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Drug and Chemical Toxicology Volume 44, 2021 - Issue 3
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Research Articles

Cardiotoxicity evaluation and comparison of diterpene alkaloids on zebrafish

Qiang Yea The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Hongmei Liua The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Chengxin Fanga The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Yushi Liua The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Xiaomei Liua The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Juanru Liua The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Cunyan Zhanga The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Tingmo Zhanga The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaView further author information
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Cheng Penga The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCorrespondence[email protected] [email protected]
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Li Guoa The Ministry of Education, Key Laboratory of standardization of Chinese herbal medicine, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China;b The Breeding Base of State Key Laboratory of resources systems research and development, Utilization of Chinese Herbal Medicines Constructed by The Ministry of Science and Technology of the PRC, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaCorrespondence[email protected] [email protected]
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Pages 294-301 | Received 22 Oct 2018, Accepted 16 Feb 2019, Published online: 21 Mar 2019

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Nannan Yang, Jiafu Guo, Jian Zhang, Song Gao, Qiwen Xiang, Jiayu Wen, Yan Huang, Chaolong Rao & Yan Chen. A toxicological review of alkaloids. Drug and Chemical Toxicology 0:0, pages 1-15.
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Catalina Mares, Ana-Maria Udrea, Catalin Buiu, Angela Staicu & Speranta Avram. (2024) Therapeutic Potentials of Aconite-like Alkaloids: Bioinformatics and Experimental Approaches. Mini-Reviews in Medicinal Chemistry 24:2, pages 159-175.
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Yinlin Zhou, Can Qu, Hongling Yan, Tianzhe Chu, Jing Wu, Qinzhao Kang, Cheng Peng, Yulan Wang & Yuzhu Tan. (2024) Unlocking the hidden potential: Enhancing the utilization of stems and leaves through metabolite analysis and toxicity assessment of various parts of Aconitum carmichaelii. Journal of Ethnopharmacology 323, pages 117693.
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Liangliang Song, Shuo Mi, Ying Zhao, Ziqin Liu, Jing Wang, Hongyue Wang, Wenhui Li, Jiasheng Wang, Wenting Zu & Hong Du. (2024) Integrated virtual screening and in vitro studies for exploring the mechanism of triterpenoids in Chebulae Fructus alleviating mesaconitine-induced cardiotoxicity via TRPV1 channel. Frontiers in Pharmacology 15.
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Gelin Xiang, Sa Guo, Jing Qin, Huimin Gao, Yi Zhang & Shaohui Wang. (2024) Comprehensive insight into the pharmacology, pharmacokinetics, toxicity, detoxification and extraction of hypaconitine from Aconitum plants. Journal of Ethnopharmacology 321, pages 117505.
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Qian Chen, Xinqi Deng, Kai Zhang, Yingquan Kang, Mingjie Jiao, Jia Zhang, Chunguo Wang & Fei Li. (2023) Changes to PUFA-PPAR pathway during mesaconitine induced myocardial coagulative necrosis. Food and Chemical Toxicology 177, pages 113831.
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Jingyang Sun & Juanjuan Guo. (2023) Acute Traditional Chinese Medicine Fuzi Poisoning: A Case Report. International Journal of Biology and Life Sciences 3:1, pages 50-52.
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Guannan He, Xiaoxin Wang, Weiran Liu, Yuling Li, Yumeng Shao, Weidong Liu, Xiaodong Liang & Xia Bao. (2023) Chemical constituents, pharmacological effects, toxicology, processing and compatibility of Fuzi (lateral root of Aconitum carmichaelii Debx): A review. Journal of Ethnopharmacology 307, pages 116160.
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Xue Yang, Chang Wang, Qi Zheng, Qiongyu Liu, Nicholas J. P. Wawryk & Xing-Fang Li. (2022) Emerging Disinfection Byproduct 2,6-Dichlorobenzoquinone-Induced Cardiovascular Developmental Toxicity of Embryonic Zebrafish and Larvae: Imaging and Transcriptome Analysis. ACS Omega 7:49, pages 45642-45653.
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Zehua Liang, Yuquan He & Xin Hu. (2022) Cardio-Oncology: Mechanisms, Drug Combinations, and Reverse Cardio-Oncology. International Journal of Molecular Sciences 23:18, pages 10617.
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Liuying Li, Limin Zhang, Tingting Liao, Chuantao Zhang, Keling Chen & Qun Huang. (2022) Advances on pharmacology and toxicology of aconitine. Fundamental & Clinical Pharmacology 36:4, pages 601-611.
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Jia-Wen Song, Yu-Shi Liu, Yu-Rou Guo, Wen-Xiao Zhong, Yi-Ping Guo & Li Guo. (2022) Nano–Liposomes Double Loaded with Curcumin and Tetrandrine: Preparation, Characterization, Hepatotoxicity and Anti–Tumor Effects. International Journal of Molecular Sciences 23:12, pages 6858.
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Hong Jiang, Yating Zhang, Yi Zhang, Xiaobo Wang & Xianli Meng. (2022) An Updated Meta-Analysis Based on the Preclinical Evidence of Mechanism of Aconitine-Induced Cardiotoxicity. Frontiers in Pharmacology 13.
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Shu Han, Liyuan Bao, Weifei Li, Kaiyang Liu, Ya’nan Tang, Xitao Han, Ziqin Liu, Hongyue Wang, Fengting Zhang, Shuo Mi & Hong Du. (2022) Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-12.
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Yan-Yu Zhang, Yun-Da Yao, Qi-Qing Cheng, Yu-Feng Huang & Hua Zhou. (2022) Establishment of a High Content Image Platform to Measure NF-κB Nuclear Translocation in LPS-induced RAW264.7 Macrophages for Screening Anti-inflammatory Drug Candidates. Current Drug Metabolism 23:5, pages 394-414.
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Jie Zhou, Cheng Peng, Qiuju Li, Xiaoyu Yan, Liang Yang, Mengting Li, Xiaoyu Cao, Xiaofang Xie, Dayi Chen, Chaolong Rao, Sizhou Huang, Fu Peng & Xiaoqi Pan. (2022) Dopamine Homeostasis Imbalance and Dopamine Receptors-Mediated AC/cAMP/PKA Pathway Activation are Involved in Aconitine-Induced Neurological Impairment in Zebrafish and SH-SY5Y Cells. Frontiers in Pharmacology 13.
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Amin Mahmood Thawabteh, Alà Thawabteh, Filomena Lelario, Sabino Aurelio Bufo & Laura Scrano. (2021) Classification, Toxicity and Bioactivity of Natural Diterpenoid Alkaloids. Molecules 26:13, pages 4103.
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Wei Zhou, Hong Liu, Li‐Zhen Qiu, Lan‐Xin Yue, Guang‐Jie Zhang, Hui‐Fang Deng, Yu‐Hao Ni & Yue Gao. (2021) Cardiac efficacy and toxicity of aconitine: A new frontier for the ancient poison. Medicinal Research Reviews 41:3, pages 1798-1811.
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Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li & Kechun Liu. (2021) Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos. Frontiers in Pharmacology 12.
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Amir Modarresi Chahardehi, Hasni Arsad & Vuanghao Lim. (2020) Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants. Plants 9:10, pages 1345.
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Kang Luo, Haicheng Chen, Qing Zhou, Zhihong Yan, Zhengquan Su & Kang Li. (2020) A facile one step solvothermal controllable synthesis of FeS2 quantum dots with multiple color emission for the visual detection of aconitine. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 240, pages 118563.
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Wei Zhou, Li-zhen Qiu, Hong Liu, Hui-Fang Deng, Lan-Xin Yue & Yue Gao. (2020) Notch1-mediated histone demethylation of HCN4 contributes to aconitine-induced ventricular myocardial dysrhythmia. Toxicology Letters 327, pages 19-31.
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Yong Shen, Wen-Juan Liang, Ya-Na Shi, Edward J. Kennelly & Da-Ke Zhao. (2020) Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids. Natural Product Reports 37:6, pages 763-796.
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Steven Cassar, Isaac Adatto, Jennifer L. Freeman, Joshua T. Gamse, Iñaki Iturria, Christian Lawrence, Arantza Muriana, Randall T. Peterson, Steven Van Cruchten & Leonard I. Zon. (2019) Use of Zebrafish in Drug Discovery Toxicology. Chemical Research in Toxicology 33:1, pages 95-118.
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Chanika D. Jayasinghe & Uthpala A. Jayawardena. (2019) Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-17.
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Yiluan Wang, Yuanyuan Shan, Yiyan Wang, Yinghui Fang, Tongliang Huang, Songxue Wang, Qiqi Zhu, Xiaoheng Li & Ren-Shan Ge. (2019) Aconitine inhibits androgen synthesis enzymes by rat immature Leydig cells via down-regulating androgen synthetic enzyme expression in vitro. Chemico-Biological Interactions 312, pages 108817.
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Kwesi Boadu Mensah, Charles Benneh, Arnold Donkor Forkuo & Charles Ansah. (2019) Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos . Biochemistry Research International 2019, pages 1-7.
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