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Drug and Chemical Toxicology Volume 45, 2022 - Issue 1
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Research Article

Metformin ameliorates acetaminophen-induced sub-acute toxicity via antioxidant property

Shambhoo Sharan Tripathia Department of Biochemistry, University of Allahabad, Allahabad, IndiaView further author information
,
Sandeep Singha Department of Biochemistry, University of Allahabad, Allahabad, IndiaView further author information
,
Geetika Garga Department of Biochemistry, University of Allahabad, Allahabad, IndiaView further author information
,
Raushan Kumara Department of Biochemistry, University of Allahabad, Allahabad, IndiaView further author information
,
Avnish Kumar Vermaa Department of Biochemistry, University of Allahabad, Allahabad, IndiaView further author information
,
Abhishek Kumar Singha Department of Biochemistry, University of Allahabad, Allahabad, IndiaView further author information
,
Akalabya Bissoyib Institute of Biochemistry, Food Science and Nutrition, The Hebrew University of Jerusalem, Rehovot, IsraelView further author information
&
Syed Ibrahim Rizvia Department of Biochemistry, University of Allahabad, Allahabad, IndiaCorrespondence[email protected]
View further author information
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Pages 52-60 | Received 04 Jul 2019, Accepted 10 Aug 2019, Published online: 02 Sep 2019

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Muhammad Jamal, Muhammad Azam & Shabana Usman Simjee. (2023) Combination of metformin and sub-therapeutic dose of valproic acid prevent valproic acid-induced toxicity in animal model of epilepsy. Drug and Chemical Toxicology 0:0, pages 1-9.
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Articles from other publishers (19)

Xiaoyuan Wang, Ye Gong, Wenfei Li, Ning Liu, Zishuo Fang, Nihe Zhang, Naisong Chen & Songlin Li. (2024) The beneficial effects of metformin inclusion on growth performance, glucose utilization, antioxidant capacity and apoptosis of largemouth bass (Micropterus salmoides) fed with high dietary carbohydrates. Aquaculture 588, pages 740957.
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Diana Belen Onofre-Camarena, Gustavo Axel Elizalde-Velázquez, Leobardo Manuel Gómez-Oliván, Sandra García-Medina, Marcela Galar-Martínez, José Roberto Jerónimo Juárez & Selene Elizabeth Herrera-Vázquez. (2024) Assessing the impact of COVID-19 era drug combinations on hepatic functionality: A thorough investigation in adult Danio rerio. Environmental Pollution 349, pages 123997.
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Emre Kaya, Seval Yilmaz, Feyza Aksu & Ahmet Kavaklı. (2024) Evaluation of the effects of overdose Acetaminophen toxicity in rats: Ozone, which can be preferred as a complementary therapy. Revista Científica de la Facultad de Ciencias Veterinarias XXXIV:1, pages 1-9.
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Minah Cho, Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee & Hei Sung Kim. (2023) Metformin: A Potential Treatment for Acne, Hidradenitis Suppurativa and Rosacea. Acta Dermato-Venereologica 103, pages adv18392.
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Pervin Işik Bilgili, Saliha Esin Çelik & Reşat Apak. (2023) Gamma-cyclodextrin functionalized silver nanoparticle-based colorimetric assay for the determination of metformin in pharmaceutical samples. Journal of Inclusion Phenomena and Macrocyclic Chemistry.
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Yue Zhu, Zhuo Wang, Chao Gao, Lei Zhang & Rubo Sui. (2023) Oxymatrine-mediated prevention of amyloid β-peptide-induced apoptosis on Alzheimer’s model PC12 cells: in vitro cell culture studies and in vivo cognitive assessment in rats. Inflammopharmacology 31:5, pages 2685-2699.
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Amirhossein Malaekeh-Nikouei, Sina Shokri-Naei, Sobhan Karbasforoushan, Hossein Bahari, Vafa Baradaran Rahimi, Reza Heidari & Vahid Reza Askari. (2023) Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins. Biomedicine & Pharmacotherapy 165, pages 115263.
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Fausat Kikelomo Ola- Mudathir, Ighorhiowhoaro Ajekevwoda, Sikirullai Jeje, Ogheneoruese Onoharigho & Kelechi Adikaesieme. (2023) Nephroprotective Effect of Methanol Extract of Crassocephalum Crepidioides (Benth.) S. Moore (Ebolo) during Paracetamol- Induced toxicity in Wistar Rats. Acta Biologica Slovenica 66:1.
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Kareman M. El-Beheiry, Magda El-Sayed El-Sayad, Thanaa A. El-Masry & Alaa E. Elsisi. (2023) Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway. International Immunopharmacology 117, pages 109891.
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Lea Njeka Wojnarova, Nikolina Kutinova Canova, Mahak Arora & Hassan Farghali. (2023) Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury. Biomedical Papers 167:1, pages 50-60.
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Hesham Taher, Mahmoud S. Sabra, Alaa El-Din Salah El-Din & Alaa El-Din H. Sayed. (2022) Hemato-biochemical indices alteration, oxidative stress, and immune suppression in the African catfish (Clarias gariepinus) exposed to metformin. Toxicology and Environmental Health Sciences 14:4, pages 361-369.
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Raushan Kumar, Jitendra Kumar Arya & Syed Ibrahim Rizvi. (2022) Chitosan reduces inflammation and protects against oxidative stress in a hyperlipidemic rat model: relevance to nonalcoholic fatty liver disease. Molecular Biology Reports 49:10, pages 9465-9472.
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Jie Zhao, Peng-cheng Yang, Hua Yang, Zhi-bo Wang, M.A. El-Samahy, Feng Wang & Yan-li Zhang. (2022) Dietary supplementation with metformin improves testis function and semen quality and increases antioxidants and autophagy capacity in goats. Theriogenology 188, pages 79-89.
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Gabriel Veniamin Cozma, Alexandru Apostu, Ioana Macasoi, Cristina Adriana Dehelean, Octavian Marius Cretu, Stefania Dinu, Dan Gaiță & Aniko Manea. (2022) In Vitro and In Ovo Evaluation of the Potential Hepatoprotective Effect of Metformin. Medicina 58:6, pages 705.
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Maki Mizogami & Hironori Tsuchiya. (2022) Acetaminophen Has Lipid Composition-Dependent Membrane Interactivity That Could Be Related to Nephrotoxicity but Not to Analgesic Activity and Hepatotoxicity. Medical Principles and Practice 31:2, pages 111-117.
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Shambhoo Sharan TripathiRaushan KumarJitendra Kumar AryaSyed Ibrahim Rizvi. (2021) Plasma from Young Rats Injected into Old Rats Induce Antiaging Effects. Rejuvenation Research 24:3, pages 206-212.
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Mustafa Demir, Bulent Yilmaz, Senol Kalyoncu, Meltem Tuncer, Zehra Bozdag, Onur Ince, Mehmet Akif Bozdayi, Hasan Ulusal & Seyithan Taysi. (2021) Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress. Taiwanese Journal of Obstetrics and Gynecology 60:1, pages 45-50.
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Yaxin Sun, Xinying Wang, Yuanyuan Zhou, Junhong Zhang, Weiqi Cui, Enyin Wang, Juan Du, Bo Wei & Xia Xu. (2021) Protective effect of metformin on BPA-induced liver toxicity in rats through upregulation of cystathionine β synthase and cystathionine γ lyase expression. Science of The Total Environment 750, pages 141685.
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Pankaj Tripathi, Saeed Alshahrani, Hassan A. Alhazmi, Rina Tripathi, Abdul Hakeem Siddiqui, Waquar Ahsan & Mohammed Al Bratty. (2020) In vivo assessment of genotoxic potential of brown shammah (smokeless tobacco) in bone marrow cells of mice. Saudi Pharmaceutical Journal 28:4, pages 480-486.
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