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Drug and Chemical Toxicology Volume 46, 2023 - Issue 2

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L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling

Neven Hassana Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Cario, EgyptCorrespondence[email protected]

https://orcid.org/0000-0003-1110-4289 View further author information

Maha Rashadb Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Cario, EgyptView further author information

Ebtihal Elleithyc Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Cario, EgyptView further author information

Zainab Sabryc Department of Cytology and Histology, Faculty of Veterinary Medicine, Cairo University, Cario, EgyptView further author information

Ghada Alib Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Cario, EgyptView further author information

Sherif Elmosalamya Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Cario, EgyptView further author information

Pages 357-368 | Received 05 Aug 2021, Accepted 31 Jan 2022, Published online: 17 Feb 2022

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https://doi.org/10.1080/01480545.2022.2039180
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Amany E. Nofal, Hind S. AboShabaan, Walaa A. Fadda, Rafik E. Ereba, Sherin M. Elsharkawy & Heba M. Hathout. (2024) L-carnitine and Ginkgo biloba Supplementation In Vivo Ameliorates HCD-Induced Steatohepatitis and Dyslipidemia by Regulating Hepatic Metabolism. Cells 13:9, pages 732.
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Asmaa R. Hashim, Dina W. Bashir, Eman Rashad, Mona K. Galal, Maha M. Rashad, Heba M. A. Khalil, Nasrallah M. Deraz & El-Gharbawy S. M.. (2024) Neuroprotective Assessment of Betaine against Copper Oxide Nanoparticle-Induced Neurotoxicity in the Brains of Albino Rats: A Histopathological, Neurochemical, and Molecular Investigation. ACS Chemical Neuroscience 15:8, pages 1684-1701.
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Salma Mostafa Mohamed, Mostafa Abbas Shalaby, Riham A. El-Shiekh, Alaa F. Bakr, Maha M. Rashad, Shimaa R. Emam & Hossny A. El-Banna. (2024) Vitis vinifera L. seed standardized extract; a promising therapeutic against metabolic syndrome induced by high-fat/high-carbohydrate diet and streptozotocin in rats. South African Journal of Botany 167, pages 476-486.
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Francesca Scatozza, Maria Miriam Giardina, Carola Valente, Virginia Vigiano Benedetti & Antonio Facchiano. (2024) Anti-Melanoma Effects of Miconazole: Investigating the Mitochondria Involvement. International Journal of Molecular Sciences 25:7, pages 3589.
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Salma Mostafa Mohamed, Mostafa Abbas Shalaby, Riham A. El-Shiekh, Alaa F. Bakr, Shaimaa Kamel, Shimaa R. Emam & Hossny A. El-Banna. (2024) Maca roots: A potential therapeutic in the management of metabolic disorders through the modulation of metabolic biochemical markers in rats fed high-fat high-carbohydrate diet. Journal of Ethnopharmacology 321, pages 117533.
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Salwa Farid Ahmed, Eman M. F. El-Maghraby, Maha M. Rashad & Dina W. Bashir. (2024) Iron overload induced submandibular glands toxicity in gamma irradiated rats with possible mitigation by hesperidin and rutin. BMC Pharmacology and Toxicology 25:1.
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Manar A. Eissa & Eman Y. Gohar. (2023) Aromatase enzyme: Paving the way for exploring aromatization for cardio-renal protection. Biomedicine & Pharmacotherapy 168, pages 115832.
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Ahmed Hesham, Marwa Abass, Haanin Abdou, Reham Fahmy, Maha M. Rashad, Abdelnaser A. Abdallah, Wael Mossallem, Ibrahim F. Rehan, Asmaa Elnagar, František Zigo, Silvia Ondrašovičová, Ahmed F. Abouelnaga & Awad Rizk. (2023) Ozonated saline intradermal injection: promising therapy for accelerated cutaneous wound healing in diabetic rats. Frontiers in Veterinary Science 10.
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Neven H. Hassan, Sally Mehanna, Ahmed M. Hussien, Marwa A. Ibrahim & Eman I. Hassanen. (2023) The potential mechanism underlying the hepatorenal toxicity induced by hymexazol in rats and the role of NF‐κB signaling pathway. Journal of Biochemical and Molecular Toxicology 37:4.
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Sherif H. Elmosalamy, Ebtihal M. M. Elleithy, Zainab Sabry Othman Ahmed, Maha M. Rashad, Ghada E. Ali & Neven H. Hassan. (2022) Dysregulation of intraovarian redox status and steroidogenesis pathway in letrozole-induced PCOS rat model: a possible modulatory role of l-Carnitine. Beni-Suef University Journal of Basic and Applied Sciences 11:1.
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Thirumurugan Ayyadurai, Anil Kumar Moola, Prasobh K. Mohan, Senthil Kumar Thiruppathi, Achiraman Shanmugam & Ranjitha Kumari Bollipo Diana. (2022) Ameliorative effects of Guilandina bonduc L. aqueous seed extract on letrozole induced polycystic ovary syndrome in female wistar albino rats. Advances in Traditional Medicine 22:4, pages 885-903.
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Eman I. Hassanen, Ahmed M. Hussien, Neven H. Hassan, Marwa A. Ibrahim & Sally Mehanna. (2022) A Comprehensive Study on the Mechanistic Way of Hexaflumuron and Hymexazol Induced Neurobehavioral Toxicity in Rats. Neurochemical Research 47:10, pages 3051-3062.
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L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling

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L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, Cyt c and CASP-3 signaling

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