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Drug and Chemical Toxicology Volume 46, 2023 - Issue 3
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Research Articles

Evaluation of the toxicological effects of favipiravir (T-705) on liver and kidney in rats: biochemical and histopathological approach

Adem Karaa Department of Molecular Biology and Genetics, Faculty of Science, Erzurum Technique University, Erzurum, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5766-6116
ORCID Icon,
Seda Yakutb Department of Histology and Embryology, Faculty of Veterinary Medicine, Bingol University, Bingol, TurkeyORCID Iconhttps://orcid.org/0000-0003-1673-5661
ORCID Icon,
Cuneyt Caglayanc Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, Bingol, TurkeyORCID Iconhttps://orcid.org/0000-0001-5608-554X
ORCID Icon,
Tuğçe Atçalıd Department of Physiology, Faculty of Veterinary Medicine, Bingol University, Bingol, TurkeyORCID Iconhttps://orcid.org/0000-0002-9566-7531
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Aykut Ulucane Department of Medical Services and Techniques, Vocational School of Health Services, Bingol University, Bingol, TurkeyORCID Iconhttps://orcid.org/0000-0001-8844-8237
ORCID Icon &
Fatih Mehmet Kandemirf Department of Biochemistry, Faculty of Veterinary Medicine, Atatürk University, Erzurum, TurkeyORCID Iconhttps://orcid.org/0000-0002-8490-2479
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Pages 546-556 | Received 01 Dec 2021, Accepted 10 Mar 2022, Published online: 21 Apr 2022

Citations (8)

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Delil Özcan, Fatih Özçelik, Renad Mammadov, Mehmet Aktaş, Fikret Altındağ, Abdurrahman Alpaslan Alkan, Murat Karapapak, Durdu Altuner & Halis Süleyman. (2024) Biochemical and histopathological evaluation of systemic and ocular toxicity of favipiravir in rats. Cutaneous and Ocular Toxicology 0:0, pages 1-8.
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Muhammed Fatih Doğan, Kürşat Kaya, Hasan Hüseyin Demirel, Mehmet Başeğmez, Yasemin Şahin & Osman Çiftçi. (2023) The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats. Immunopharmacology and Immunotoxicology 45:5, pages 521-526.
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Kürşat Kaya, Yasemin Şahin, Hasan Hüseyin Demirel & Osman Çiftçi. (2023) Investigation of oxidative, inflammatory and apoptotic effects of favipiravir use alone and combined with vitamin C on brain tissue of elderly rats. Drug and Chemical Toxicology 0:0, pages 1-9.
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Pasquale Pagliano, Carmine Sellitto, Tiziana Ascione, Giuliana Scarpati, Veronica Folliero, Ornella Piazza, Gianluigi Franci, Amelia Filippelli & Valeria Conti. (2022) The preclinical discovery and development of molnupiravir for the treatment of SARS-CoV-2 (COVID-19). Expert Opinion on Drug Discovery 17:12, pages 1299-1311.
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Articles from other publishers (4)

Bekir Elma, Bahadir Suleyman, Renad Mammadov, Bulent Yavuzer, Edhem Unver, Durdu Altuner, Taha Coban, Behzad Mokhtare & Halis Suleyman. (2024) Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation.. Investigación Clínica 65:1, pages 83-98.
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Elif Erbaş, Nevra Aydemir Celep, Deniz Tekiner, Aydın Genç & Semin Gedikli. (2023) Assessment of toxicological effects of favipiravir (T‐705) on the lung tissue of rats: An experimental study. Journal of Biochemical and Molecular Toxicology 38:1.
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Shiza Malik, Omar Ahsan, Hassan Mumtaz, Muhammad Tahir Khan, Ranjit Sah & Yasir Waheed. (2023) Tracing down the Updates on Dengue Virus—Molecular Biology, Antivirals, and Vaccine Strategies. Vaccines 11:8, pages 1328.
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Ozlem Akbal-Dagistan, Mustafa Sevim, Leyla Semiha Sen, Nur Sena Basarir, Meltem Culha, Aybige Erturk, Hanan Fael, Engin Kaptan, Serap Sancar, Lutfiye Mulazimoglu Durmusoglu, Berrak C. Yegen & Ayca Yildiz-Pekoz. (2022) Pulmonary Delivery of Favipiravir in Rats Reaches High Local Concentrations without Causing Oxidative Lung Injury or Systemic Side Effects. Pharmaceutics 14:11, pages 2375.
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