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Drug and Chemical Toxicology Volume 45, 2022 - Issue 3
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Research Articles

Zingerone protects liver and kidney tissues by preventing oxidative stress, inflammation, and apoptosis in methotrexate-treated rats

Erdinç Türka Department of Pharmacology and Toxicology, Mustafa Kemal University, Hatay, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1735-1774View further author information
ORCID Icon,
Mehmet Güvençb Department of Physiology, Mustafa Kemal University, Hatay, TurkeyORCID Iconhttps://orcid.org/0000-0002-9716-0697View further author information
ORCID Icon,
Mustafa Cellatb Department of Physiology, Mustafa Kemal University, Hatay, TurkeyView further author information
,
Ahmet Uyarc Department of Pathology, Mustafa Kemal University, Hatay, TurkeyORCID Iconhttps://orcid.org/0000-0003-4345-6756View further author information
ORCID Icon,
Müslüm Kuzud Department of Nutrition and Dietetics, Karabuk University, Karabuk, TurkeyView further author information
,
Ahmet Gökhan Ağgüle Department of Biochemistry, Agri Ibrahim Cecen University, Agri, TurkeyView further author information
&
Akın Kırbaşf Department of Internal Medicine, Bozok University, Yozgat, TurkeyView further author information
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Pages 1054-1065 | Received 14 May 2020, Accepted 26 Jul 2020, Published online: 11 Aug 2020

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Elif Erdem Guzel, Nalan Kaya Tektemur, Ahmet Tektemur & Ebru Etem Önalan. (2023) Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat. Drug and Chemical Toxicology 46:1, pages 136-143.
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Merve Kahramanoğullari, Mine Erişir, Mine Yaman & Tuba Parlak Ak. (2024) Effects of naringenin on oxidative damage and apoptosis in liver and kidney in rats subjected to chronic mercury chloride. Environmental Toxicology 39:5, pages 2937-2947.
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Eman Abdalhameid, Enas A. Abd El-Haleim, Rania M. Abdelsalam, Gehan S. Georgy, Hala M. Fawzy & Sanaa A. Kenawy. (2023) Cinnamic acid mitigates methotrexate-induced lung fibrosis in rats: comparative study with pirfenidone. Naunyn-Schmiedeberg's Archives of Pharmacology 397:2, pages 1071-1079.
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Mehmet Çömez, Mustafa Cellat, Müslüm Kuzu, Ahmet Uyar, Erdinç Türk, Yusuf Selim Kaya, Muhammed Etyemez, İshak Gökçek & Mehmet Güvenç. (2023) The effect of tyrosol on diclofenac sodium‐induced acute nephrotoxicity in rats. Journal of Biochemical and Molecular Toxicology 38:1.
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Negin Amini, Mahla Hassanzadeh Shoshtari, Fereshteh Nejaddehbashi, Mahin Dianat & Mohammad Badavi. (2023) Dose-dependent renoprotective effect of vanillic acid on methotrexate-induced nephrotoxicity via its anti-apoptosis, antioxidant, and anti-inflammatory properties. Naunyn-Schmiedeberg's Archives of Pharmacology.
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Mustafa Cellat, Müslüm Kuzu, Mehmet Güvenç, Murat Yüksel, Özgür Kanat, Yeşim Akaydın Bozkurt, Muhammed Etyemez & Fikret Karaca. (2023) Safranal's therapeutic effects in rat models of polycystic ovary syndrome. Revista Brasileira de Farmacognosia 34:2, pages 301-312.
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Nurgül Şenol, Melda Şahin & Uğur Şahin. (2023) Protective effect of juglone on electric field-induced apoptosis and inflammation in liver and kidney tissue in rats. Research in Veterinary Science 164, pages 104987.
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Ahmet Uyar, Mustafa Cellat, Özgür Kanat, Muhammed Etyemez, Tuncer Kutlu, Mehmet Yılmaz Zeki Deveci, İlker Yavaş & Müslüm Kuzu. (2023) Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties. Reproductive Toxicology 121, pages 108456.
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Shahnam Shamsabadi, Yazdan Nazer, Javad Ghasemi, Erfan Mahzoon, Vafa Baradaran Rahimi, Basiru O. Ajiboye & Vahid Reza Askari. (2023) Promising influences of zingerone against natural and chemical toxins: A comprehensive and mechanistic review. Toxicon 233, pages 107247.
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Adriana Pérez, Jorge Mukdsi, Laura Valdez, Ivana Rukavina-Mikusic, Gabriela Díaz de Barboza, Nori Tolosa de Talamoni & María Rivoira. (2023) Naringin prevents diabetic nephropathy in rats through blockage of oxidative stress and attenuation of the mitochondrial dysfunction. Canadian Journal of Physiology and Pharmacology 101:7, pages 349-360.
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Abeer A.A. Salama, Noha N. Yassen & Heba M. Mansour. (2023) Naringin protects mice from D-galactose-induced lung aging and mitochondrial dysfunction: Implication of SIRT1 pathways. Life Sciences 324, pages 121471.
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Halil İbrahim BÜYÜKBAYRAM, Dilek BAYRAM & Hatice Kübra DOĞAN. (2023) EVALUATION OF THE PROTECTIVE EFFECT OF RAMELTEON IN METHOTREXATE INDUCED NEPHROTOXICITYMETOTREKSAT ARACILI NEFROTOKSİSİTEDE RAMELTEONUN KORUYUCU ETKİSİNİN DEĞERLENDİRİLMESİ. SDÜ Tıp Fakültesi Dergisi 30:2, pages 155-162.
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Muhamad Syafiq Hakimi Kamaruddin, Gun Hean Chong, Nurizzati Mohd Daud, Nicky Rahmana Putra, Liza Md Salleh & Norhidayah Suleiman. (2023) Bioactivities and green advanced extraction technologies of ginger oleoresin extracts: A review. Food Research International 164, pages 112283.
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Walied Abdo, Imer Haziri, Mohamed Dmerdash, Sulaiman Mohammed Alnasser, Ali Hakamy, Ehab Ali, Soha A. Soliman, Hanan H. Abd-Elhafeez & Ahmed M. Abd-Eldayem. (2022) Anatabine attenuates ovalbumin-induced asthma via oxidative stress and inflammation mitigation and Nrf2/HO-1 signaling upregulation in rats. Life Sciences 308, pages 120954.
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Mosaab Salah El-din El-Agawy, Alaa Mohamed Mohamed Badawy, Mohammed R. Rabei, Mohamed Mahmoud Abdelraheem Elshaer, Eman Mohamad El Nashar, Mansour A. Alghamdi, Mohammed A. Alshehri & Hassan Reda Hassan Elsayed. (2022) Methotrexate-Induced Alteration of Renal Aquaporins 1 and 2, Oxidative Stress and Tubular Apoptosis Can Be Attenuated by Omega-3 Fatty Acids Supplementation. International Journal of Molecular Sciences 23:21, pages 12794.
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Mustafa Cellat, Cafer T. İşler, Tuncer Kutlu, Müslüm Kuzu, Muhammed Etyemez, Halil Alakuş & Mehmet Güvenç. (2022) Investigation of the effects of safranal on the experimentally created rheumatoid arthritis model in rats. Journal of Biochemical and Molecular Toxicology 36:9.
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Zecai Zhang, Yueqi Cui, Siyu Liu, Jiang Huang, Yu Liu, Yulong Zhou & Zhanbo Zhu. (2022) Short‐term treatment with zingerone ameliorates dextran sulfate sodium‐induced mouse experimental colitis. Journal of the Science of Food and Agriculture 102:11, pages 4873-4882.
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Thalat Bokhary, Bassem Refaat, El-Sayed Bakr, Sameh Baz, Bodour Rajab, Hossam Gadalla & Mohamed El-Boshy. (2022) Salvadora persica extract attenuates cyclophosphamide-induced hepatorenal damage by modulating oxidative stress, inflammation and apoptosis in rats. Journal of Integrative Medicine 20:4, pages 348-354.
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Shanshan Tian, Xiaoxia Jiang, Yunping Tang & Tao Han. (2021) Laminaria japonica fucoidan ameliorates cyclophosphamide‐induced liver and kidney injury possibly by regulating Nrf2/ HO ‐1 and TLR4 / NF‐κB signaling pathways . Journal of the Science of Food and Agriculture 102:6, pages 2604-2612.
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Mustafa Cellat, Müslüm Kuzu, Cafer Tayer İşler, Muhammed Etyemez, Nursel Dikmen, Ahmet Uyar, İshak Gökçek, Erdinç Türk & Mehmet Güvenç. (2021) Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation. Naunyn-Schmiedeberg's Archives of Pharmacology 394:10, pages 2061-2075.
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Bayanda Mdoda, Pilani Nkomozepi & Eliton Chivandi. (2022) Zingerone as a Substitute to Zinc Bacitracin: Effects on Oxidative Stress, Systemic Antioxidant Status, Liver Fat Content, Function and Histomorphometry of Cobb500 Broiler Chicken. SSRN Electronic Journal.
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