russo Serafini, Débora dos Santos Tavares & Adriana Gibara Guimarães. (2021) Antitumor Effects of Carvacrol and Thymol: A Systematic Review. Frontiers in Pharmacology 12.
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Li Wang, Dan Wang, Xingan Wu, Rui Xu & Yunlan Li. (2020) Antiviral mechanism of carvacrol on HSV-2 infectivity through inhibition of RIP3-mediated programmed cell necrosis pathway and ubiquitin-proteasome system in BSC-1 cells. BMC Infectious Diseases 20:1.
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Konstantina Kalyvianaki, Panagiotis Malamos, Niki Mastrodimou, Ioanna Manoura-Zonou, Rodanthi Vamvoukaki, George Notas, Niki Malliaraki, Eleni Moustou, Maria Tzardi, Stergios Pirintsos, Christos Lionis, George Sourvinos, Elias Castanas & Marilena Kampa. (2020) Toxicity evaluation of an essential oil mixture from the Cretan herbs thyme, Greek sage and Cretan dittany. npj Science of Food 4:1.
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Vahideh Ghorani, Omid Rajabi, Majid Mirsadraee, Fariba Rezaeitalab, Saeideh Saadat & Mohammad Hossein Boskabady. (2020) A Randomized, Doubled‐Blind Clinical Trial on the Effect of Zataria multiflora on Clinical Symptoms, Oxidative Stress, and C‐Reactive Protein in COPD Patients . The Journal of Clinical Pharmacology 60:7, pages 867-878.
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