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Drug and Chemical Toxicology Volume 45, 2022 - Issue 1
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Research Article

Agomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation

H. Ascia Department of Pharmacology, Faculty of Medicine/Medicine, Medical Device and Dermocosmetic Research and Application Laboratory (IDAL), Suleyman Demirel University, Isparta, TurkeyCorrespondence[email protected]
,
O. Ozmenb Department of Pathology, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, Burdur, TurkeyORCID Iconhttps://orcid.org/0000-0002-1835-1082
ORCID Icon,
Y. Erzurumluc Department of Biochemistry, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Turkey
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A. Sofud Department of Bioengineering, Faculty of Engineering, Suleyman Demirel University, Isparta, Turkey
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P. Ictena Department of Pharmacology, Faculty of Medicine/Medicine, Medical Device and Dermocosmetic Research and Application Laboratory (IDAL), Suleyman Demirel University, Isparta, Turkey
&
M. Kaynaka Department of Pharmacology, Faculty of Medicine/Medicine, Medical Device and Dermocosmetic Research and Application Laboratory (IDAL), Suleyman Demirel University, Isparta, Turkey
Pages 133-142 | Received 15 Apr 2019, Accepted 26 Aug 2019, Published online: 13 Sep 2019

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H. Asci, O. Ozmen, Y. Erzurumlu, H. B. Savas, E. N. Temel, P. Icten & N. Hasseyid. (2021) Ameliorative effects of pregabalin on LPS induced endothelial and cardiac toxicity. Biotechnic & Histochemistry 96:5, pages 364-375.
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Articles from other publishers (12)

Jiaxi Xu, Cheng Zhu, Piaopiao Jin, Wangdi Sun & Enyan Yu. (2024) Agomelatine prevented depression in the chronic restraint stress model through enhanced catalase activity and halted oxidative stress. PLOS ONE 19:2, pages e0289248.
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Reem S. Alruhaimi, Emad H.M. Hassanein, Mostafa K. Abd El-Aziz, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emadeldin M. Kamel & Ayman M. Mahmoud. (2023) The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating Nrf2/HO-1 pathway. International Immunopharmacology 124, pages 110833.
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Reem S. Alruhaimi, Emad H.M. Hassanein, May N. Bin-Jumah & Ayman M. Mahmoud. (2023) Cadmium cardiotoxicity is associated with oxidative stress and upregulated TLR-4/NF-kB pathway in rats; protective role of agomelatine. Food and Chemical Toxicology 180, pages 114055.
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Mahmoud Hosseini, Zohreh Arab, Farimah Beheshti, Akbar Anaeigoudari, Farzaneh Shakeri & Arezoo Rajabian. (2023) Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress . Animal Models and Experimental Medicine 6:3, pages 221-229.
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Nevertyty M. Mahmoud, Shimaa M. Elshazly, Arwa A. Hassan & Eman Soliman. (2023) Agomelatine improves streptozotocin-induced diabetic nephropathy through melatonin receptors/SIRT1 signaling pathway. International Immunopharmacology 115, pages 109646.
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Tian Lan, Yuhan Wu, Yulei Zhang, Shuhan Li, Zhanpeng Zhu, Liyan Wang, Xueqin Mao, Ye Li, Cuiqin Fan, Wenjing Wang & Shu Yan Yu. (2022) Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway. Journal of Neuroinflammation 19:1.
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Heba M. Hafez, Shaimaa Waz, Nashwa Fathy Gamal El-Tahawy & Mervat Z. Mohamed. (2022) Agomelatine ameliorates cadmium-induced toxicity through the modification of HMGB-1/TLR-4/NFκB pathway. Toxicology and Applied Pharmacology 457, pages 116313.
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Belma DAYI & Alper SEVİMLİ. (2022) Approach to Acute Phase Reactions in the Aspects of Pathology and General Situation in TurkeyAkut Faz Reaksiyonlarına Patoloji Açısından Yaklaşım ve Türkiye’deki Genel Durum. Harran Üniversitesi Veteriner Fakültesi Dergisi 11:1, pages 132-138.
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Najiao Hong, Zhirong Ye, Yongjun Lin, Wensen Liu, Na Xu & Yan Wang. (2021) Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion. Aging 13:14, pages 18515-18526.
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Yiqiang Cao, Fei Wang, Yonggang Wang & Jiang Long. (2021) Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model. Aging 13:10, pages 13548-13559.
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Somaieh Ahmadabady, Farimah Beheshti, Fatemeh Shahidpour, Elnaz Khordad & Mahmoud Hosseini. (2021) A protective effect of curcumin on cardiovascular oxidative stress indicators in systemic inflammation induced by lipopolysaccharide in rats. Biochemistry and Biophysics Reports 25, pages 100908.
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Hanaa M. Khalaf, Ahlam M. Abdalla, Amira F. Ahmed & Asmaa Mohamed Abdel-Aziz. (2020) Role of nitric oxide in mediating the cardioprotective effect of agomelatine against isoproterenol-induced myocardial injury in rats. Naunyn-Schmiedeberg's Archives of Pharmacology 393:10, pages 1809-1823.
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